1,876 research outputs found

    THIACALIX[4]ARENES DERIVATIVES: FROM SELF-ASSEMBY TO FUNCTIONAL MATERIALS

    Full text link
    This work was supported by the by Russian Science Foundation, project # 19-13-00095

    Π₯арактСристика биохимичСского состава ΠΈ антиоксидантной активности Spinacia oleracea L. ΠΈ Spinacia turkestanica Iljin.: ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ исслСдованиС

    Get PDF
    Spinach is an economically important vegetable crop widely cultivated and consumed worldwide. This early ripening leafy vegetable is rich in bioactive components, fiber, micro and macro elements, vitamins, and has high antioxidant activity. Results of numerous studies on the effects of spinach on human health confirm its beneficial effect. The species S. oleracea L. is cultivated commercially. The ancestor of cultivated spinach is S. turkestanica Iljin, which has a breeding potential for different economically valuable traits. Its biochemical composition has been studied extremely little. The present article offers a comparative evaluation of the biochemical profile and antioxidant activity of cultivated and wild spinach species. The material for the study was a representative sample of 48 collection accessions of spinach from the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR). The accessions were grown in 2019 and 2020 in the open ground of the Pushkin and Pavlovsk Laboratories of VIR. The antioxidant activity was studied spectrophotometrically by the DPPH assay of free radical scavenging at a wavelength of 515 nm. A significant similarity of the two species in most biochemical parameters was revealed, which confirms their phylogenetic relationship. Significant differences were found in the content of phenolic elements, which determine the elevated values of antioxidant and antiradical activity of S. turkestanica. The article presents correlation matrices of species biochemical composition, describes general trends, negative relationships and conjugated factors. The identified promising accessions of both cultivated and wild spinach are recommended for breeding for increased content of phenolic compounds, ascorbic acid and antioxidant activity. The result of the study helps to reveal the potential of the crop as a valuable source of bioactive components and high antioxidant activity.Π¨ΠΏΠΈΠ½Π°Ρ‚ - экономичСски значимая овощная ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π°, ΡˆΠΈΡ€ΠΎΠΊΠΎ воздСлываСмая ΠΈ потрСбляСмая Π²ΠΎ всСм ΠΌΠΈΡ€Π΅. Π­Ρ‚ΠΎΡ‚ скороспСлый листовой ΠΎΠ²ΠΎΡ‰ Π±ΠΎΠ³Π°Ρ‚ биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π°ΠΌΠΈ, ΠΊΠ»Π΅Ρ‚Ρ‡Π°Ρ‚ΠΊΠΎΠΉ, ΠΌΠΈΠΊΡ€ΠΎ- ΠΈ макроэлСмСнтами, Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π°ΠΌΠΈ, ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ высокой антиоксидантной Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ. ΠœΠ½ΠΎΠ³ΠΎΡ‡ΠΈΡΠ»Π΅Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ изучСния влияния ΡˆΠΏΠΈΠ½Π°Ρ‚Π° Π½Π° Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°ΡŽΡ‚ Π΅Π³ΠΎ Π±Π»Π°Π³ΠΎΡ‚Π²ΠΎΡ€Π½ΠΎΠ΅ дСйствиС. Π’ производствС ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΡƒΡŽΡ‚ Π²ΠΈΠ΄ S. oleracea L. ΠŸΡ€Π°Ρ€ΠΎΠ΄ΠΈΡ‚Π΅Π»Π΅ΠΌ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° ΡˆΠΏΠΈΠ½Π°Ρ‚Π° являСтся