28 research outputs found
Histaminergic system in brain disorders: lessons from the translational approach and future perspectives
Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer’s disease, schizophrenia, sleep disorders, drug dependence, and Parkinson’s disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans
Alteração de biomarcadores de lesão miocárdica em atletas após a Maratona Internacional de São Paulo
Utilidad de la distancia recorrida en una prueba de ejercicio incremental como predictor de morbilidad postoperatoria en la resección del cáncer de pulmón. Abordaje multidisciplinar: cirugía torácica – anestesiología
[ES] El cáncer de pulmón no microcítico es hoy en día la primera causa de mortalidad por enfermedad neoplásica en hombres.[EN] The non-small cell lung cancer is now the leading cause of death from malignant disease in men