Beyond Cell Penetrating Peptides: Designed Molecular Transporters

Inspired originally by peptides that traverse biological barriers, research on molecular transporters has since identified the key structural requirements that govern cellular entry, leading to new, significantly more effective and more readily available agents. These new drug delivery systems enable or enhance cellular and tissue uptake, can be targeted and provide numerous additional advantages of significance in imaging, diagnostics and therapy

Quality of Life in Menopausal Women: A Brazilian Portuguese Version of the Cervantes Scale

We present the translation, cultural adaptation and validation of the Cervantes Scale to Brazilian Portuguese. The Cervantes Scale (CS) was originally described in Spanish, and is a tool to measure health-related quality of life in perimenopausal and menopausal women. A cross-sectional study was carried out with 180 women aged 45 to 64 years. In addition to the CS, the following questionnaires were applied: Women's Health Questionnaire (WHQ) and abbreviated version of the World Health Organization's Quality of Life Questionnaire (Abbreviated WHOQOL-bref). In conclusion, the Brazilian Portuguese version of the CS is easy to apply and understand. The evaluation of its psychometric properties was satisfactory, and it can be applied to assess health-related QoL in Brazilian perimenopausal and menopausal women

Atividade física e terceira idade : um estudo de caso sobre as atividades oferecidas pelo Grupo Viver Feliz, do município de Águas Lindas de Goiás

Monografia (graduação)—Universidade de Brasília, Faculdade de Educação Física, Curso de Licenciatura em Educação Física do Programa Pro–Licenciatura, 2012. Curso de Licenciatura em Educação Física a Distância.Alcançar a 3ª idade atualmente tem sido um privilégio de muita gente, chegar à velhice com saúde é importante para todas as pessoas, porém com o passar dos anos o ser humano passa por diversas transformações até chegar à 3ª idade. O presente trabalho monográfico tem como objetivo identificar os benefícios para a saúde, oferecidos pela atividade física às pessoas da 3ª idade, em especial as atividades oferecidas pelo Grupo Viver Feliz aos seus participantes, do município de Águas Lindas de Goiás. Nesse estudo, além de usar suporte bibliográfico o presente trabalho aborda a realidade de um grupo de idosos, onde foi realizada uma pesquisa através de questionários direcionados aos próprios idosos com intuito de obter informações relacionadas à sua saúde, uso de medicamentos e benefícios observados com a prática das atividades físicas. A metodologia usada para a realização desta pesquisa é o estudo de caso aliado à pesquisa bibliográfica. Após a análise de diversas obras e a observação das atividades do grupo Viver Feliz, foi elaborado um questionário para a entrevista aos participantes do grupo. A análise dos resultados foi realizada com base nas obras lidas e nos resultados obtidos com os questionários aplicados. A atividade física é um meio, considerado por vários autores, de evitar diversas enfermidades. ______________________________________________________________________________ ABSTRACTThe elderly currently have been a privilege of many people reach old age with health is important for all people, but over the years the human being goes through several changes until you reach the 3rd age. This monographic work aims to identify the health benefits offered by physical activity for people of the third age, in particular the activities offered by the group to live happily, their participants, in the city of Águas Lindas de Goiás. In this study, in addition to using bibliographic support the present work deals with the reality of a group of seniors, where he held a survey through questionnaires directed to the elderly themselves in order to obtain information relating to your health, use of medicines and benefits observed with the practice of physical activities. The methodology used to conduct this survey is the coupled to bibliographical research. After the analysis of various works and the observation of the activities of the Group live happily, a questionnaire was prepared for the interview group participants. The analysis of the results was carried out on the basis of works read and results obtained with questionnaires. Physical activity is a means, considered by several authors, to prevent various diseases

Obesity and Cancer Screening according to Race and Gender

The relationship between obesity and cancer screening varies by screening test, race, and gender. Most studies on cervical cancer screening found a negative association between increasing weight and screening, and this negative association was most consistent in white women. Recent literature on mammography reports no association with weight. However, some studies show a negative association in white, but not black, women. In contrast, obese/overweight men reported higher rates of prostate-specific antigen (PSA) testing. Comparison of prostate cancer screening, mammography, and Pap smears implies a gender difference in the relationship between screening behavior and weight. In colorectal cancer (CRC) screening, the relationship between weight and screening in men is inconsistent, while there is a trend towards lower CRC screening in higher weight women

