A contribution to the study of sex-determination in the anura

The problem of sex -determination possesses a peculiar fascination for the student of. animate Nature and the fact that it remains as yet unsolved, permits one to set out on the great adventure of its solution with high hopes and, if one is young, with confidence.But with the experience of the difficulties and complexities of the subject comes a chastened mind, and at the journey's end one is left with just the hope that in the results of the work which has enslaved by its all -absorbing fascination, there may be found some suggestion as to the direction in which the truth of the matter really lies.In this study the question of sex- determination is approached through a consideration of the abnormalities of the reproductive system which have been recorded in Zoological literature. Often an appreciation of the abnormal can illumine the mechanism of the normal.The typical sexual characters are first briefly described, so as to furnish standards to which the abnormalities may be referred. The abnormalities are then tabulated and analysed. A brief consideration of the embryology of the reproductive system naturally follows and the investigation is brought to a close by a review of what is known of the sex-ratio. An account is given of certain experiments.It is intended to demonstrate that the abnormalities obviously suggest that in the case of the frog, sex is not irreversible; that the facts of embryology lend support to this view; and that a .study of the variations of the sex -ratio supplies conclusive proof that sax- reversal can and does occur. The graduated degrees of abnormality as portrayed, are shown . to provide a clear view of the process by which sex-reversal is effected

Black-Footed Ferret Recovery

The captive population of black-footed ferrets increased from 24 to 58 animals in 1988, and was split to provide the species added protection against extinction. Experimental reintroductions may begin in 1991. In some areas, experimental population designations as authorized under Section 10 (j) of the Endangered Species Act may be used to provide wider management latitude. The Black-footed Ferret Interstate Coordinating Committee oversees much of the work related to reintroduction. Expanded effort to locate wild ferrets now includes a $10,000 reward offer. Research focuses on captive breeding, reintroduction techniques, disease, and habitat. A new Recovery Plan was approved in 1988

Black-Footed Ferret Recovery

The captive population of black-footed ferrets increased from 24 to 58 animals in 1988, and was split to provide the species added protection against extinction. Experimental reintroductions may begin in 1991. In some areas, experimental population designations as authorized under Section 10 (j) of the Endangered Species Act may be used to provide wider management latitude. The Black-footed Ferret Interstate Coordinating Committee oversees much of the work related to reintroduction. Expanded effort to locate wild ferrets now includes a $10,000 reward offer. Research focuses on captive breeding, reintroduction techniques, disease, and habitat. A new Recovery Plan was approved in 1988

Precision Pointing of IBEX-Lo Observations

Post-launch boresight of the IBEX-Lo instrument onboard the Interstellar Boundary Explorer (IBEX) is determined based on IBEX-Lo Star Sensor observations. Accurate information on the boresight of the neutral gas camera is essential for precise determination of interstellar gas flow parameters. Utilizing spin-phase information from the spacecraft attitude control system (ACS), positions of stars observed by the Star Sensor during two years of IBEX measurements were analyzed and compared with positions obtained from a star catalog. No statistically significant differences were observed beyond those expected from the pre-launch uncertainty in the Star Sensor mounting. Based on the star observations and their positions in the spacecraft reference system, pointing of the IBEX satellite spin axis was determined and compared with the pointing obtained from the ACS. Again, no statistically significant deviations were observed. We conclude that no systematic correction for boresight geometry is needed in the analysis of IBEX-Lo observations to determine neutral interstellar gas flow properties. A stack-up of uncertainties in attitude knowledge shows that the instantaneous IBEX-Lo pointing is determined to within \sim 0.1\degr in both spin angle and elevation using either the Star Sensor or the ACS. Further, the Star Sensor can be used to independently determine the spacecraft spin axis. Thus, Star Sensor data can be used reliably to correct the spin phase when the Star Tracker (used by the ACS) is disabled by bright objects in its field-of-view. The Star Sensor can also determine the spin axis during most orbits and thus provides redundancy for the Star Tracker.Comment: 22 pages, 18 figure

