248 research outputs found

    PCN7 Impacto Presupuestario Del Tratamiento En Primera LÍnea Para CÁncer Colorrectal MetastÁsico Basado En XELOX + anti-VEGF o XELOX + anti-EGFR

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    Identification of the water stress level in olive trees during pit hardening using the trunk growth rate indicator.

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    Water scarcity is generating an increasing interest in deficit irrigation scheduling. The trunk diameter fluctuations are daily cycles that have been suggested as tools for irrigation scheduling. The trunk growth rate (TGR) was suggested as the best indicator for olive trees during pit hardening. The aim of this work is to clarify how the TGR could be used to identify water stress levels. The experiment was performed during the 2017 season, in a commercial, super-high-density orchard in Carmona (Seville, Spain). Four different irrigation treatments were performed according to midday stem water potential values and TGR. The data obtained were very variable and both indicators presented a wide range of water status throughout the season. The maximum trunk diameter data clearly showed the pattern of the trees water status but the comparison between treatments and the identification of the water stress level was not possible. The average TGR was linked to the midday stem water potential, but with a minimum amount of data. Irrigation scheduling based on the average TGR was difficult because of the great increases in some daily TGR values. For clarity, the pool of data was grouped by midday stem water potential. These water stress levels were characterized using the weekly frequency of TGR values. The increase of water stress reduced the frequency of values between -0.1 and 0.3mm day-1 from 60% to less than 25%. Moderate water stress levels increased the percentage of values lower than -0.3mm day-1 from 7% to 37%. The most severe water stress conditions increased the TGR values between -0.3 and -0.1mm day-1 from 16% up to 22%.IRNASINSTITUTO DE LA GRASACSI

    Effect of Aspirin on Cell Growth of Human MG-63 Osteosarcoma Line

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    Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in bone tissue repair treatment for their pharmacological action. The objective of this study was to determine the effect of aspirin, on osteoblast growth, using MG63 cell line as osteoblast model. MTT spectrophotometry results showed that 20, 100, and 1000 μM aspirin doses have an inhibitory effect on growth. Cell cycle analysis revealed that aspirin doses of 100 and 1000 μM arrest the cell cycle in phase GO/G1. Parallel apoptosis/necrosis studies showed no changes in comparison to control cells after treatment with 1 or 10 μM aspirin but a significantly increased percentage of cells in apoptosis at doses of 20, 100, and 1000 μM. We highlight that treatment of osteoblast-like cells with 1000 μM aspirin increased not only the percentage of cells in apoptosis but also the percentage of necrotic cells, which was not observed in aspirin treatments at lower doses

    Pre-torsors and Galois comodules over mixed distributive laws

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    We study comodule functors for comonads arising from mixed distributive laws. Their Galois property is reformulated in terms of a (so-called) regular arrow in Street's bicategory of comonads. Between categories possessing equalizers, we introduce the notion of a regular adjunction. An equivalence is proven between the category of pre-torsors over two regular adjunctions (NA,RA)(N_A,R_A) and (NB,RB)(N_B,R_B) on one hand, and the category of regular comonad arrows (RA,ξ)(R_A,\xi) from some equalizer preserving comonad C{\mathbb C} to NBRBN_BR_B on the other. This generalizes a known relationship between pre-torsors over equal commutative rings and Galois objects of coalgebras.Developing a bi-Galois theory of comonads, we show that a pre-torsor over regular adjunctions determines also a second (equalizer preserving) comonad D{\mathbb D} and a co-regular comonad arrow from D{\mathbb D} to NARAN_A R_A, such that the comodule categories of C{\mathbb C} and D{\mathbb D} are equivalent.Comment: 34 pages LaTeX file. v2: a few typos correcte

    The role of impulsivity in dropout from treatment for cigarette smoking

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    AbstractImpulsivity is a variable that has been associated with drug use. This study analyzes impulsivity from two different paradigms, one considering it as a trait and the other based on its behavioral correlates, such as disinhibition and impulsive decision-making in the treatment prognosis (maintain abstinence, relapse and dropout) of smokers after outpatient treatment. The participants in the study were 113 smokers who requested treatment for nicotine addiction. They were assigned to three groups according to whether or not they remained abstinent one month after beginning treatment; thus, group 1 was abstinent, group 2 had relapsed, and group 3 had dropped out of treatment. The participants filled out the Semi-structured Interview for Smokers, the Fargerström Test for Nicotine Dependence, the Temperament and Character Inventory-Revised (TCI-R) and the Delay Discounting Task (DDT). The Delay Discounting variable presents lower scores in the dropout group than in the relapse and abstinent groups, with the highest scores in the relapse group. Differences were also found on the Harm Avoidance (HA) variable, with lower scores in the dropout group compared to the relapse group. The importance of these results lies in the consideration of the smoker’s personality profile in order to prevent both dropout and relapse

    Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation

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    European sea bass were fed four low FM/FO (10%/6%) diets containing galactomannan oligosaccharides (GMOS), a mixture of garlic oil and labiatae plants oils (PHYTO), or a combination of both functional products (GMOSPHYTO) for 63 days before exposing the fish to an intestinal Vibrio anguillarum infection combined with crowding stress. In order to evaluate functional diets efficacy in terms of gut health maintenance, structural, cellular, and immune intestinal status were evaluated by optical and electron microscopy and gene expression analyses. A semi-automated software was adapted to determine variations in goblet cell area and mucosal mucus coverage during the challenge test. Feeding with functional diets did not affect growth performance; however, PHYTO and GMOS dietary inclusion reduced European sea bass susceptibility to V. anguillarum after 7 days of challenge testing. Rectum (post-ileorectal valve) showed longer (p = 0.001) folds than posterior gut (pre-ileorectal valve), whereas posterior gut had thicker submucosa (p = 0.001) and higher mucus coverage as a result of an increased cell density than rectum. Functional diets did not affect mucosal fold length or the grade of granulocytes and lymphocytes infiltration in either intestinal segment. However, the posterior gut fold area covered by goblet cells was smaller in fish fed GMOS (F = 14.53; p = 0.001) and PHYTO (F = 5.52; p = 0.019) than for the other diets. PHYTO (F = 3.95; p = 0.049) reduced posterior gut goblet cell size and increased rodlet cell density (F = 3.604; p = 0.068). Dietary GMOS reduced submucosal thickness (F = 51.31; p = 0.001) and increased rodlet cell density (F = 3.604; p = 0.068) in rectum. Structural TEM analyses revealed a normal intestinal morphological pattern, but the use of GMOS increased rectum microvilli length, whereas the use of PHYTO increased (p 640.10) Ocln, N-Cad and Cad-17 posterior gut gene expression. After bacterial intestinal inoculation, posterior gut of fish fed PHYTO responded in a more controlled and belated way in terms of goblet cell size and mucus coverage in comparison to other treatments. For rectum, the pattern of response was similar for all dietary treatments, however fish fed GMOS maintained goblet cell size along the challenge test

    Assessment of discretely measured indicators and maximum daily trunk shrinkage for detecting water stress in pomegranate trees

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    Measurements obtained by the continuous monitoring of trunk diameter fluctuations were comparedwith discrete measurements of midday stem water potential and midday leaf conductance (gl)in adult pomegranate trees (Punica granatum L. cv. Mollar de Elche). Control plants (T0) were irrigateddaily above their crop water requirements in order to attain non-limiting soil water conditions in 2009 and 2010, while T1 plants were subjected to water stress by depriving them of irrigation water for34 days in 2010, after which time irrigation was restored and plant recovery was studied for 7 days.T1 plants showed a substantial degree of water stress, which developed slowly. Maximum daily trunkshrinkage (MDS) was identified to be the most suitable plant-based indicator for irrigation scheduling inadult pomegranate trees, because its signal:noise ((T1/T0):coefficient of variation) ratio was higher thanthat for midday stem water potential((T1/T0):coefficient of variation) and gl((T0/T1):coefficient of variation). MDS increasedin response to water stress, but when the stemfell below ¿1.67 MPa, the MDS values decreased. Fornon-limiting water conditions, MDS could be predicted from mean daily air temperature (Tm) throughexponential equations fitted to pooled data across several seasons. First-order equations were alsoobtained by pooling data across several seasons to predict MDS from crop reference evapotranspira-tion (ETo), mean daily air vapour pressure deficit (VPDm), Tmand solar radiation (Rs), but these should beused only within a certain range of values (ETo, 2.1¿7.4 mm; VPDm, 0.64¿2.96 kPa; Tm, 12.1¿28.3¿C; Rs,119.4¿331.3 Wm¿2). Hence, automated MDS measurements have the potential to be used in irrigationscheduling of pomegranate, and these values can be normalized to non-limiting water conditions bylocally derived empirical relationships with meteorological variables.Ministerio de Ciencia e Innovación (CICYT/FEDER) AGL2010-19201-C04-01AGRAgencia Española de Cooperación Internacional para el Desarrollo (AECID

    Inorganic, organic, and encapsulated minerals in vegetable meal based diets for Sparus aurata (Linnaeus, 1758)

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    Substituting fishmeal (FM) with vegetable meal (VM) can markedly affect the mineral composition of feeds, and may require additional mineral supplementation. Their bioavailability and optimal supplementation levels depend also on the form of delivery of minerals. The aim of the study was to determine the effect of different delivery forms of three major trace elements (Zn, Mn and Se) in a marine teleost. Gilthead sea bream juveniles of 22.5 g were fed a VM-based diet for 12 weeks that was either not supplemented with these minerals or supplemented with inorganic, organic, or encapsulated inorganic forms of minerals in triplicate and compared to a FM-based diet. Our results showed that mineral delivery form significantly affected the biochemical composition and morphology of posterior vertebrae. Supplementation of VM-based diets with inorganic forms of the target minerals significantly promoted growth, increased the vertebral weight and content of ash and Zn, enhanced bone mineralization and affected the vertebral shape. Conversely, encapsulation of inorganic minerals reduced fish growth and vertebral mineral content, whereas supplementation of organic minerals, enhanced bone osteogenesis by upregulating bone morphogenetic protein 2 (bmp2) gene and produced vertebrae with a larger length in relation to height. Furthermore, organic mineral forms of delivery downregulated the expression of oxidative stress related genes, such as Cu/Zn superoxide dismutase (Cu/Zn sod) and glutathione peroxidase 1 (gpx-1), suggesting thus that dietary minerals supplemented in the organic form could be reasonably considered more effective than the inorganic and encapsulated forms of supply
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