Reversible GANs for Memory-efficient Image-to-Image Translation

The Pix2pix and CycleGAN losses have vastly improved the qualitative and quantitative visual quality of results in image-to-image translation tasks. We extend this framework by exploring approximately invertible architectures which are well suited to these losses. These architectures are approximately invertible by design and thus partially satisfy cycle-consistency before training even begins. Furthermore, since invertible architectures have constant memory complexity in depth, these models can be built arbitrarily deep. We are able to demonstrate superior quantitative output on the Cityscapes and Maps datasets at near constant memory budget

The case for strategic international alliances to harness nutritional genomics for public and personal health

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countrie

Hoe kan men belasting dragen?

De verabsolutering van het draagkrachtbeginsel leidt in dit verhaal van Bordewijk tot stigmatisering van minvermogenden, onzekerheid voor de burgers, verstoring van het maatschappelijk en economische verkeer, gebrekkige rechtsbescherming, wisselende belastingopbrengsten, etc. Dat is een hoge prijs. Er is maar een conclusie mogelijk: zo moet het niet. Hoe moet het dan wel? Dat valt niet eenvoudig aan te geven en dat is als gezegd ook niet de bedoeling van Bordewijk. Wel kunnen we zeggen dat het draagkrachtbeginsel een deugd naast andere deugden van een belastingstelsel is. Er zijn meerdere idealen, waarden en beginselen die nastrevenswaardig zijn. De wetgever zal steeds naar een evenwicht in die pluraliteit moeten zoeken. Geen monomane fixatie maar verschillende idealen hoog houden en in evenwicht brengen, dat is de opdracht van de wetgever. Daarbij dient bovendien rekening te worden gehouden met beperkende randvoorwaarden. Ook wetgeven is dus een voortdurend zoeken naar het juiste evenwicht

THE ASSOCIATION BETWEEN BODY COMPOSITION AND 24-HOUR GLUCOSE RHYTHMS IN AN AGING POPULATION WITHOUT DIABETES

Pathophysiology, epidemiology and therapy of agein

AMBULANT 24-HOUR GLUCOSE RHYTHMS IN CHRONOLOGICAL AGE AND FAMILIAL LONGEVITY IN INDIVIDUALS WITHOUT DIABETES

Diabetes mellitus: pathophysiological changes and therap

Being Active, Engaged, and Healthy:Older Persons' Plans and Wishes to Age Successfully

Objectives: This study took an emic multidimensional approach on successful aging and examined what older people consider important to age successfully by asking them about their plans and wishes (PWs). Associations between participants' demographics, health status, working life, social contacts, life satisfaction, and their PWs were investigated. Method: An online questionnaire was completed by 649 older individuals (55-90 years). Conceptual content analysis was performed to identify important categories in PWs. Quantitative analyses were conducted to examine associations between PWs and participants' characteristics. Results: Most mentioned PWs were related to activities, engagement with life, and health. Seventy-four participants (11.4%) expressed no PWs. Multivariate analysis revealed that having PWs was most strongly related to participants' life satisfaction. Older individuals with a higher life satisfaction indicated significantly more often to have PWs than individuals with a lower life satisfaction. Discussion: The majority of older people desire an active, engaged, and healthy life. PWs were variable and personal, which endorses an emic, multidimensional approach to successful aging. Knowledge on what older individuals find important in their lives and what they want to achieve can assist older individuals in setting and attaining their goals toward aging well

Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial

Pathophysiology, epidemiology and therapy of agein