Π²ΠΈΠ΄ S. turkestanica Iljin., ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΠΉ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΠΎΠΌ для сСлСкции ΠΏΠΎ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌ хозяйствСнно-Ρ†Π΅Π½Π½Ρ‹ΠΌ ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠ°ΠΌ. Π•Π³ΠΎ биохимичСский состав ΠΈΠ·ΡƒΡ‡Π΅Π½ ΠΊΡ€Π°ΠΉΠ½Π΅ ΠΌΠ°Π»ΠΎ. Π’ настоящСй Ρ€Π°Π±ΠΎΡ‚Π΅ Π΄Π°Π½Π° ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Π°Ρ ΠΎΡ†Π΅Π½ΠΊΠ° биохимичСского профиля ΠΈ антиоксидантной активности ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½ΠΎΠ³ΠΎ ΠΈ Π΄ΠΈΠΊΠΎΠ³ΠΎ Π²ΠΈΠ΄ΠΎΠ² ΡˆΠΏΠΈΠ½Π°Ρ‚Π°. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠΌ для исслСдования послуТила рСпрСзСнтативная Π²Ρ‹Π±ΠΎΡ€ΠΊΠ° ΠΈΠ· 48 ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ² ΠΊΠΎΠ»Π»Π΅ΠΊΡ†ΠΈΠΈ ΡˆΠΏΠΈΠ½Π°Ρ‚Π° Π’Π˜Π . ΠžΠ±Ρ€Π°Π·Ρ†Ρ‹ Π²Ρ‹Ρ€Π°Ρ‰ΠΈΠ²Π°Π»ΠΈΡΡŒ Π² 2019 ΠΈ 2020 Π³ΠΎΠ΄Ρƒ Π² условиях ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚ΠΎΠ³ΠΎ Π³Ρ€ΡƒΠ½Ρ‚Π° ΠŸΡƒΡˆΠΊΠΈΠ½ΡΠΊΠΈΡ… ΠΈ ΠŸΠ°Π²Π»ΠΎΠ²ΡΠΊΠΈΡ… Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€ΠΈΠΉ ВсСроссийского института гСнСтичСских рСсурсов растСний ΠΈΠΌΠ΅Π½ΠΈ Н.И. Π’Π°Π²ΠΈΠ»ΠΎΠ²Π°. ΠΠ½Ρ‚ΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ‚Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈΠ·ΡƒΡ‡Π°Π»ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ DPPH Π½Π° спСктрофотомСтрС ΠΏΡƒΡ‚Π΅ΠΌ поглощСния свободных Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΠΎΠ² раствора, измСряСмоС ΠΏΡ€ΠΈ Π΄Π»ΠΈΠ½Π΅ Π²ΠΎΠ»Π½Ρ‹ 515 Π½ΠΌ. ВыявлСно Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ сходство Π΄Π²ΡƒΡ… Π²ΠΈΠ΄ΠΎΠ² ΠΏΠΎ Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Ρƒ биохимичСских ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°Π΅Ρ‚ ΠΈΡ… филогСнСтичСскоС родство. БущСствСнныС различия ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Ρ‹ Π² содСрТании Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… элСмСнтов, ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‰ΠΈΡ… ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½Ρ‹Π΅ значСния антиоксидантной ΠΈ Π°Π½Ρ‚ΠΈΡ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ активности S. turkestanica Iljin. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ коррСляционныС ΠΌΠ°Ρ‚Ρ€ΠΈΡ†Ρ‹ Π²ΠΈΠ΄ΠΎΠ²ΠΎΠ³ΠΎ биохимичСского состава, описаны ΠΎΠ±Ρ‰ΠΈΠ΅ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΠΈ, ΠΎΡ‚Ρ€ΠΈΡ†Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ взаимосвязи ΠΈ сопряТСнныС Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹. Π’Ρ‹Π΄Π΅Π»ΠΈΠ²ΡˆΠΈΠ΅ΡΡ пСрспСктивныС ΠΎΠ±Ρ€Π°Π·Ρ†Ρ‹ ΠΊΠ°ΠΊ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½ΠΎΠ³ΠΎ, Ρ‚Π°ΠΊ ΠΈ Π΄ΠΈΠΊΠΎΠ³ΠΎ Π²ΠΈΠ΄ΠΎΠ² ΡˆΠΏΠΈΠ½Π°Ρ‚Π° Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½Ρ‹ для сСлСкции Π½Π° ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ содСрТания Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… соСдинСний, аскорбиновой кислоты ΠΈ антиоксидантной активности. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ исслСдования ΠΏΠΎΠΌΠΎΠ³Π°Π΅Ρ‚ Ρ€Π°ΡΠΊΡ€Ρ‹Ρ‚ΡŒ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Ρ‹, ΠΊΠ°ΠΊ Ρ†Π΅Π½Π½ΠΎΠ³ΠΎ источника биологичСски-Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠ² ΠΈ высокой антиоксидантной активности

