76 research outputs found

    Stationary rotation of the unbalanced rotor with the liquid autobalancing device under action of external friction forces

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    Influence of external friction forces on rotation of the rotor with the liquid autobalancing device is considered. The liquid in the balancing chamber at stationary movement rotates together with the rotor as solids. Analytical expressions for deflection of the shaft, unbalance of the system and the necessary rotating moment from the engine providing rotation with set speed are received

    Stationary rotation stability of unbalanced rotor with autobalancing device with liquid on flexible shaft

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    The condition of rotor rotation stability with liquid autobalancing device consisting of chamber, float and incompressible homogeneous liquid filling the space between them has been obtained. The restoring force and forces of internal and external friction take effect on the rotor. The latter depend linearly respectively on strain rate and absolute velocity of rotor connection point to the shaf

    Investigation of Input Signal Curve Effect on Formed Pulse of Hydraulic-Powered Pulse Machine

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    Well drilling machines should have as high efficiency factor as it is possible. This work proposes factors that are affected by change of input signal pulse curve. A series of runs are conducted on mathematical model of hydraulic-powered pulse machine. From this experiment, interrelations between input pulse curve and construction parameters are found. Results of conducted experiment are obtained with the help of the mathematical model, which is created in Simulink Matlab

    Optimization of hole generation in Ti/CFRP stacks

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    The article aims to describe methods for improving the surface quality and hole accuracy in Ti/CFRP stacks by optimizing cutting methods and drill geometry. The research is based on the fundamentals of machine building, theory of probability, mathematical statistics, and experiment planning and manufacturing process optimization theories. Statistical processing of experiment data was carried out by means of Statistica 6 and Microsoft Excel 2010. Surface geometry in Ti stacks was analyzed using a Taylor Hobson Form Talysurf i200 Series Profilometer, and in CFRP stacks - using a Bruker ContourGT-K1 Optical Microscope. Hole shapes and sizes were analyzed using a Carl Zeiss CONTURA G2 Measuring machine, temperatures in cutting zones were recorded with a FLIR SC7000 Series Infrared Camera. Models of multivariate analysis of variance were developed. They show effects of drilling modes on surface quality and accuracy of holes in Ti/CFRP stacks. The task of multicriteria drilling process optimization was solved. Optimal cutting technologies which improve performance were developed. Methods for assessing thermal tool and material expansion effects on the accuracy of holes in Ti/CFRP/Ti stacks were developed

    ДСйствиС противовирусных миРНК Π½Π° Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΊΡƒ Ρ†ΠΈΡ‚ΠΎΠΊΠΈΠ½ΠΎΠ² in vitro

