53 research outputs found
Modeling of multiple filamentation of terawatt laser pulses on a hundred-meter air path
The results of numerical simulation of multiple filamentation of terawatt femtosecond pulse Ti:Sapphire laser performed on the experimental data obtained in the airway of a length of 106 m when changing the initial spatial focusing and laser power
ΠΠ΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ
The paper presents data on the pathogenesis of systemic lupus erythematosus (SLE), and depicts various molecular mechanisms for the development of SLE and lupus-like syndromes. It describes groups of diseases, such as apoptotic defects; NETosis; interferonopathies; complement deficiency; autotolerance disorders associated with mutations in the RAG1/RAG2 genes; hereditary metabolic diseases (prolidase deficiency, deficiency of adenosine deaminase 2; lysinuric protein intolerance; and Ξ±-mannosidase deficiency). The table summarizes clinical data on most of the known lupus-like syndromes and their molecular mechanisms.The pathogenesis of many forms of monogenic lupus-like diseases is being studied. The main sign suggesting in favor of the possible monogenic disease in a patient with SLE is its onset in infancy, especially in males. Attention should be also paid to a compromised family history, including to the marriage between close relatives, the resistance of disease to standard therapy, as well as atypical symptoms.Β Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠΈ (Π‘ΠΠ), ΠΎΠΏΠΈΡΠ°Π½Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π‘ΠΠ ΠΈ Π²ΠΎΠ»ΡΠ°Π½ΠΎΡΠ½ΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ
ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠ². ΠΠΏΠΈΡΠ°Π½Ρ ΡΠ°ΠΊΠΈΠ΅ Π³ΡΡΠΏΠΏΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΊΠ°ΠΊ Π΄Π΅ΡΠ΅ΠΊΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°, Π½Π΅ΡΠΎΠ·, ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠΏΠ°ΡΠΈΠΈ, Π΄Π΅ΡΠΈΡΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΌΠ΅Π½ΡΠ°, Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ Π°ΡΡΠΎΡΠΎΠ»Π΅ΡΠ°Π½ΡΠ½ΠΎΡΡΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ Π² Π³Π΅Π½Π°Ρ
RAG1/RAG2, Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΎΠ±ΠΌΠ΅Π½Π° (Π΄Π΅ΡΠΈΡΠΈΡ ΠΏΡΠΎΠ»ΠΈΠ΄Π°Π·Ρ, Π΄Π΅ΡΠΈΡΠΈΡ Π°Π΄Π΅Π½ΠΎΠ·ΠΈΠ½Π΄Π΅Π·Π°ΠΌΠΈΠ½Π°Π·Ρ 2-Π³ΠΎ ΡΠΈΠΏΠ°, Π»ΠΈΠ·ΠΈΠ½ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π½Π΅ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ Π±Π΅Π»ΠΊΠ°, Π΄Π΅ΡΠΈΡΠΈΡ Ξ±-ΠΌΠ°Π½Π½ΠΎΠ·ΠΈΠ΄Π°Π·Ρ). Π Π²ΠΈΠ΄Π΅ ΡΠ°Π±Π»ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
Π²ΠΎΠ»ΡΠ°Π½ΠΎΡΠ½ΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ
ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠ² ΠΈ ΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
.ΠΠ°ΡΠΎΠ³Π΅Π½Π΅Π· ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠΎΡΠΌ ΠΌΠΎΠ½ΠΎΠ³Π΅Π½Π½ΡΡ
Π²ΠΎΠ»ΡΠ°Π½ΠΎΡΠ½ΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π½Π°Ρ
ΠΎΠ΄ΠΈΡΡΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠΌ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΠΌ Π² ΠΏΠΎΠ»ΡΠ·Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π‘ΠΠ, ΡΠ²Π»ΡΠ΅ΡΡΡ Π΅Π³ΠΎ Π½Π°ΡΠ°Π»ΠΎ Π² ΡΠ°Π½Π½Π΅ΠΌ Π΄Π΅ΡΡΠΊΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΌΡΠΆΡΠΊΠΈΠΌ ΠΏΠΎΠ»ΠΎΠΌ. Π’Π°ΠΊΠΆΠ΅ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΎΠ±ΡΠ°ΡΠ°ΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΎΡΡΠ³ΠΎΡΠ΅Π½Π½ΡΠΉ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΡΠΉ Π°Π½Π°ΠΌΠ½Π΅Π·, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π° ΡΠ°ΠΊΡ Π±Π»ΠΈΠ·ΠΊΠΎΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π±ΡΠ°ΠΊΠ°, ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΊ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ Π½Π΅ΡΠΈΠΏΠΈΡΠ½ΡΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΠΊΡ.
Filamentation of focused and collimated laser beams in liquids
Experimental results of investigations into the transformation of the spectral and spatial characteristics of femtosecond collimated and focused Ti:Sapphire-laser beams with wavelengths of 800 and 400 nm upon filamentation in continuous liquid media are presented. It is shown that broadening of the laser pulse spectrum due to phase self-modulation in the medium with a cubic nonlinearity depends on the pulse power and beam diameter. Dependences of the number of filaments, width of laser radiation spectrum, nonlinear focusing distance, and diameter of the filamentation region on the laser pulse power are measured. The existence of a relative power interval in which the explosive growth of the number of filaments occurs, is established. Β© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only
2020 Clinical guidelines for Atrial fibrillation and atrial flutter
Russian Society of Cardiology (RSC).With the participation of Russian Scientific Society of Clinical Electrophysiology, Arrhythmology and Cardiac Pacing, Russian Association of Cardiovascular Surgeons.Approved by the Scientific and Practical Council of the Russian Ministry of Health
Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2\u2009cm; P\u20091.5\u2009cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs <2.8\u2009cm vs 652.8\u2009cm (94% vs 85% by 10 years; P\u2009=\u20090.020; 80% vs 50% at 10 years; P\u2009=\u20090.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8\u2009cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs
Ventricular arrhythmias. Ventricular tachycardias and sudden cardiac death. 2020 Clinical guidelines
Russian Society of Cardiology (RSC).With the participation of Russian Scientific Society of Clinical Electrophysiology, Arrhythmology and Cardiac Pacing, Russian Association of Pediatric Cardiologists, Society for Holter Monitoring and Noninvasive Electrocardiology.Approved by the Scientific and Practical Council of the Russian Ministry of Health
- β¦