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Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
Preserving cognition and mental capacity is critical to aging with autonomy. Early detection of pathological cognitive decline facilitates the greatest impact of restorative or preventative treatments. Artificial Intelligence (AI) in healthcare is the use of computational algorithms that mimic human cognitive functions to analyze complex medical data. AI technologies like machine learning (ML) support the integration of biological, psychological, and social factors when approaching diagnosis, prognosis, and treatment of disease. This paper serves to acquaint clinicians and other stakeholders with the use, benefits, and limitations of AI for predicting, diagnosing, and classifying mild and major neurocognitive impairments, by providing a conceptual overview of this topic with emphasis on the features explored and AI techniques employed. We present studies that fell into six categories of features used for these purposes: (1) sociodemographics; (2) clinical and psychometric assessments; (3) neuroimaging and neurophysiology; (4) electronic health records and claims; (5) novel assessments (e.g., sensors for digital data); and (6) genomics/other omics. For each category we provide examples of AI approaches, including supervised and unsupervised ML, deep learning, and natural language processing. AI technology, still nascent in healthcare, has great potential to transform the way we diagnose and treat patients with neurocognitive disorders
Phase-Space Decoherence: a comparison between Consistent Histories and Environment Induced Superselection
We examine the decoherence properties of a quantum open system as modeled by
a quantum optical system in the Markov regime. We look for decoherence in both
the Environment Induced Superselection (EIS) and Consistent Histories (CH)
frameworks. We propose a general measure of the coherence of the reduced
density matrix and find that EIS decoherence occurs in a number of bases for
this model. The degree of ``diagonality'' achieved increases with bath
temperature. We evaluate the Decoherence Functional of Consistent Histories for
coarse grained phase space two-time projected histories. Using the measures
proposed by Dowker and Halliwell we find that the consistency of the histories
improves with increasing bath temperature, time and final grain size and
decreases with initial grain size. The peaking increases with increasing grain
size and decreases with increasing bath temperature. Adopting the above
proposed measure of ``coherence'' to the Decoherence Functional gives similar
results. The results agree in general with expectations while the anomalous
dependence of the consistency on the initial grain size is discussed.Comment: 27 pages, 5 postscript figs in uuencoded compressed tar format
Replaced: definition of special character for the complex number
The Utility of the Timed Up-and-Go Test in Predicting Cognitive Performance: A Cross-Sectional Study of Independent Living Adults in a Retirement Community.
Physical, emotional, and cognitive changes are well documented in aging populations. We administered a comprehensive battery of mental and physical health measures and the Montreal Cognitive Assessment (MoCA; a cognitive screening tool) to 93 independently living older adults (OAs) residing in a Continuing Care Senior Housing Community. Performance on the Timed Up-and-Go (TUG) test (a measure of functional mobility) correlated more strongly with the MoCA total score than did measures of aging, psychiatric symptoms, sleep, and both self-report and objective physical health. Furthermore, it was associated with MoCA Attention, Language, Memory, and Visuospatial/Executive subscales. The MoCA-TUG relationship remained significant after controlling for demographic and physical/mental health measures. Given that the TUG explained significantly more variance in broad cognitive performance than a comprehensive battery of additional physical and mental health tests, it may function as a multimodal measure of health in OAs, capturing physical changes and correlating with cognitive measures
Superradiance and Phase Multistability in Circuit Quantum Electrodynamics
By modeling the coupling of multiple superconducting qubits to a single
cavity in the circuit-quantum electrodynamics (QED) framework we find that it
should be possible to observe superradiance and phase multistability using
currently available technology. Due to the exceptionally large couplings
present in circuit-QED we predict that superradiant microwave pulses should be
observable with only a very small number of qubits (just three or four), in the
presence of energy relaxation and non-uniform qubit-field coupling strengths.