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    Objectives. To evaluate the dynamics of the expression level of IL-1Ξ² and IL-28Ξ² (IFN-Ξ»3) genes as a result of complex knockdown of some cellular genes, whose expression products play an important role in the reproduction of the influenza virus.Methods. Following the collection of virus-containing liquid and cell lysate within three days from the moment of transfection and infection, the intensity of viral reproduction was assessed using the cytopathic effect titration method. The concentration of viral ribonucleic acid (vRNA) and change in the expression of IL-1Ξ² and IL-28Ξ² (IFN-Ξ»3) were determined by real-time reverse transcription quantitative polymerase chain reaction (real-time RT-qPCR). The nonparametric Mann–Whitney test was used to statistically calculate significant differences between groups.Results. The use of each small interfering ribonucleic acid (siRNA) complex led to a decrease in viral reproduction on the first day at the multiplicity of infection (MOI) of 0.001. The use of complex A (FLT4.2 + Nup98.1) and D (FLT4.2 + Nup98.1 + Nup205) led to a decrease in viral titer by 2.8 lgTCID50/mL and by 2.1 lgTCID50/mL relative to the use of nonspecific L2 siRNA and viral control (p ≀ 0.05). Transfection of complexes B (Nup98.1 + Nup205) and C (FLT4.2 + Nup205) also reduced the viral titer by 1.5 lgTCID50/mL and 1.8 lgTCID50/mL relative to nonspecific L2 siRNA and viral control (p ≀ 0.05). When conducting real-time RT-qPCR, a significant decrease in the concentration of viral RNA was also noted. When using complexes B, C, and D, the concentration of vRNA decreased on the first day by 14.5, 4.1, and 15 times, respectively. On the second day, a decrease in vRNA was observed in cells with B and D complexes by 17.1 and 18.3 times (p ≀ 0.05). Along with a decrease in the viral titer and vRNA, an increase in the expression of the IL-1Ξ² and IL-28Ξ² genes was observed on the first day when using all siRNA complexes relative to nonspecific and viral controls (p ≀ 0.05). On the second day, an increase was also observed in cells with A and D complexes, while on the third day, there was an increase in the expression of these genes in cells with complex D (p ≀ 0.05).Conclusions. The use of siRNA complexes is shown to have a pronounced antiviral effect while simultaneously suppressing the activity of cellular genes (FLT4, Nup98 and Nup205). In parallel, the transfection of complexes that block the formation of expression products necessary for viral reproduction is demonstrated to lead to an increase in the level of expression of the IL-1Ξ² and IL-28Ξ² genes. These results indicate not only that the use of siRNA has antiviral activity, but also immunomodulatory activity, which can contribute to a more effective immune response of the body.Π¦Π΅Π»ΠΈ. ΠžΡ†Π΅Π½ΠΈΡ‚ΡŒ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡƒ уровня экспрСссии Π³Π΅Π½ΠΎΠ² IL-1Ξ² ΠΈ IL-28Ξ² (IFN-Ξ»3) Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ комплСксного Π½ΠΎΠΊΠ΄Π°ΡƒΠ½Π° Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… Π³Π΅Π½ΠΎΠ², Ρ‡ΡŒΠΈ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ экспрСссии ΠΈΠ³Ρ€Π°ΡŽΡ‚ Π²Π°ΠΆΠ½ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π² Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ вируса Π³Ρ€ΠΈΠΏΠΏΠ°.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ΠΈΡ€ΡƒΡΡΠΎΠ΄Π΅Ρ€ΠΆΠ°Ρ‰ΡƒΡŽ ΠΆΠΈΠ΄ΠΊΠΎΡΡ‚ΡŒ ΠΈ ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΉ Π»ΠΈΠ·Π°Ρ‚ ΠΎΡ‚Π±ΠΈΡ€Π°Π»ΠΈ Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 3-Ρ… Π΄Π½Π΅ΠΉ с ΠΌΠΎΠΌΠ΅Π½Ρ‚Π° трансфСкции ΠΈ зараТСния ΠΈ ΠΎΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΈΠ½Ρ‚Π΅Π½ΡΠΈΠ²Π½ΠΎΡΡ‚ΡŒ вирусной Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ титрования ΠΏΠΎ цитопатичСскому Π΄Π΅ΠΉΡΡ‚Π²ΠΈΡŽ. ΠšΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΡŽ вирусной Ρ€ΠΈΠ±ΠΎΠ½ΡƒΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΠΎΠΉ кислоты (вРНК) ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ экспрСссии IL-1Ξ² ΠΈ IL-28Ξ² (IFN-Ξ»3) опрСдСляли ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠΎΠ±Ρ€Π°Ρ‚Π½ΠΎΠΉ транскрипции ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°Π·Π½ΠΎΠΉ Ρ†Π΅ΠΏΠ½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ Π² Ρ€Π΅ΠΆΠΈΠΌΠ΅ Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ (ОВ-ПЦР-Π Π’). Для вычислСния статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρƒ Π³Ρ€ΡƒΠΏΠΏΠ°ΠΌΠΈ использовали нСпарамСтричСский ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠΉ Манна-Π£ΠΈΡ‚Π½ΠΈ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ИспользованиС ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ комплСкса ΠΌΠ°Π»Ρ‹Ρ… ΠΈΠ½Ρ‚Π΅Ρ€Ρ„Π΅Ρ€ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… РНК (миРНК) ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ ΠΊ сниТСнию вирусной Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ Π½Π° 1-Π΅ сутки ΠΏΡ€ΠΈ мноТСствСнности зараТСния 0.001. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ комплСксов A (FLT4.2 + Nup98.1) ΠΈ D (FLT4.2 + Nup98.1 + Nup205) ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ ΠΊ сниТСнию вирусного Ρ‚ΠΈΡ‚Ρ€Π° Π½Π° 2.8 lgΠ’Π¦Π”50/ΠΌΠ» ΠΈ Π½Π° 2.1 lgΠ’Π¦Π”50/ΠΌΠ» ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ примСнСния нСспСцифичСской миРНК L2 ΠΈ вирусного контроля (Ρ€ ≀ 0.05). Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ трансфСкции комплСксов B (Nup98.1 + Nup205) ΠΈ C (FLT4.2 + Nup205) вирусный Ρ‚ΠΈΡ‚Ρ€ Ρ‚Π°ΠΊΠΆΠ΅ сниТался Π½Π° 1.5 lgΠ’Π¦Π”50/ΠΌΠ» ΠΈ 1.8 lgΠ’Π¦Π”50/ΠΌΠ» соотвСтствСнно ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ нСспСцифичСской миРНК L2 ΠΈ вирусного контроля (Ρ€ ≀ 0.05). ΠŸΡ€ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ОВ-ПЦР-Π Π’ Ρ‚Π°ΠΊΠΆΠ΅ Π±Ρ‹Π»ΠΎ ΠΎΡ‚ΠΌΠ΅Ρ‡Π΅Π½ΠΎ достовСрноС ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ вРНК. ΠŸΡ€ΠΈ использовании комплСксов B, C ΠΈ D концСнтрация вРНК сниТалась Π½Π° 1-Π΅ сутки Π² 14.5, 4.1 ΠΈ 15.0 Ρ€Π°Π· соотвСтствСнно. На 2-Π΅ сутки Π² ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ… с комплСксами B ΠΈ D наблюдалось ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ вРНК Π² 17.1 ΠΈ 18.3 Ρ€Π°Π· (Ρ€ ≀ 0.05). Наряду со сниТСниСм вирусного Ρ‚ΠΈΡ‚Ρ€Π° ΠΈ вРНК наблюдалось ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ экспрСссии Π³Π΅Π½ΠΎΠ² IL-1Ξ² ΠΈ IL-28Ξ² Π½Π° 1-Π΅ сутки ΠΏΡ€ΠΈ использовании всСх комплСксов миРНК ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ нСспСцифичСского ΠΈ вирусного контроля (Ρ€ ≀ 0.05). На 2-Π΅ сутки Ρ‚Π°ΠΊΠΆΠ΅ наблюдалось ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ экспрСссии Π² ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ… с комплСксами A ΠΈ D, Π° Π½Π° Ρ‚Ρ€Π΅Ρ‚ΡŒΠΈ – Π² ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ… с комплСксом D (Ρ€ ≀0.05).Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ИсслСдованиС ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ комплСксов миРНК ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠΌΡƒ противовирусному эффСкту ΠΏΡ€ΠΈ ΠΎΠ΄Π½ΠΎΠ²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠΈ активности ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… Π³Π΅Π½ΠΎΠ² (FLT4, Nup98 ΠΈ Nup205). ΠŸΠ°Ρ€Π°Π»Π»Π΅Π»ΡŒΠ½ΠΎ с этим Π±Ρ‹Π»ΠΎ выявлСно, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈ трансфСкции комплСксов, Π±Π»ΠΎΠΊΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² экспрСссии, Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΡ‹Ρ… для вирусной Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ, ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ΡΡ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ экспрСссии Π³Π΅Π½ΠΎΠ² IL-1Ξ² ΠΈ IL-28Ξ². Π”Π°Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹Π΅ миРНК ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‚ Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ противовирусной, Π½ΠΎ Ρ‚Π°ΠΊΠΆΠ΅ ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΠΌΠΎΠ΄ΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ, Ρ‡Ρ‚ΠΎ способствуСт Π±ΠΎΠ»Π΅Π΅ эффСктивному ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠΌΡƒ ΠΎΡ‚Π²Π΅Ρ‚Ρƒ ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ°

