292 research outputs found
Long sentenced women prisoners: Rights, risks and rehabilitation
This paper re-examines critically the role of rehabilitative interventions for a seriously neglected group of prisoners: women serving long sentences. Drawing on empirical research conducted in a democratic therapeutic community in a womenâs prison in the south of England, it considers how far established criticisms identify insuperable difficulties that exacerbate existing harms and inequalities. It argues that evidence can be adduced to support rehabilitative interventions that are not predominantly concerned with the reduction of criminal risk but which provide tangible benefits to the personal wellbeing of women in prison and may increase their prospects of integration post release. It explores how such rehabilitative policies and practices could be supported and protected from attrition by penal power, by embedding them within a doctrine of human rights. By challenging and replacing prevalent assumptions and justifications that uphold existing power relations in prisons, we argue that a specific duty of care, owed by the prison service to women serving long sentences, can protect, support and re-imagine their right to rehabilitative opportunities
Bootstrapping trust and stereotypes with tags
In real-world environments, cooperation often emerges amongst agents who are observably similar. Estimating the expected behaviour of another agent is a challenging problem, particularly for new agents who have little or no experience of others. In this paper, we show how observable features can be used to find similar, and hence cooperative, partners. Our contribution extends trust and stereotype approaches, to include comparisons and learning of observable features, called tags. In environments where no reciprocity exists (or where there have been insuf- ficient interactions for reciprocity to take effect) tags have been used to encourage cooperation. The only information available to an agent early in its life is knowledge of its own tags and behaviour. We assume that agents who are observably similar will be behaviourally similar too. Agents use reinforcement learning to take advantage of as much available information as possible, until sufficient experience has been gathered for more established trust and stereotype models to be built. Our results show that using tags improves agentsâ rewards in the early stages of their lifetime when used prior to established stereotype and trust algorithms. We demonstrate that tags are successful in supporting cooperation, even when agent behaviour is independent of the partner, because the approach correctly identifies similar agents. Good agents are able to select partners who will act as they do, while bad agents avoid those who are observably similar
Measurement of the electron electric dipole moment using YbF molecules
The most sensitive measurements of the electron electric dipole moment d_e
have previously been made using heavy atoms. Heavy polar molecules offer a
greater sensitivity to d_e because the interaction energy to be measured is
typically 10^3 times larger than in a heavy atom. We report the first
measurement of this kind, for which we have used the molecule YbF. Together,
the large interaction energy and the strong tensor polarizability of the
molecule make our experiment essentially free of the systematic errors that
currently limit d_e measurements in atoms. Our first result d_e = (- 0.2 \pm
3.2) x 10^-26 e.cm is less sensitive than the best atom measurement, but is
limited only by counting statistics and demonstrates the power of the method.Comment: 4 pages, 4 figures. v2. Minor corrections and clarifications made in
response to referee comment
Electrospun gelatin-based scaffolds as a novel 3D platform to study the function of contractile smooth muscle cells in vitro
Contractile dysfunction of smooth muscle (SM) is a feature of chronic cardiovascular, respiratory and gastro-intestinal diseases. Owing to the low availability of human ex vivo tissue for the assessment of SM contractile function, the aim of this study was to develop a novel in vitro SM model that possesses the ability to contract, and a method to measure its contractility. A range of electrospun scaffolds were produced from crosslinked gelatin and methacrylated gelatin (GelMA), generating highly aligned scaffolds with average fibre diameters ranging from 200 nm to several micrometres. Young's moduli of the scaffolds ranged from 1x105 to 1x107 Pa. Primary aortic smooth muscle cells (AoSMCs; rat) cells readily adhered to and proliferated on the fibrous scaffolds for up to 10 days. They formed highly aligned populations following the topographical cues of the aligned scaffolds and stained positive for SM markers, indicating a contractile phenotype. Cell-seeded GelMA scaffolds were able, upon stimulation with uridine 5'-triphosphate (UTP), to contract and their attachment to a force transducer allowed the force of contraction to be measured. Hence, these electrospun GelMA fibres can be used as biomimetic scaffolds for SM cell culture and in vitro model development, and enables the contractile forces generated by the aligned three-dimensional sheet of cells to be directly measured. This will supplement in vitro drug screening tools and facilitate discovery of disease mechanisms
Search for the electric dipole moment of the electron with thorium monoxide
The electric dipole moment of the electron (eEDM) is a signature of
CP-violating physics beyond the Standard Model. We describe an ongoing
experiment to measure or set improved limits to the eEDM, using a cold beam of
thorium monoxide (ThO) molecules. The metastable state in ThO
has important advantages for such an experiment. We argue that the statistical
uncertainty of an eEDM measurement could be improved by as much as 3 orders of
magnitude compared to the current experimental limit, in a first-generation
apparatus using a cold ThO beam. We describe our measurements of the state
lifetime and the production of ThO molecules in a beam, which provide crucial
data for the eEDM sensitivity estimate. ThO also has ideal properties for the
rejection of a number of known systematic errors; these properties and their
implications are described.Comment: v2: Equation (11) correcte
Qualitative Human Immunodeficiency Virus RNA Analysis of Dried Blood Spots for Diagnosis of Infections in Infants
The Gen-Probe Aptima human immunodeficiency virus type 1 (HIV-1) RNA assay was adapted for the diagnosis of HIV infection in infants by using dried blood spots. The assay was 99% sensitive (128/129) and 100% specific (162/162). This may prove useful in resource-limited settings, since it precludes the need for a phlebotomist and maintenance of a cold chain
Plant-Expressed Cocaine Hydrolase Variants of Butyrylcholinesterase Exhibit Altered Allosteric Effects of Cholinesterase Activity and Increased Inhibitor Sensitivity
Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationally designed to increase the enzymeâs ability to hydrolyze the psychoactive enantiomer of cocaine. These variants were cloned, and then expressed using the magnICON transient expression system in plants and their enzymatic properties were investigated. In particular, we explored the effects that these site-directed mutations have over the enzyme kinetics with various substrates of BChE. We further compared the affinity of various anticholinesterases including organophosphorous nerve agents and pesticides toward these BChE variants relative to the wild type enzyme. In addition to serving as a therapy for cocaine addiction-related diseases, enhanced bioscavenging against other harmful agents could add to the practicality and versatility of the plant-derived recombinant enzyme as a multivalent therapeutic
Limits on the monopole magnetic field from measurements of the electric dipole moments of atoms, molecules and the neutron
A radial magnetic field can induce a time invariance violating electric
dipole moment (EDM) in quantum systems. The EDMs of the Tl, Cs, Xe and Hg atoms
and the neutron that are produced by such a field are estimated. The
contributions of such a field to the constants, of the T,P-odd
interactions and are also estimated for the TlF, HgF and YbF molecules (where
() is the electron (nuclear) spin and is the molecular
axis). The best limit on the contact monopole field can be obtained from the
measured value of the Tl EDM. The possibility of such a field being produced
from polarization of the vacuum of electrically charged magnetic monopoles
(dyons) by a Coulomb field is discussed, as well as the limit on these dyons.
An alternative mechanism involves chromomagnetic and chromoelectric fields in
QCD.Comment: Uses RevTex, 16 pages, 4 postscript figures. An explanation of why
there is no orbital contribution to the EDM has been added, and the
presentation has been improved in genera
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