This paves the way for circuit-QED implementations of superradiant state
readout and decoherence free subspace state encoding in subradiant states. The
system considered here also exhibits phase multistability when driven with
large field amplitudes, and this effect may have applications for collective
qubit readout and for quantum feedback protocols.Comment: Published Versio
Primordial fluctuations from nonlinear couplings
We study the spectrum of primordial fluctuations in theories where the
inflaton field is coupled to massless fields and/or to itself. Conformally
invariant theories generically predict a scale invariant spectrum. Scales
entering the theory through infrared divergences cause logarithmic corrections
to the spectrum, tiltilng it towards the blue. We discuss in some detail
whether these fluctuations are quantum or classical in nature.Comment: 12 pages, Revtex, we added an appendix clarifying our assumptions
about the initial conditions at the beggining of inflatio
Combined cognitive and vocational interventions after mild to moderate traumatic brain injury: study protocol for a randomized controlled trial
Background A considerable proportion of patients with mild to moderate traumatic brain injury (TBI) experience long-lasting somatic, cognitive, and emotional symptoms that may hamper their capacity to return to work (RTW). Although several studies have described medical, psychological, and work-related factors that predict RTW after TBI, well-controlled intervention studies regarding RTW are scarce. Furthermore, there has traditionally been weak collaboration among health-related rehabilitation services, the labor and welfare sector, and workplaces. Methods/design This study protocol describes an innovative randomized controlled trial in which we will explore the effect of combining manualized cognitive rehabilitation (Compensatory Cognitive Training [CCT]) and supported employment (SE) on RTW and related outcomes for patients with mild to moderate TBI in real-life competitive work settings. The study will be carried out in the southeastern region of Norway and thereby be performed within the Norwegian welfare system. Patients aged 18â60 years with mild to moderate TBI who are employed in a minimum 50% position at the time of injury and sick-listed 50% or more for postconcussive symptoms 2 months postinjury will be included in the study. A comprehensive assessment of neurocognitive function, self-reported symptoms, emotional distress, coping style, and quality of life will be performed at baseline, immediately after CCT (3 months after inclusion), following the end of SE (6 months after inclusion), and 12 months following study inclusion. The primary outcome measures are the proportion of participants who have returned to work at 12-month follow-up and length of time until RTW, in addition to work stability as well as work productivity over the first year following the intervention. Secondary outcomes include changes in self-reported symptoms, emotional and cognitive function, and quality of life. Additionally, a qualitative RTW process evaluation focused on organizational challenges at the workplace will be performed. Discussion The proposed study will combine cognitive and vocational rehabilitation and explore the efficacy of increased cross-sectoral collaboration between specialized health care services and the labor and welfare system. If the intervention proves effective, the project will describe the cost-effectiveness and utility of the program and thereby provide important information for policy makers. In addition, knowledge about the RTW process for persons with TBI and their workplaces will be provided. Trial registration ClinicalTrials.gov, NCT03092713. Registered on 10 March 2017
Geometric observation for the Bures fidelity between two states of a qubit
In this Brief Report, we present a geometric observation for the Bures
fidelity between two states of a qubit.Comment: 4 pages, 1 figure, RevTex, Accepted by Phys. Rev.
Noise and Fluctuations in Semiclassical Gravity
We continue our earlier investigation of the backreaction problem in
semiclassical gravity with the Schwinger-Keldysh or closed-time-path (CTP)
functional formalism using the language of the decoherent history formulation
of quantum mechanics. Making use of its intimate relation with the
Feynman-Vernon influence functional (IF) method, we examine the statistical
mechanical meaning and show the interrelation of the many quantum processes
involved in the backreaction problem, such as particle creation, decoherence
and dissipation. We show how noise and fluctuation arise naturally from the CTP
formalism. We derive an expression for the CTP effective action in terms of the
Bogolubov coefficients and show how noise is related to the fluctuations in the
number of particles created. In so doing we have extended the old framework of
semiclassical gravity, based on the mean field theory of Einstein equation with
a source given by the expectation value of the energy-momentum tensor, to that
based on a Langevin-type equation, where the dynamics of fluctuations of
spacetime is driven by the quantum fluctuations of the matter field. This
generalized framework is useful for the investigation of quantum processes in
the early universe involving fluctuations, vacuum stability and phase transtion
phenomena and the non-equilibrium thermodynamics of black holes. It is also
essential to an understanding of the transition from any quantum theory of
gravity to classical general relativity. \pacs{pacs numbers:
04.60.+n,98.80.Cq,05.40.+j,03.65.Sq}Comment: Latex 37 pages, umdpp 93-216 (submitted to Phys. Rev. D, 24 Nov.
1993
Stochastic Theory of Relativistic Particles Moving in a Quantum Field: II. Scalar Abraham-Lorentz-Dirac-Langevin Equation, Radiation Reaction and Vacuum Fluctuations
We apply the open systems concept and the influence functional formalism
introduced in Paper I to establish a stochastic theory of relativistic moving
spinless particles in a quantum scalar field. The stochastic regime resting
between the quantum and semi-classical captures the statistical mechanical
attributes of the full theory. Applying the particle-centric world-line
quantization formulation to the quantum field theory of scalar QED we derive a
time-dependent (scalar) Abraham-Lorentz-Dirac (ALD) equation and show that it
is the correct semiclassical limit for nonlinear particle-field systems without
the need of making the dipole or non-relativistic approximations. Progressing
to the stochastic regime, we derive multiparticle ALD-Langevin equations for
nonlinearly coupled particle-field systems. With these equations we show how to
address time-dependent dissipation/noise/renormalization in the semiclassical
and stochastic limits of QED. We clarify the the relation of radiation
reaction, quantum dissipation and vacuum fluctuations and the role that initial
conditions may play in producing non-Lorentz invariant noise. We emphasize the
fundamental role of decoherence in reaching the semiclassical limit, which also
suggests the correct way to think about the issues of runaway solutions and
preacceleration from the presence of third derivative terms in the ALD
equation. We show that the semiclassical self-consistent solutions obtained in
this way are ``paradox'' and pathology free both technically and conceptually.
This self-consistent treatment serves as a new platform for investigations into
problems related to relativistic moving charges.Comment: RevTex; 20 pages, 3 figures, Replaced version has corrected typos,
slightly modified derivation, improved discussion including new section with
comparisons to related work, and expanded reference
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