Simulating heat transport of harmonic temperature signals in the Earth's shallow subsurface: Lower-boundary sensitivities

We assess the sensitivity of a subsurface thermodynamic model to the depth of its lower-boundary condition. Analytic solutions to the one-dimensional thermal diffusion equation demonstrate that boundary conditions imposed at shallow depths (2-20 m) corrupt the amplitudes and phases of propagating temperature signals. The presented solutions are for: 1) a homogeneous infinite half-space driven by a harmonic surface-temperature boundary condition, and 2) a homogeneous slab with a harmonic surface-temperature boundary condition and zero-flux lower-boundary condition. Differences between the amplitudes and phases of the two solutions range from 0 to almost 100%, depending on depth, frequency and subsurface thermophysical properties. The implications of our results are straightforward: the corruption of subsurface temperatures can affect model assessments of soil microbial activity, vegetation changes, freeze-thaw cycles, and hydrologic dynamics. It is uncertain, however, whether the reported effects will have large enough impacts on land-atmosphere fluxes of water and energy to affect atmospheric simulations

Characterizing Land–Atmosphere Coupling and the Implications for Subsurface Thermodynamics

The objective of this work is to develop a Simple Land-Interface Model (SLIM) that captures the seasonal and interannual behavior of land–atmosphere coupling, as well as the subsequent subsurface temperature evolution. The model employs the one-dimensional thermal diffusion equation driven by a surface flux boundary condition. While the underlying physics is straightforward, the SLIM framework allows a qualitative understanding of the first-order controls that govern the seasonal coupling between the land and atmosphere by implicitly representing the dominant processes at the land surface. The model is used to perform a suite of experiments that demonstrate how changes in surface air temperature and coupling conditions control subsurface temperature evolution. The work presented here suggests that a collective approach employing both complex and simple models, when joined with analyses of observational data, has the potential to increase understanding of land–atmosphere coupling and the subsequent evolution of subsurface temperatures

Precision cancer monitoring using a novel, fully integrated, microfluidic array partitioning digital PCR platform.

A novel digital PCR (dPCR) platform combining off-the-shelf reagents, a micro-molded plastic microfluidic consumable with a fully integrated single dPCR instrument was developed to address the needs for routine clinical diagnostics. This new platform offers a simplified workflow that enables: rapid time-to-answer; low potential for cross contamination; minimal sample waste; all within a single integrated instrument. Here we showcase the capability of this fully integrated platform to detect and quantify non-small cell lung carcinoma (NSCLC) rare genetic mutants (EGFR T790M) with precision cell-free DNA (cfDNA) standards. Next, we validated the platform with an established chronic myeloid leukemia (CML) fusion gene (BCR-ABL1) assay down to 0.01% mutant allele frequency to highlight the platform's utility for precision cancer monitoring. Thirdly, using a juvenile myelomonocytic leukemia (JMML) patient-specific assay we demonstrate the ability to precisely track an individual cancer patient's response to therapy and show the patient's achievement of complete molecular remission. These three applications highlight the flexibility and utility of this novel fully integrated dPCR platform that has the potential to transform personalized medicine for cancer recurrence monitoring

Impact of Reddit Discussions on Use or Abandonment of Wearables

Discussion platform, Reddit, is the third most visited website in the US. People can post their questions on this platform to get varying opinions from fellow users, which in turn might also influence their behavior and choices. Wearables are becoming widely adopted, yet challenges persist in their effective long term use because of technical and device related, or personal issues. Therefore, by employing sentiment analysis, this paper aims to analyze how decisions of use or abandonment of wearables are influenced by discussions on Reddit. The results are based on the analysis of 6680 posts and their associated 50,867 comments posted between December 2015 - December 2017 on the subreddit (user created groups) on android wear. Our results show that sentiment of the discussion is majorly dictated by the sentiment of the post itself, and people decide to continue using their devices when fellow Redditors offer them workarounds, or the discussion receives majority of positive or fact-driven neutral comments

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING-in-between-RING (RBR)-containing region of HOIP—the catalytic subunit of LUBAC—is sufficient to generate linear ubiquitin chains. However, this activity is inhibited by the N-terminal portion of the molecule, an inhibition that is released upon complex formation with HOIL-1L or SHARPIN. Furthermore, we demonstrate that HOIP transfers ubiquitin to the substrate through a thioester intermediate formed by a conserved cysteine in the RING2 domain, supporting the notion that RBR ligases act as RING/HECT hybrids

Deglacial variability in the surface return flow of the Atlantic meridional overturning circulation

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Paleoceanography 23 (2008): PA1217, doi:10.1029/2007PA001450.Benthic foraminiferal Cd/Ca from a Florida Current sediment core documents the history of the northward penetration of southern source waters within the surface return flow of the Atlantic meridional overturning circulation (AMOC). Cd seawater estimates (CdW) indicate that intermediate-depth southern source waters crossed the equator and contributed to the Florida Current during the Bølling-Allerød warm period of the last deglaciation, consistent with evidence of only a modest AMOC reduction compared to today. The CdW estimates also provide the first paleoceanographic evidence of a reduction in the influence of intermediate-depth southern source waters within the Florida Current during the Younger Dryas, a deglacial cold event characterized by a weak North Atlantic AMOC. Our results reveal a close correspondence between the northward penetration of intermediate-depth southern source waters and the influence of North Atlantic Deep Water, suggesting a possible link between intermediate-depth southern source waters and the strength of the Atlantic AMOC.This work was funded by the NSF and the WHOI Ocean and Climate Change Institute

Effects of bottom boundary placement on subsurface heat storage: Implications for climate model simulations

A one-dimensional soil model is used to estimate the influence of the position of the bottom boundary condition on heat storage calculations in land-surface components of General Circulation Models (GCMs). It is shown that shallow boundary conditions reduce the capacity of the global continental subsurface to store heat by as much as 1.0 x 10²³ Joules during a 110-year simulation with a 10 m bottom boundary. The calculations are relevant for GCM projections that employ land-surface components with shallow bottom boundary conditions, typically ranging between 3 to 10 m. These shallow boundary conditions preclude a large amount of heat from being stored in the terrestrial subsurface, possibly allocating heat to other parts of the simulated climate system. The results show that climate models of any complexity should consider the potential for subsurface heat storage whenever choosing a bottom boundary condition in simulations of future climate change

Cardiovascular Disease and Type 2 Diabetes in Evolutionary Perspective: A Critical Role for Helminths?

Heart disease and type 2 diabetes are commonly believed to be rare among contemporary subsistencelevel human populations, and by extension prehistoric populations. Although some caveats remain, evidence shows these diseases to be unusual among well-studied hunter-gatherers and other subsistence populations with minimal access to healthcare. Here we expand on a relatively new proposal for why these and other populations may not show major signs of these diseases. Chronic infections, especially helminths, may offer protection against heart disease and diabetes through direct and indirect pathways. As part of a strategy to insure their own survival and reproduction, helminths exert multiple cardio-protective effects on their host through their effects on immune function and blood lipid metabolism. Helminths consume blood lipids and glucose, alter lipid metabolism, and modulate immune function towards Th-2 polarization—which combined can lower blood cholesterol, reduce obesity, increase insulin sensitivity, decrease atheroma progression, and reduce likelihood of atherosclerotic plaque rupture. Traditional cardiometabolic risk factors, coupled with the mismatch between our evolved immune systems and modern, hygienic environments may interact in complex ways. In this review, we survey existing studies in the non-human animal and human literature, highlight unresolved questions and suggest future directions to explore the role of helminths in the etiology of cardio-metabolic disease