23 research outputs found

    Carrier-bound Methotrexate. III.‡ Antiproliferative Activity of Macromolecular MTX Conjugates Against the Human HeLa and Colo Carcinoma Cell Lines

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    In continuation of studies in these laboratories aiming at the bioevaluation of macromolecular anticancer drug models, in vitro cytotoxicity screens are performed on several series of water-soluble polymer-methotrexate  conjugates. The methotrexate drug in these conjugates is bound through amide or ester linkages to water- soluble polyamide- or polyamidoamine-type carriers by previously developed anchoring techniques.Tests were  conducted against the HeLahumancervical carcinoma cell line generally considered to be drug-sensitive, and  against two variants of the rather refractory Colo 320 DM, a human colon adenocarcinoma line.KEYWORDS: Drug conjugation, Colo cell line, HeLa cell line, methotrexate, polyaspartamide,  polyamidoamine

    Enhancement strategies for transdermal drug delivery systems: current trends and applications

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