Race/Ethnicity, Gender, Weight Status, and Colorectal Cancer Screening

Background. The literature on colorectal cancer (CRC) screening is contradictory regarding the impact of weight status on CRC screening. This study was intended to determine if CRC screening rates among 2005 National Health Interview Survey (NHIS) respondent racial/ethnic and gender subgroups were influenced by weight status. Methods. Univariable and multivariable logistic regression analyses were performed to determine if CRC screening use differed significantly among obese, overweight, and normal-weight individuals in race/ethnic and gender subgroups. Results. Multivariable analyses showed that CRC screening rates did not differ significantly for individuals within these subgroups who were obese or overweight as compared to their normal-weight peers. Conclusion. Weight status does not contribute to disparities in CRC screening in race/ethnicity and gender subgroups

Impact of postmenopausal vaginal discomfort on sex and relationships in Brazil: the CLOSER survey.

The CLOSER (CLarifying Vaginal Atrophy's Impact On SEx and Relationships) survey investigated how postmenopausal vaginal atrophy (VA) affects relationships between Brazilian women and male partners.Postmenopausal women (age 55-65 years) with VA, and male partners of women with the condition, completed an online survey on the impact of VA and local estrogen treatment on intimacy and relationships.A total of 360 women and 352 men from Brazil were included. Women (83%) and men (91%) reported that they were comfortable discussing VA with their partners. Women's key source of information on VA was health-care providers (HCPs), but 44% felt that not enough information is available. VA caused 70% of women to avoid sexual intimacy and resulted in less satisfying sex. VA had a negative impact on women's feelings and self-esteem. Women (76%) and men (70%) both reported that treatment with vaginal estrogen improved their sexual relationship, primarily by alleviating women's pain during sex. Women (56%) and men (59%) felt closer to each other after treatment.VA had a negative impact on sexual relationships for both women and men in Brazil, and reduced women's self-confidence. Vaginal hormone therapy improved couples' sexual relationships. A proactive attitude of HCPs is essential to educate women on VA and the potential benefits of treatment

The double [3+2] photocycloaddition reaction

One of a synthetic organic chemists‟ greatest challenges is to create step-efficient routes toward compounds with high molecular complexity. Therefore, reactions such as the meta photocycloaddition of an olefin to a benzene derivative, which provide more than one bond in a single step are of significant importance. It this remarkable reaction three new σ bonds, three new rings and up to six new stereocenters are formed simultaneously. Additional complexity can be added by tethering the two reacting partners together and this form of the reaction has found many uses in natural product synthesis. In this work a remarkable double [3+2] photocycloaddition reaction is reported that results in the formation of a complex cis, cis, cis, trans-[5, 5, 5, 5] fenestrane derivative from a simple flat aromatic acetal with two branching alkenes. During this dramatic transformation four carboncarbon bonds, five new rings and seven new stereocenters are created in a single one-pot process using only UV light. The reaction occurs in a sequential manner from the linear meta photocycloadduct, via a secondary [3+2] addition of the alkene across the cyclopropane of the adduct. In addition, an angular meta photocycloadduct also produced in the initial addition step, undergoes an alternative fragmentation-translocation photoreaction to afford a silphinene-like angular tricyclic compound. In this work the investigation of this newly discovered process is discussed via the synthesis and subsequent irradiation of a series of photosubstrates containing different functional groups in the arene-alkene tether. In addition, attempts toward the synthesis of alternative structures using the same double [3+2] photocycloaddition are reported

Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Glycemic management in type 2 diabetes mellitus has become increasingly complex and, to some extent, controversial, with a widening array of pharmacological agents now available (1–5), mounting concerns about their potential adverse effects and new uncertainties regarding the benefits of intensive glycemic control on macrovascular complications (6–9). Many clinicians are therefore perplexed as to the optimal strategies for their patients. As a consequence, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a joint task force to examine the evidence and develop recommendations for antihyperglycemic therapy in nonpregnant adults with type 2 diabetes. Several guideline documents have been developed by members of these two organizations (10) and by other societies and federations (2,11–15). However, an update was deemed necessary because of contemporary information on the benefits/risks of glycemic control, recent evidence concerning efficacy and safety of several new drug classes (16,17), the withdrawal/restriction of others, and increasing calls for a move toward more patient-centered care (18,19). This statement has been written incorporating the best available evidence and, where solid support does not exist, using the experience and insight of the writing group, incorporating an extensive review by additional experts (acknowledged below). The document refers to glycemic control; yet this clearly needs to be pursued within a multifactorial risk reduction framework. This stems from the fact that patients with type 2 diabetes are at increased risk of cardiovascular morbidity and mortality; the aggressive management of cardiovascular