    Phylogeny, phylogeography and hybridization of Caucasian barbels of the genus Barbus (Actinopterygii, Cyprinidae)

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    Phylogenetic relationships and phylogeography of six species of Caucasian barbels, the genus Barbus s. str., were studied based on extended geographic coverage and using mtDNA and nDNA markers. Based on 27 species studied, matrilineal phylogeny of the genus Barbus is composed of two clades ΒΏ (a) West European clade, (b) Central and East European clade. The latter comprises two subclades: (b1) Balkanian subclade, and (b2) Ponto-Caspian one that includes 11 lineages mainly from Black and Caspian Sea drainages. Caucasian barbels are not monophyletic and subdivided for two groups. The Black Sea group encompasses species from tributaries of Black Sea including re-erected B. rionicus and excluding B. kubanicus. The Caspian group includes B. ciscaucasicus, B. cyri (with B. goktschaicus that might be synonymized with B. cyri), B. lacerta from the Tigris-Euphrates basin and B. kubanicus from the Kuban basin. Genetic structure of Black Sea barbels was influenced by glaciation-deglaciation periods accompanying by freshwater phases, periods of migration and colonization of Black Sea tributaries. Intra- and intergeneric hybridization among Caucasian barbines was revealed. In the present study, we report about finding of B. tauricus in the Kuban basin, where only B. kubanicus was thought to inhabit. Hybrids between these species were detected based on both mtDNA and nDNA markers. Remarkably, Kuban population of B. tauricus is distant to closely located conspecific populations and we consider it as relic. We highlight revealing the intergeneric hybridization between evolutionary tetraploid (2n=100) B. goktschaicus and evolutionary hexaploid (2n=150) Capoeta sevangi in Lake Sevan.The study was supported by Russian Science Foundation (grant no. 15-14-10020); final stage of the study was supported by Russian Foundation for Basic Research (grants nos. 18-54-05003 and 19-04-00719)

    Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

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    Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. Β© 2023 by the authors.23-15-20040; Russian Science Foundation, RSFThis work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040)

    Π›Π΅Ρ‡Π΅Π½ΠΈΠ΅ экспираторного стСноза Ρ‚Ρ€Π°Ρ…Π΅ΠΈ Π² сочСтании с бронхоэктатичСской болСзнью Ρƒ Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚Π° донорских Π»Π΅Π³ΠΊΠΈΡ… (ΠΏΠ΅Ρ€Π²ΠΎΠ΅ наблюдСниС Π² Российской Π€Π΅Π΄Π΅Ρ€Π°Ρ†ΠΈΠΈ)

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    Lung transplantation is the final treatment option for end-stage lung failure. In 2019, 63,530 lung transplants wereΒ performed worldwide [13]. Due to the variety of diseases causing patients to resort to lung transplant surgeries,Β there is a wide range of different complications and conditions that are subject to an individual clinical approachΒ to determine treatment tactics. Each case is of great clinical interest due to the small amount of these operationsΒ and the complexity of postoperative rehabilitation, which requires a multidisciplinary approach [12]. We present aΒ report on a surgical treatment of expiratory tracheal stenosis in combination with bronchiectasis in a lung recipient.Врансплантация Π»Π΅Π³ΠΊΠΈΡ… – СдинствСнный Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ лСчСния Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ… Π² Ρ‚Π΅Ρ€ΠΌΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉΒ ΡΡ‚Π°Π΄ΠΈΠΈ Π΄Ρ‹Ρ…Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ нСдостаточности. К 2019 Π³ΠΎΠ΄Ρƒ Π² ΠΌΠΈΡ€Π΅ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΎ 63 530 трансплантаций Π»Π΅Π³ΠΊΠΈΡ… [13].Β Π’ силу многообразия Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, приводящих ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΊ пСрСсадкС Π»Π΅Π³ΠΊΠΈΡ…, сущСствуСт ΡˆΠΈΡ€ΠΎΠΊΠΈΠΉΒ ΡΠΏΠ΅ΠΊΡ‚Ρ€ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ослоТнСний ΠΈ состояний, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΠΎΠ΄Π»Π΅ΠΆΠ°Ρ‚ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠΌΡƒ клиничСскому подходу для опрСдСлСния Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΈ лСчСния. ΠšΠ°ΠΆΠ΄Ρ‹ΠΉ случай прСдставляСт ΠΎΠ³Ρ€ΠΎΠΌΠ½Ρ‹ΠΉ интСрСс с клиничСской точки зрСния Π² силу нСбольшого количСства Π΄Π°Π½Π½Ρ‹Ρ… ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ ΠΈ слоТности послСопСрационной Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΈ,Β Ρ‚Ρ€Π΅Π±ΡƒΡŽΡ‰Π΅ΠΉ ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠ΄ΠΈΡΡ†ΠΈΠΏΠ»ΠΈΠ½Π°Ρ€Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° [12]. ΠœΡ‹ прСдставляСм  клиничСскоС наблюдСниС хирургичСского лСчСния экспираторного стСноза Ρ‚Ρ€Π°Ρ…Π΅ΠΈ Π²Β  сочСтании с бронхоэктатичСской болСзнью Ρƒ пациСнта послС трансплантации Π»Π΅Π³ΠΊΠΈΡ…

