27 research outputs found

    Africans Who Arrive in the United States before 20 Years of Age Maintain Both Cardiometabolic Health and Cultural Identity: Insight from the Africans in America Study

    Full text link
    The overall consensus is that foreign-born adults who come to America age \u3c 20 y achieve economic success but develop adverse behaviors (smoking and drinking) that lead to worse cardiometabolic health than immigrants who arrive age ≄ 20 y. Whether age of immigration affects the health of African-born Blacks living in America is unknown. Our goals were to examine cultural identity, behavior, and socioeconomic factors and determine if differences exist in the cardiometabolic health of Africans who immigrated to America before and after age 20 y. Of the 482 enrollees (age: 38 ± 1 (mean ± SE), range: 20–65 y) in the Africans in America cohort, 23% (111/482) arrived age \u3c 20 y, and 77% (371/482) arrived age ≄ 20 y. Independent of francophone status or African region of origin, Africans who immigrated age \u3c 20 y had similar or better cardiometabolic health than Africans who immigrated age ≄ 20 y. The majority of Africans who immigrated age \u3c 20 y identified as African, had African-born spouses, exercised, did not adopt adverse health behaviors, and actualized early life migration advantages, such as an American university education. Due to maintenance of cultural identity and actualization of opportunities in America, cardiometabolic health may be protected in Africans who immigrate before age 20. In short, immigrant health research must be cognizant of the diversity within the foreign-born community and age of immigration

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Get PDF

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

    Get PDF
    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

    Basin-scale estimates of greenhouse gas emissions from the Mara River, Kenya: Importance of discharge, stream size, and land use/land cover

    No full text
    Greenhouse gas fluxes (CO2, CH4, and N2O) from African streams and rivers are under-represented in global datasets, resulting in uncertainties in their contributions to regional and global budgets. We conducted year-long sampling of 59 sites in a nested-catchment design in the Mara River, Kenya in which fluxes were quantified and their underlying controls assessed. We estimated annual basin-scale greenhouse gas emissions from measured in-stream gas concentrations, modeled gas transfer velocities, and determined the sensitivity of up-scaling to discharge. Based on the total annual CO2-equivalent emissions calculated from global warming potentials (GWP), the Mara basin was a net greenhouse gas source (294 ± 35 Gg CO2 eq yr−1). Lower-order streams (1–3) contributed 81% of the total fluxes, and higher stream orders (4–8) contributed 19%. Cropland-draining streams also exhibited higher fluxes compared to forested streams. Seasonality in stream discharge affected stream widths (and stream area) and gas exchange rates, strongly influencing the basin-wide annual flux, which was 10 times higher during the high and medium discharge periods than the low discharge period. The basin-wide estimate was underestimated by up to 36% if discharge was ignored, and up to 37% for lower stream orders. Future research should therefore include seasonality in stream surface areas in upscaling procedures to better constrain basin-wide fluxes. Given that agricultural activities are a major factor increasing riverine greenhouse gas fluxes in the study region, increased conversion of forests and agricultural intensification has the possibility of increasing the contribution of the African continent to global greenhouse gas sources

    Africans Who Arrive in the United States before 20 Years of Age Maintain Both Cardiometabolic Health and Cultural Identity: Insight from the Africans in America Study

    No full text
    The overall consensus is that foreign-born adults who come to America age < 20 y achieve economic success but develop adverse behaviors (smoking and drinking) that lead to worse cardiometabolic health than immigrants who arrive age ≥ 20 y. Whether age of immigration affects the health of African-born Blacks living in America is unknown. Our goals were to examine cultural identity, behavior, and socioeconomic factors and determine if differences exist in the cardiometabolic health of Africans who immigrated to America before and after age 20 y. Of the 482 enrollees (age: 38 ± 1 (mean ± SE), range: 20–65 y) in the Africans in America cohort, 23% (111/482) arrived age < 20 y, and 77% (371/482) arrived age ≥ 20 y. Independent of francophone status or African region of origin, Africans who immigrated age < 20 y had similar or better cardiometabolic health than Africans who immigrated age ≥ 20 y. The majority of Africans who immigrated age < 20 y identified as African, had African-born spouses, exercised, did not adopt adverse health behaviors, and actualized early life migration advantages, such as an American university education. Due to maintenance of cultural identity and actualization of opportunities in America, cardiometabolic health may be protected in Africans who immigrate before age 20. In short, immigrant health research must be cognizant of the diversity within the foreign-born community and age of immigration

    Scoping review of qualitative studies investigating reproductive health knowledge, attitudes, and practices among men and women across Rwanda.