230 GHz VLBI OBSERVATIONS OF M87: EVENT‐HORIZON‐SCALE STRUCTURE DURING AN ENHANCED VERY‐HIGH‐ENERGY γ‐RAY STATE IN 2012

We report on 230 GHz (1.3 mm) very long baseline interferometry (VLBI) observations of M87 with the Event Horizon Telescope using antennas on Mauna Kea in Hawaii, Mt. Graham in Arizona, and Cedar Flat in California. For the first time, we have acquired 230 GHz VLBI interferometric phase information on M87 through measurement of the closure phase on the triangle of long baselines. Most of the measured closure phases are consistent with 0° as expected by physically motivated models for 230 GHz structure such as jet models and accretion disk models. The brightness temperature of the event-horizon-scale structure is ~1 X 10[superscript 10] K derived from the compact flux density of ~1 Jy and the angular size of ~40 µas ~ 5.5 R[subscript s], which is broadly consistent with the peak brightness of the radio cores at 1–86 GHz located within ~10[superscript 2] R[subscript s]. Our observations occurred in the middle of an enhancement in very-high-energy (VHE) γ-ray flux, presumably originating in the vicinity of the central black hole. Our measurements, combined with results of multi-wavelength observations, favor a scenario in which the VHE region has an extended size of ~20–60 R[subscript s]

Small, Low-energy, Dispersive Solar Energetic Particle Events Observed by Parker Solar Probe

The Energetic Particle Instrument–Low Energy (EPI-Lo) experiment has detected several weak, low-energy (~30–300 keV nucleon⁻¹) solar energetic particle (SEP) events during its first two closest approaches to the Sun, providing a unique opportunity to explore the sources of low-energy particle acceleration. As part of the Parker Solar Probe (PSP) Integrated Science Investigation of the Sun (IS⊙IS) suite, EPI-Lo was designed to investigate the physics of energetic particles; however, in the special lowest-energy "time-of-flight only" product used in this study, it also responds to solar photons in a subset of approximately sunward-looking apertures lacking special light-attenuating foils. During the first three perihelia, in a frame rotating with the Sun, PSP undergoes retrograde motion, covering a 17° heliographic longitudinal range three times during the course of the ~11-day perihelion passes, permitting a unique spatial and temporal study into the location, correlation, and persistence of previously unmeasurable SEPs. We examine the signatures of these SEPs (during the first PSP perihelion pass only) and the connection to possible solar sources using remote observations from the Solar Dynamics Observatory (SDO), the Solar TErrestrial RElations Observatory (STEREO), and the ground-based Global Oscillation Network Group (GONG). The orientation of the Sun relative to STEREO, SDO, and GONG makes such identifications challenging, but we do have several candidates, including an equatorial coronal hole at a Carrington longitude of ~335°. To analyze observations from EPI-Lo, which is a new type of particle instrument, we examine instrumental effects and provide a preliminary separation of the ion signal from the photon background

Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. This was an open-labelled, nonrandomised dose-escalation phase I study. In all, 12 patients with a history of recurrent superficial bladder cancer were grouped into four dose levels (10–150 mg ml−1 in 60 ml saline). Six catheter instillations at weekly intervals were used. Cystoscopy and biopsy were performed before and 3 months after the start of treatment. Suramin was assayed using high-performance liquid chromatography, vascular endothelial growth factor (VEGF) using ELISA (enzyme-linked immunosorbent assay), and urinary protein profile using surface-enhanced laser desorption ionisation mass spectroscopy (SELDI). Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml−1. Urinary VEGF was affected by Suramin at doses above 50 mg ml−1, corresponding to the estimated threshold of saturation of Suramin binding to urine albumin. SELDI showed a specific disappearance of urinary protein peaks during treatment. Intravesical Suramin shows lack of toxicity and low systemic absorption. The results of this phase I trial support expanded clinical trials of efficacy at a dose of 100 mg ml−1 intravesically

Epeak estimator for Gamma-Ray Bursts Observed by the Swift Burst Alert Telescope

We report a correlation based on a spectral simulation study of the prompt emission spectra of gamma-ray bursts (GRBs) detected by the Swift Burst Alert Telescope (BAT). The correlation is between the Epeak energy, which is the peak energy in the \nu F_\nu spectrum, and the photon index (\Gamma) derived from a simple power-law model. The Epeak - \Gamma relation, assuming the typical smoothly broken power-law spectrum of GRBs, is \log Epeak = 3.258 - 0.829\Gamma (1.3 < \Gamma < 2.3). We take into account not only a range of Epeak energies and fluences, but also distributions for both the low-energy photon index and the high-energy photon index in the smoothly broken power-law model. The distribution of burst durations in the BAT GRB sample is also included in the simulation. Our correlation is consistent with the index observed by BAT and Epeak measured by the BAT, and by other GRB instruments. Since about 85% of GRBs observed by the BAT are acceptably fit with the simple power-law model because of the relatively narrow energy range of the BAT, this relationship can be used to estimate Epeak when it is located within the BAT energy range.Comment: 27 pages, 31 figures, accepted for publication in Ap