Monitoring the hydrological balance of a landslide-prone slope covered by pyroclastic deposits over limestone fractured bedrock

Many mountainous areas in Campania, Southern Italy, are characterized by steep slopes covered by loose unsaturated pyroclastic deposits laying upon fractured limestone bedrock. The soil covers are mainly constituted by layers of ashes and pumices. Large and intense rainfall events trigger shallow landslides, often turning into debris flows that cause huge damage and casualties. The slope of Cervinara, around 40 km Northeast of Naples, was involved in a catastrophic flowslide on 16 December 1999, triggered by a rainstorm of 325 mm in 48 h. To capture the main effects of precipitation on the slope stability, hydro-meteorological monitoring activities have been carried out at the slope to assess the water balance for three years (2017–2020). The field monitoring data allowed the identification of the complex hydrological processes involving the unsaturated pyroclastic soil and the shallow groundwater system developing in the limestone bedrock, which control the conditions that potentially predispose the slope to landslide triggering. Specifically, late autumn has been identified as the potentially most critical period, when slope drainage processes are not yet effective, and soil covers already receive large amounts of precipitation

Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological evidence of joint damage. Mice heterozygous for PAR-2 gene disruption showed an intermediate phenotype. PAR-2 expression, normally limited to endothelial cells in small arterioles, was substantially upregulated 2 weeks after induction of inflammation, both in synovium and in other periarticular tissues. PAR-2 agonists showed potent proinflammatory effects as intra-articular injection of ASKH95, a novel synthetic PAR-2 agonist, induced prolonged joint swelling and synovial hyperemia. Given the absence of the chronic inflammatory response in the PAR-2-deficient mice, our findings demonstrate a key role for PAR-2 in mediating chronic inflammation, thereby identifying a novel and important therapeutic target for the management of chronic inflammatory diseases such as rheumatoid arthritis

Detection of an atmosphere around the super-Earth 55 Cancri e

We report the analysis of two new spectroscopic observations of the super-Earth 55 Cancri e, in the near infrared, obtained with the WFC3 camera onboard the HST. 55 Cancri e orbits so close to its parent star, that temperatures much higher than 2000 K are expected on its surface. Given the brightness of 55 Cancri, the observations were obtained in scanning mode, adopting a very long scanning length and a very high scanning speed. We use our specialized pipeline to take into account systematics introduced by these observational parameters when coupled with the geometrical distortions of the instrument. We measure the transit depth per wavelength channel with an average relative uncertainty of 22 ppm per visit and find modulations that depart from a straight line model with a 6$\sigma$ confidence level. These results suggest that 55 Cancri e is surrounded by an atmosphere, which is probably hydrogen-rich. Our fully Bayesian spectral retrieval code, T-REx, has identified HCN to be the most likely molecular candidate able to explain the features at 1.42 and 1.54 $\mu$m. While additional spectroscopic observations in a broader wavelength range in the infrared will be needed to confirm the HCN detection, we discuss here the implications of such result. Our chemical model, developed with combustion specialists, indicates that relatively high mixing ratios of HCN may be caused by a high C/O ratio. This result suggests this super-Earth is a carbon-rich environment even more exotic than previously thought.Comment: 10 pages, 10 figures, 4 tables, Accepted for publication in Ap

Topological field theory and physics

Topological Yang-Mills theory with the Belavin-Polyakov-Schwarz-Tyupkin $SU(2)$ instanton is solved completely, revealing an underlying multi-link intersection theory. Link invariants are also shown to survive the coupling to a certain kind of matter (hyperinstantons). The physical relevance of topological field theory and its invariants is discovered. By embedding topological Yang-Mills theory into pure Yang-Mills theory, it is shown that the topological version TQFT of a quantum field theory QFT allows us to formulate consistently the perturbative expansion of QFT in the topologically nontrivial sectors. In particular, TQFT classifies the set of good measures over the instanton moduli space and solves the inconsistency problems of the previous approaches. The qualitatively new physical implications are pointed out. Link numbers in QCD are related to a non abelian analogoue of the Aharonov-Bohm effect.Comment: 23 pages, 1 figure. Revision: additional explanation

Nickel (0) complexes as promising chemosensors for detecting the “cork taint” in wine

2,4,6-Trichloroanisole (TCA) is well recognized as one of the most responsible molecules of cork taint, an organoleptic defect of wine which represents a serious problem for wine industries. Up to now, very few examples of TCA-biosensors have been developed and we report herein a promising nickel (0) complex that can be employed as chemosensor for the TCA detection in cork stoppers. Among the three Ni (0) complexes studied in this work, complex Ni(0)(BINAP)(η2-PhCN) (2) showed the best reactivity towards pure TCA affording the oxidative addition product 4 in four hours at room temperature. Compound 4 represents an appealing probe for the indirect quantification of TCA due to the presence of the characteristic UV-adsorption band at 444 nm. Statistical studies on real samples confirmed that the presence of TCA can be detected by employing UV-Visible spectroscopy, as demonstrated by PCA analyses which allowed distinguishing TCA-contaminated samples from non-contaminated ones. Even if the present study has to be considered a preliminary approach for the realization of a chemosensor usable in real systems, the here reported Ni (0)-based sensing procedure represents the first examples of TCA chemical detection

Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats.

Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both for human health and several animal species, also representing a cancer threat to humans. Curcumin (CURC) is a natural polyphenol that has anti-apoptotic, anti-inflammatory, and antioxidant effects. The aim of this study was to investigate the cytoprotective effect of CURC against OTA-induced nephrotoxicity and hepatotoxicity through the study of the nitrosative stress, pro-inflammatory cytokines, and deoxyribonucleic acid (DNA) damage. Sprague Dawley rats were daily treated with CURC (100 mg/kg b.w.), OTA (0.5 mg/kg b.w), or CURC with OTA by oral gavage for 14 days. Our results demonstrated that OTA exposure was associated with significant increase of pro-inflammatory and DNA oxidative-damage biomarkers. Moreover, OTA induced the inducible nitric oxide synthase, (iNOS) resulting in increased nitric oxide (NO) levels both in kidney and liver. The co-treatment OTA + CURC counteracted the harmful effects of chronic OTA treatment by regulating inflammation, reducing NO levels and oxidative DNA damage in kidney and liver tissues. Histology revealed that OTA + CURC treatment determinates mainly an Iba1+ macrophagic infiltration with fewer CD3+ T-lymphocytes in the tissues. In conclusion, we evidenced that CURC exerted cytoprotective and antioxidant activities against OTA-induced toxicity in rats

NSHT: New Smart Hybrid Transducer for Structural and Geotechnical Applications

This work describes the application of a new transducer prototype for continuous monitoring in both the structural and geotechnical fields. The transducer is synthetically constituted by a wire of optical fiber embedded between two fiber tapes (fiberglass or carbon fiber) and glued by a matrix of polyester resin. The fiber optical wire ends have been connected to a control unit whose detection system is based on Brillouin optical time-domain frequency analysis. Three laboratory tests were carried out to evaluate the sensor's reliability and accuracy. In each experiment, the transducer was applied to a sample of inclinometer casing sets in different configurations and with different constraint conditions. The experimental collected data were compared with theoretical models and with data obtained from the use of different measuring instruments to perform validation and calibration of the transducer at the same time. Several diagrams can compare the transducer and highlight its suitability for the monitoring and maintenance of structures. The characteristic of the transducer suggests its use as a mixed system for reinforcing and monitoring, especially in the lifetime maintenance of critical infrastructures such as transportation and service networks, and historical heritag

Potential Approaches Versus Approved or Developing Chronic Myeloid Leukemia Therapy.

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, continued use of these inhibitors has contributed to the increase in clinical resistance and the persistence of resistant leukemic stem cells (LSCs). So, there is an urgent need to introduce additional targeted and selective therapies to eradicate quiescent LSCs, and to avoid the relapse and disease progression. Here, we focused on emerging BCR-ABL targeted and non-BCR-ABL targeted drugs employed in clinical trials and on alternative CML treatments, including antioxidants, oncolytic virus, engineered exosomes, and natural products obtained from marine organisms that could pave the way for new therapeutic approaches for CML patients

Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats

Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, and immunotoxicity to both humans and several animal species. The severity of the liver damage caused depends on both dose and duration of exposure. Several studies have suggested that oxidative stress might contribute to increasing the hepatotoxicity of OTA, and several antioxidants, including curcumin (CURC), have been tested to counteract the toxic hepatic action of OTA in various classes of animals. Therefore, the present study was designed to evaluate the protective effect of CURC, a bioactive compound with different therapeutic properties on hepatic injuries caused by OTA in rat animal models. CURC effects were examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. At the end of the experiment, rats treated with OTA showed alterations in biochemical parameters and oxidative stress in the liver. CURC dosing significantly attenuated oxidative stress and lipid peroxidation versus the OTA group. Furthermore, liver histological tests showed that CURC reduced the multifocal lymphoplasmacellular hepatitis, the periportal fibrosis, and the necrosis observed in the OTA group. This study provides evidence that CURC can preserve OTA-induced oxidative damage in the liver of rat