Sensory integration intervention and the development of the premature infant: A controlled trial

Background. Premature infants are at risk of sensory processing difficulties and developmental delays due to an immature central nervous system and possible episodes of medical instability, discomfort, pain and stress during the first weeks or months after birth.Objective. To investigate the effect of Ayres Sensory Integration (ASI) on the development of premature infants in the first 12 months of life.Methods. A pre-/post-test experimental design was used to randomly divide 24 premature infants from a low socioeconomic setting in Bloemfontein, South Africa, into experimental and control groups after being matched by corrected age and gender. Developmental status was determined with the Bayley III Scales of Infant and Toddler Development, the Test of Sensory Functions in Infants and the Infant/ Toddler Sensory Profile. The experimental group received 10 weeks of ASI intervention.Results. ASI intervention had a positive effect on the sensory processing and development of premature infants, especially in terms of cognitive, language and motor development.Conclusions. ASI intervention at an early age enhances the developmental progress of premature infants

Strengthening the UN to Confront Collective Challenges. Policy paper for G20

A sustainable, efficient, and thriving modern global multilateral system needs a functional and proactive the United Nations (UN). The UN represents the hopes and aspirations of millions of people around the world for a better life. Consequently, it is imperative that the UN is fully capable of setting and executing the required collective global multilateral agenda. This objective has not yet been fully achieved, and numerous bodies and critics have been calling for a fundamental reform of the UN for a number of years. This policy paper is the result of expert consultations focused on identifying necessary, near-term reforms for the United Nations (UN) which are both feasible and capable of obtaining wide support

Effective Health Care and Global Pandemic Preparedness. Policy paper for G20

Well-functioning health systems are a pre-requisite for achieving Sustainable Development Goal 3 (SDG 3) Good Health and Wellbeing. The COVID-19 pandemic demonstrated that the global health system should become more effective and equitable. The World Health Organization (WHO) serves as a vital resource for countries to enhance their national public health systems, and as a catalyst and enabler of multilateral cooperation for addressing global health-related threats. This policy paper proposes several key recommendations that, in the view of an expert panel, could be implemented in the near term to further strengthen and empower the WHO

Strengthening WTO and the Global Trade System for Sustainable Development. Policy paper for G20

The dynamics of the global trade system is a key influencer in the transition to a sustainable future for humanity. This policy paper emerged from a consultation process with a panel of renowned experts. They focused on how the World Trade Organization (WTO) could be strengthened to provide a global trade system supportive of the sustainability agenda. It is recognized that the WTO was conceived in a different world from the one we live in today, geopolitically and ideologically. This policy paper raises several key recommendations that, in the view of the expert panel, could be implemented in the short term and would achieve a substantial impact to expand the mandate and influence of the WTO, within the broader context of improving global governance to address global societal challenges

Making Transformation Happen: Climate Finance. Policy paper for G20

Climate finance is a key instrument to enable the global response to climate change. Special financial arrangements are required to scale up investment in mitigation alongside adaptation to facilitate the transformation of global societies to a more sustainable, resilient, and equitable future. In 2022, at UNFCCC COP27 the third pillar, a loss and damage fund, was pledged to address the impacts of climate change that cannot be reversed through mitigation or adaptation measures. However, until now, both the quality and quantity of climate finance pledges remains inadequate to fund the required interventions. This policy paper provides recommendations from a consultation process with a panel of experts, who addressed the challenges and opportunities associated with finding adequate climate finance in pursuit of climate progress and sustainable development

Sensory integration intervention and the development of the premature infant: A controlled trial

Background. Premature infants are at risk of sensory processing difficulties and developmental delays due to an immature central nervous system and possible episodes of medical instability, discomfort, pain and stress during the first weeks or months after birth.Objective. To investigate the effect of Ayres Sensory Integration (ASI) on the development of premature infants in the first 12 months of life.Methods. A pre-/post-test experimental design was used to randomly divide 24 premature infants from a low socioeconomic setting in Bloemfontein, South Africa, into experimental and control groups after being matched by corrected age and gender. Developmental status was determined with the Bayley III Scales of Infant and Toddler Development, the Test of Sensory Functions in Infants and the Infant/Toddler Sensory Profile. The experimental group received 10 weeks of ASI intervention.Results. ASI intervention had a positive effect on the sensory processing and development of premature infants, especially in terms of cognitive, language and motor development.Conclusions. ASI intervention at an early age enhances the developmental progress of premature infants.

Progression of coronary artery calcification in conventional hemodialysis, nocturnal hemodialysis, and kidney transplantation

Introduction Cardiovascular disease is the leading cause of death in end-stage renal disease (ESRD) and is strongly associated with vascular calcification. An important driver of vascular calcification is high phosphate levels, but these become lower when patients initiate nocturnal hemodialysis or receive a kidney transplant. However, it is unknown whether nocturnal hemodialysis or kidney transplantation mitigate vascular calcification. Therefore, we compared progression of coronary artery calcification (CAC) between patients treated with conventional hemodialysis, nocturnal hemodialysis, and kidney transplant recipients. Methods We measured CAC annually up to 3 years in 114 patients with ESRD that were transplantation candidates: 32 that continued conventional hemodialysis, 34 that initiated nocturnal hemodialysis (>= 4x 8 hours/week), and 48 that received a kidney transplant. We compared CAC progression between groups as the difference in square root transformed volume scores per year (Delta CAC SQRV) using linear mixed models. Reference category was conventional hemodialysis. Results The mean age of the study population was 53 +/- 13 years, 75 (66%) were male, and median dialysis duration was 28 (IQR 12-56) months. Median CAC score at enrollment was 171 (IQR 10-647), which did not differ significantly between treatment groups (P = 0.83). Compared to conventional hemodialysis, CAC progression was non-significantly different in nocturnal hemodialysis -0.10 (95% CI -0.77 to 0.57) and kidney transplantation -0.33 (95% CI -0.96 to 0.29) in adjusted models. Conclusions Nocturnal hemodialysis and kidney transplantation are not associated with significantly less CAC progression compared to conventional hemodialysis during up to 3 years follow-up. Further studies are needed to confirm these findings, to determine which type of calcification is measured with CAC in end-stage renal disease, and whether that reflects cardiovascular risk

Factors determining social participation in the first year after kidney transplantation: a prospective study

BACKGROUND: This study describes changes in social participation in the first year after kidney transplantation and examines the influence of clinical factors, health status, transplantation-related symptoms, and psychological characteristics on change in social participation. METHODS: A prospective study was performed on a cohort of primary kidney transplant recipients, transplanted between March 2002 and March 2003. Data on participation in obligatory activities (i.e., employment, education, household tasks) and leisure activities (i.e., volunteer work, assisting others, sports, clubs/associations, recreation, socializing, going out) were collected by in-home interviews (n=61) at 3 months (T1) and 1 year posttransplantation (T2). Analysis of covariance was performed. RESULTS: Data showed an increase in participation in obligatory activities and diversity of leisure participation between T1 and T2, although pre-end-stage renal disease level was not regained and differed from the general population. On T1, the majority of employed recipients were on sick leave, but returned to work on T2. Employment rate remained stable. An increase in obligatory participation was predicted by clinical factors (i.e., peritoneal dialysis, initial hospitalization), whereas change in leisure participation was related to serum albumin and cognitive capacity. No effects were found for type of donation, comorbidity, and renal function. CONCLUSIONS: We found that mainly clinical factors were associated with an increase in participation in society. Although health-status related factors and the psychological attribute self-efficacy may be related to recovery of social participation, their effect was outweighed by the strength of clinical predictors in multivariate analysis