Clinical study in phase- contrast mammography: image-quality analysis

The first clinical study of phase-contrast mammography (PCM) with synchrotron radiation was carried out at the Synchrotron Radiation for Medical Physics beamline of the Elettra synchrotron radiation facility in Trieste (Italy) in 2006–2009. The study involved 71 patients with unresolved breast abnormalities after conventional digital mammography and ultrasonography exams carried out at the Radiology Department of Trieste University Hospital. These cases were referred for mammography at the synchrotron radiation facility, with images acquired using a propagation-based phase-contrast imaging technique. To investigate the contribution of phase-contrast effects to the image quality, two experienced radiologists specialized in mammography assessed the visibility of breast abnormalities and of breast glandular structures. The images acquired at the hospital and at the synchrotron radiation facility were compared and graded according to a relative seven-grade visual scoring system. The statistical analysis highlighted that PCM with synchrotron radiation depicts normal structures and abnormal findings with higher image quality with respect to conventional digital mammography

Contribution of Each Leg to the Control of Unperturbed Bipedal Stance in Lower Limb Amputees: New Insights Using Entropy

The present study was designed to assess the relative contribution of each leg to unperturbed bipedal posture in lower limb amputees. To achieve this goal, eight unilateral traumatic trans-femoral amputees (TFA) were asked to stand as still as possible on a plantar pressure data acquisition system with their eyes closed. Four dependent variables were computed to describe the subject's postural behavior: (1) body weight distribution, (2) amplitude, (3) velocity and (4) regularity of centre of foot pressure (CoP) trajectories under the amputated (A) leg and the non-amputated (NA) leg. Results showed a larger body weight distribution applied to the NA leg than to the A leg and a more regular CoP profiles (lower sample entropy values) with greater amplitude and velocity under the NA leg than under the A leg. Taken together, these findings suggest that the NA leg and the A leg do not equally contribute to the control of unperturbed bipedal posture in TFA. The observation that TFA do actively control unperturbed bipedal posture with their NA leg could be viewed as an adaptive process to the loss of the lower leg afferents and efferents because of the unilateral lower-limb amputation. From a methodological point of view, these results demonstrate the suitability of computing bilateral CoP trajectories regularity for the assessment of lateralized postural control under pathological conditions

Old age and supersolar metallicity in a massive z ∼ 1.4 early-type galaxy from VLT/X-Shooter spectroscopy

We present the first estimate of age, stellar metallicity and chemical abundance ratios, for an individual early-type galaxy at high-redshift (z = 1.426) in the COSMOS (Cosmological Evolution Survey) field. Our analysis is based on observations obtained with the X-Shooter instrument at the Very Large Telescope (VLT), which cover the visual and near-infrared spectrum at high (R > 5000) spectral resolution. We measure the values of several spectral absorptions tracing chemical species, in particular magnesium and iron, besides determining the age-sensitive D4000 break. We compare the measured indices to stellar population models, finding good agreement. We find that our target is an old (t > 3 Gyr), high-metallicity ([Z/H] > 0.5) galaxy which formed its stars at zform >5 within a short time-scale ∼0.1 Gyr, as testified by the strong [α/Fe] ratio (>0.4), and has passively evolved in the first >3-4 Gyr of its life. We have verified that this result is robust against the choice and number of fitted spectral features, and stellar population model. The result of an old age and high-metallicity has important implications for galaxy formation and evolution confirming an early and rapid formation of the most massive galaxies in the Universe