Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders

A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders

Fire resistant materials based on argilite or metakaolin as a refractory geopolymer

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Antennas and absorbing materials based on geopolymers

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An evaluation framework for event detection using a morphological model of acoustic scenes

This paper introduces a model of environmental acoustic scenes which adopts a morphological approach by ab-stracting temporal structures of acoustic scenes. To demonstrate its potential, this model is employed to evaluate the performance of a large set of acoustic events detection systems. This model allows us to explicitly control key morphological aspects of the acoustic scene and isolate their impact on the performance of the system under evaluation. Thus, more information can be gained on the behavior of evaluated systems, providing guidance for further improvements. The proposed model is validated using submitted systems from the IEEE DCASE Challenge; results indicate that the proposed scheme is able to successfully build datasets useful for evaluating some aspects the performance of event detection systems, more particularly their robustness to new listening conditions and the increasing level of background sounds.Research project partly funded by ANR-11-JS03-005-01