Approach to diagnosis of liver fibrosis: serum markers review

Hepatic fibrosis is the final stage of many disorders of the liver. Originally, hepatic fibrosis was considered irreversible, however, hepatic fibrosis is now known to be a dynamic process with a significant potential for resolution. Timely diagnosis of liver fibrosis can prevent development of unwanted complications. The diagnosis and quantitation of fibrosis have traditionally relied on liver biopsy. However, there are a number of drawbacks that limit its use. This article reviews the current methods of assessment of hepatic fibrosis based on the serum marker

Threshold of laser destruction of nonlinear GaSe and GaSe:in crystals when exposed to pulsed radiation at a wavelength of 2.1 microns

The aim of this work is to determine the optical breakdown threshold of a single crystal GaSe and GaSe:In when exposed to nanosecond radiation of the two micron range and determining the influence of the energy parameters of the testing radiation on the breakdown threshold. The Ho3+:YAG laser was used as the laser radiation source in this work. Pumping was carried out by a Thule fiber laser.В ст. ошибочно: E. V. Zhuravle

Neonatal sepsis: outcomes and long-term prognosis

The article presents the results of a comparative retrospective study of premature babies, with and without a neonatal sepsis. We studied the main patterns of morbidity in children in the first month after birth and the dynamics of health status by the age of 12 months. Retinopathy and pathology of the immune system are more common in premature babies with a neonatal sepsis at the age of 12 months, which requires special monitoring by narrow specialistВ статье представлены результаты сравнительного ретроспективного обследования детей, родившихся недоношенными. У половины пациентов в анамнезе был неонатальный сепсис. Группу сравнения составили дети с неотягощённым анамнезом по данной патологии. Были изучены основные закономерности заболеваемости детей в первый месяц после рождения и динамика состояния здоровья на протяжении первого года жизни. У недоношенных детей, имеющих в анамнезе неонатальный сепсис, в возрасте 12 месяцев чаще встречалась ретинопатия и патология иммунной системы, что требует особого наблюдения узкими специалистам

Approach to diagnosis of liver fibrosis: serum markers review

Hepatic fibrosis is the final stage of many disorders of the liver. Originally, hepatic fibrosis was considered irreversible, however, hepatic fibrosis is now known to be a dynamic process with a significant potential for resolution. Timely diagnosis of liver fibrosis can prevent development of unwanted complications. The diagnosis and quantitation of fibrosis have traditionally relied on liver biopsy. However, there are a number of drawbacks that limit its use. This article reviews the current methods of assessment of hepatic fibrosis based on the serum marker

INSULIN-LIKE GROWTH FACTOR-1, CYTOLYSIS AND CHOLESTASIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS COMBINATION WITH TYPE 2 DIABETES MELLITUS

Purpose. The study was designed to assess the relationship between the level of plasma concentration of insulin-like growth factor-1 (IGF-1) and indices of the functional state of the liver in patients with non-alcoholic fatty liver disease (NAFLD) and its combination with diabetes mellitus (DM) 2 types depending on the trophological status.Materials and methods. It were examined 90 patients with non-alcoholic fatty liver disease and its combination with type 2 diabetes mellitus –with normal body weight and obesity, as well as 20 healthy individuals. The study was carried out using the following methods: clinical, laboratory and instrumental (including liver biopsy).Results. It was inverse the relationship between the level of IGF-1, and the level of AST, ALT, AST/ALT, total and conjugated bilirubin, alkaline phosphatase in groups of patients with comorbid disorder. There was established the significant decrease of plasma level of IGF-1, and also impairment of liver function indices in all groups in comparison with the controls, and most pronounced changes in patients with comorbid disorders and obesity.Conclusion. The established relationships suggests that the decrease of IGF-1 may represent the presence of syndromes of cytolysis and cholestasis in patients with NAFLD, type 2 DM and obesity. In order to determination the disorder of the reparative function of the liver isrecommended to determine the level of IGF-1 in patients with combination of NAFLD and type 2 DM. Patients with the level of IGF-1 &lt; 143,9 ± 4,92 ng/ml should refer to the risk of progression of liver function disorders.</p

Oxygen Evolution Within Barrier Oxide Films

NRC publication: Ye