    Near-seismic effects in ULF fields and seismo-acoustic emission: statistics and explanation

    No full text
    International audiencePreseismic intensification of fracturing has been investigated from occurrence analysis of seismo-acoustic pulses (SA foreshocks) and ULF magnetic pulses (ULF foreshocks) observed in Karimshino station in addition to seismic foreshocks. Such analysis is produced for about 40 rather strong and nearby isolated earthquakes during 2 years of recording. It is found that occurrence rate of SA foreshocks increases in the interval (-12, 0 h) before main shock with 3-times exceeding of background level in the interval (-6, -3 h), and occurrence probability of SA foreshocks (pA~75%) is higher than probability of seismic foreshocks (ps~30%) in the same time interval.ULF foreshocks are masked by regular ULF activity at local morning and daytime, nevertheless we have discovered an essential ULF intensity increase in the interval (-3, +1 h) at the frequency range 0.05-0.3 Hz. Estimated occurrence probability of ULF foreshocks is about 40%. After theoretical consideration we conclude: 1) Taking into account the number rate of SA foreshocks, their amplitude and frequency range, they emit due to opening of fractures with size of L=70-200 m (M=1-2); 2) The electro-kinetic effect is the most promising mechanism of ULF foreshocks, but it is efficient only if two special conditions are fulfilled: a) origin of fractures near fluid-saturated places or liquid reservoirs (aquifers); b) appearance of open porosity or initiation of percolation instability; 3) Both SA and ULF magnetic field pulses are related to near-distant fractures (r<20-30 km); 4) Taking into account number rate and activation period of seismic, SA and ULF foreshocks, it is rather probable that opening of fractures and rupture of fluid reservoirs occur in the large preparation area with horizontal size about 100-200km

    Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo₆Iβ‚ˆ}⁴⁺ metal clusters

    Get PDF
    Silica nanoparticles (SNPs) doped by hexanuclear molybdenum cluster complexes [{Mo₆Xβ‚ˆ}L₆]n (X = Cl, Br, or I; L = various inorganic or organic ligands) have been recently suggested as materials with a high potential for biomedical applications due to both the outstanding photoluminescent properties and the ability to efficiently generate singlet oxygen upon photoirradiation. However, no studies were undertaken so far to prove this concept. Therefore, here we examined the potential of photoluminescent SNPs doped by {Mo₆Iβ‚ˆ}⁴⁺ for such applications as bioimaging and photodynamic therapy using human epidermoid larynx carcinoma (Hep-2) cell line as a model. Our results demonstrated both: (i) significant luminescence from cells with internalised molybdenum cluster doped SNPs combined with the low cytotoxicity of particles in the darkness and (ii) significant cytotoxicity of the particles upon photoirradiation. Thus, this research provides strong experimental evidence for high potential of molybdenum cluster doped materials in such biomedical applications as optical bioimaging, biolabeling and photodynamic therapy

    Luminescent coordination polymers based on Ca²⁺ and octahedral cluster anions [{M₆Clβ±β‚ˆ}Clᡃ₆}²⁻ (M = Mo, W) : synthesis and thermal stability studies

    Get PDF
    Luminescent coordination polymers (CPs) based of inexpensive stable precursors are attractive materials for applications. Here we report the synthesis and evaluation of the stability and photophysical characteristics of the first examples of phosphorescent CPs based on octahedral molybdenum and tungsten cluster anions. Specifically 1D CP trans-[{Ca(OPPh₃)β‚„}{{M₆Clβ±β‚ˆ}Clᡃ₆}]∞ (M = Mo, W) can be obtained either directly at increased temperature or via intermediate phases [cis-Ca(OPPh₃)β‚„(Hβ‚‚O)β‚‚][{M₆Clβ±β‚ˆ}Clᡃ₆]βˆ™2CH₃CN that are stable at room-temperature, but convert to the titled CP at temperatures above 100 Β°C

    Calixarene-based supramolecular systems: a platform for nanomaterials design by self-assembly