    Врансплантация Π»Π΅Π³ΠΊΠΈΡ… ΠΏΡ€ΠΈ ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½ΠΎΠΉ Π»Π΅Π³ΠΎΡ‡Π½ΠΎΠΉ Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅Ρ€Ρ‚Π΅Π½Π·ΠΈΠΈ: особСнности ΠΏΠ΅Ρ€ΠΈΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π°

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    Lung transplantation (LT) for idiopathic pulmonary arterial hypertension (IPAH) now is the only radical treatment of this disease.Aim: to analyze own experience of performing LT in patients with IPAH.Materials and methods. 8 adult IPAH patients, who underwent LT between 2014 and october 2018, were included. In 7 of 8 patients undergoing bilateral lung transplantation on intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) with prolongation into the postoperative period.Results. VA ECMO support was prolonged into postoperative period 6 and 7 days respectively in 2 (25,0%) patients and 3 days in 6 (75,0%) patients. Hospital mortality in IPAH patients was 1.Conclusions. Own experience demonstrates that LT is an effective method of treatment in patients with IPAH. Hospital, 1- and 3-year survival rates for the patient collective were 87.5, 75.0 and 75.0% respectively.ΠŸΠ΅Ρ€Π²ΠΈΡ‡Π½Π°Ρ лСгочная Π°Ρ€Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½Π°Ρ гипСртСнзия (ΠŸΠ›ΠΠ“) – Π½Π΅ΠΎΠ±Ρ€Π°Ρ‚ΠΈΠΌΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, СдинствСнным ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ лСчСния ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ³ΠΎ являСтся трансплантация Π»Π΅Π³ΠΊΠΈΡ… (Π’Π›).ЦСль исслСдования: Π°Π½Π°Π»ΠΈΠ· собствСнного ΠΎΠΏΡ‹Ρ‚Π° выполнСния Π’Π› Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠŸΠ›ΠΠ“.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ исслСдованиС Π²ΠΊΠ»ΡŽΡ‡ΠΈΠ»ΠΈ 8 взрослых Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ², ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ Π±Ρ‹Π»Π° Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° Π’Π› Π² ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2014-Π³ΠΎ ΠΏΠΎ ΠΎΠΊΡ‚ΡΠ±Ρ€ΡŒ 2018 Π³. ВсСм Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚Π°ΠΌ Π±Ρ‹Π»Π° Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° двусторонняя ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Π°Ρ трансплантация Π»Π΅Π³ΠΊΠΈΡ…. Π£ 7 ΠΈΠ· 8 Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ² Π’Π› осущСствляли Π² условиях пСрифСричСской ВА ЭКМО.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π’ послСопСрационном ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ пСрвичная дисфункция 3-ΠΉ стСпСни ΠΏΠΎ классификации ISHLT Ρ€Π°Π·Π²ΠΈΠ»Π°ΡΡŒ Ρƒ 2 (25,0%) ΠΈΠ· 8 Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ², которая ΠΏΡ€ΠΎΡΠ²ΠΈΠ»Π°ΡΡŒ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒΡŽ прСкращСния ВА ЭКМО. ΠžΠ±Ρ‰Π°Ρ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ примСнСния ЭКМО Ρƒ этих ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² (n = 2) составила 6 ΠΈ 7 суток. Π£ Π΄Ρ€ΡƒΠ³ΠΈΡ… 6 (75,0%) Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ² проявлСния Ρ€Π°Π½Π½Π΅ΠΉ дисфункции пСрСсаТСнных Π»Π΅Π³ΠΊΠΈΡ… Π½Π΅ носили ΡΡ‚ΠΎΠ»ΡŒ напряТСнного Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π° (2-я ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ ΠΏΠΎ классификации ISHLT), ΠΈ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ послСопСрационной ВА ЭКМО составила 3 суток. Π“ΠΎΡΠΏΠΈΡ‚Π°Π»ΡŒΠ½Π°Ρ Π»Π΅Ρ‚Π°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Ρƒ Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ…, ΠΎΠΏΠ΅Ρ€ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρƒ ЛАГ, составила 1 наблюдСниС.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. БобствСнный ΠΎΠΏΡ‹Ρ‚ дСмонстрируСт, Ρ‡Ρ‚ΠΎ Π’Π› являСтся эффСктивной Π»Π΅Ρ‡Π΅Π±Π½ΠΎΠΉ ΠΌΠ΅Ρ€ΠΎΠΉ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠŸΠ›ΠΠ“ с показатСлями Π³ΠΎΡΠΏΠΈΡ‚Π°Π»ΡŒΠ½ΠΎΠΉ, 1- ΠΈ 3-Π»Π΅Ρ‚Π½Π΅ΠΉ выТиваСмости соотвСтствСнно 87,5; 75,0 ΠΈ 75,0%

    ИспользованиС ΠΊΡ€ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² трансплантации Π»Π΅Π³ΠΊΠΈΡ… ΠΈ сСрдСчно-Π»Π΅Π³ΠΎΡ‡Π½ΠΎΠ³ΠΎ комплСкса

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    Bronchial complications, along with development and progression of chronic dysfunction on the background of chronic rejection, are factors that reduce the quality and life of lung and heart-lung recipients. They also increase the frequency of hospitalizations. Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. This article demonstrates the experience of using cryotechnology in the diagnosis and treatment of complications in lung and heart-lung recipients.Π‘Ρ€ΠΎΠ½Ρ…ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ ослоТнСния наряду с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ ΠΈ прогрСссированиСм хроничСской дисфункции Π½Π° Ρ„ΠΎΠ½Π΅ хроничСского отторТСния ΡΠ²Π»ΡΡŽΡ‚ΡΡ Ρ„Π°ΠΊΡ‚ΠΎΡ€Π°ΠΌΠΈ, ΡΠ½ΠΈΠΆΠ°ΡŽΡ‰ΠΈΠΌΠΈ качСство ΠΈ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΆΠΈΠ·Π½ΠΈ Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ… ΠΈ сСрдСчно-Π»Π΅Π³ΠΎΡ‡Π½ΠΎΠ³ΠΎ комплСкса, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ²Π°ΡŽΡ‰ΠΈΠΌΠΈ частоту госпитализаций. Π’ основС примСнСния ΠΊΡ€ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π»Π΅ΠΆΠΈΡ‚ ΠΊΠΎΠ½Ρ‚Π°ΠΊΡ‚Π½ΠΎΠ΅ воздСйствиС Ρ‡Ρ€Π΅Π·Π²Ρ‹Ρ‡Π°ΠΉΠ½ΠΎ Π½ΠΈΠ·ΠΊΠΈΡ… Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€ Π½Π° ΠΎΡ€Π³Π°Π½Ρ‹ ΠΈ Ρ‚ΠΊΠ°Π½ΠΈ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΊΡ€ΠΈΠΎΠ·ΠΎΠ½Π΄Π°. Π’ Π΄Π°Π½Π½ΠΎΠΉ ΡΡ‚Π°Ρ‚ΡŒΠ΅ дСмонстрируСтся ΠΎΠΏΡ‹Ρ‚ примСнСния ΠΊΡ€ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² диагностикС ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ ослоТнСний Ρƒ Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚ΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ… ΠΈ сСрдСчно-Π»Π΅Π³ΠΎΡ‡Π½ΠΎΠ³ΠΎ комплСкса
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