    Full text link
    Lower rim thiacalix[4]arenes derivatives in cone and 1,3-alternate conformations have many advantages to create a wide range of precursors for the design of very sophisticated supramolecular architectures. These compounds can be considered as technological platform for nanomaterials design by self-assembly method. Particular attention will be paid to the application of calixarene derivatives for the construction of various supramolecular and nanosystems, devices and smart materials: colloid nanoparticles, catalytic systems, metalcoordinated networks, Langmuir-Blodgett nanolayers, molecular magnets etc.The authors gratefully acknowledge of the RSF (19-13-00095 and 18-73-10033) for the financial support

    Types of hemodynamic response to orthostasis according to continuous blood pressure monitoring: a case series of heart failure with reduced ejection fraction

    Get PDF
    Heart failure (HF) is associated with unfavorable outcomes and high health care costs. Determination of the hemodynamic response to orthostasis can be an additional tool in assessing the stability and compensation of HF patients. Active orthostatic test (AOT) with blood pressure monitoring serves as a simple and available screening method. However, a complete characteristic of the hemodynamic response, especially during the first minute of orthostasis, can be obtained only with continuous blood pressure monitoring. The presented case series demonstrate the types of hemodynamic response in patients with heart failure with reduced ejection fraction in AOT with continuous blood pressure monitoring, available data on the mechanisms of its development, clinical and prognostic role, and also presents the advantages and limitations of AOT

    Zika virus has an oncolytic activity against human glioblastoma U87 cells

    Get PDF
    Glioblastoma is a highly lethal brain cancer. Virotherapy with the use of oncolytic viruses has since recently been regarded as a promising approach for the clinic treatment of human glioblastomas. The purpose of this work was to perform a primary evaluation of the Zika virus as a potential oncolytic agent against glioblastomas. In vitro experiments showed that the Zika virus strain MR 766 is able to selectively infect and lyse neoplastic cells of the human glioblastoma cell line U87 MG. The selectivity index (SI, the ratio of infectious titer for tumor cells to titer on normal untransformed cells) was 2Β·102. The selectivity of the replicative activity of Zika virus in relation to U87 MG glioblastoma cells was additionally confrmed by indirect immunofluorescence. Using the model of immunodefcient SCID mice with subcutaneous xenografts of human glioblastoma U87 MG, a strong antitumor activity of the Zika virus under a course (daily for 4 days) of intratumoral administration of 5Β·105 TCID50 of Zika virus was shown. Treatment with Zika virus resulted in more than a 10Β­fold reduction in mean volumes of tumors. The tumor growth inhibition index was 92.63 %. Recurrences (metastases) of tumor reΒ­growth were not registered within 64 days of observation. This result demonstrated the prospect of further inΒ­depth studies of the Zika virus as a potential oncolytic agent against human glioblastomas

    Change in body mass index during transition to statutory retirement: an occupational cohort study

    Get PDF
    Background: Retirement is a major life transition affecting health behaviors. The aim of this study was to examine within-individual changes in body mass index (BMI) during transition from full-time work to statutory retirement by sex and physical work characteristics.Methods: A multiwave cohort study repeated every 4 years and data linkage to records from retirement registers. Participants were 5426 Finnish public-sector employees who retired on a statutory basis in 2000-2011 and who reported their body weight one to three times prior to (w(-3), w(-2), w(-1)), and one to three times after (w(+1), w(+2), w(+3)) retirement.Results: During the 4-year retirement transition (w(+1), vs. w(-1)) men showed decline in BMI, which was most marked among men with sedentary work (-0.18 kg/m(2), 95% CI -.30 to -0.05). In contrast, BMI increased during retirement transition in women and was most marked among women with diverse (0.14 kg/m(2), 95% CI 0.08 to 0.20) or physically heavy work (0.31 kg/m(2), 95% CI 0.16 to 0.45). Physical activity during leisure time or commuting to work, alcohol consumption or smoking did not explain the observed changes during retirement transition.Conclusions: In this study statutory retirement was associated with small changes in BMI. Weight loss was most visible in men retiring from sedentary jobs and weight gain in women retiring from diverse and physically heavy jobs
    • …
    corecore