    No full text
    BackgroundResearch efforts in Rwanda to improve sexual and reproductive health and rights (SRHR) are increasing; however, comprehensive literature reviews on SRHR are limited. This scoping review examines individual and contextual factors shaping knowledge, attitudes, and practices in the domains of: 1) family planning, 2) abortion care, and 3) other SRHR in Rwanda. Recognizing that individual, community, and societal factors influence RH, this review is guided by Bronfenbrenner's Ecological Systems Theory.MethodsEligible studies were conducted in Rwanda, included males and/or females of any age, and were published within the past 20 years. Studies reporting views of only healthcare or other professionals were excluded.ResultsThirty-six studies were included. The majority addressed individual and contextual considerations. At the individual level, studies explored knowledge about SRHR problems while at the interpersonal level, the support and attitudes of men and community members for adolescent SRHR were investigated. In terms of healthcare organization, maternal health practices, increased access to family planning programs, and the need for sexually transmitted infection programs was explored. At the social and cultural level, researchers investigated beliefs and traditional gender roles. Regarding public health policy, studies mentioned promoting and increasing funding for SRHR and reducing gender inequities.ConclusionOur findings can inform SRHR research programs, public health campaigns, and policy advances in Rwanda

    SEARCH STRATEGIES | Scoping review of qualitative studies investigating reproductive health knowledge, attitudes, and practices among men and women across Rwanda

    No full text
    Scoping review search strategies.A search of the literature was conducted by a health sciences informationist (GKR) in March 2022. The eight databases searched were MEDLINE (via Ovid interface), EMBASE (via Embase.com), Scopus, CINAHL (via EBSCOhost), Web of Science Core Collection (via Thomson Reuters), Global Health (via CABI), PsycINFO (via EBSCOhost) and Women's Studies International (via EBSCOhost). Keyword and controlled vocabulary search terms were used to represent three main search concepts related to aspects of SRH: 1) family planning; 2) abortion care; and 3) sexual and reproductive health rights. Geographic search terms were used to focus the search retrieval on articles referencing Rwanda at the country level, by province, or by the capital city of Kigali. Lastly, a revised qualitative/mixed methods search filter was used in all eight database searches. Two unique qualitative/mixed methods search filters were revised for use in Ovid Medline to maximize retrieval of qualitative studies.http://deepblue.lib.umich.edu/bitstream/2027.42/175847/1/Rwanda SRHR _ Scoping Review of Qualitative Studies_ ALL SEARCH STRATEGIES _ March 2022.pdf-1Description of Rwanda SRHR _ Scoping Review of Qualitative Studies_ ALL SEARCH STRATEGIES _ March 2022.pdf : Search strategiesSEL

    High Temperature Fire Experiment for TET and LANDSAT 8 in Test Site DEMMIN (Germany)

    No full text
    In 2012, the German Aerospace Center (DLR) launched the small satellite TET-1 (Experimental Technology Carrier) as a test platform for new satellite technologies and as a carrier for the Multi-Spectral Camera System (MSC) with five spectral bands (Green, Red, Near Infrared, Middle Infrared, and Thermal Infrared). The MSC has been designed to provide quantitative parameters (e.g. fire radiative power, burned area) observing high-temperature events. The detection of such events provides information for operational support to fire brigades, to change detection of hotspots, to assess CO2 emissions of burning vegetation, and, finally, contributes to the monitoring programs that support climate models. In order to investigate the sensitivity and accuracy of the MSC system, a calibration and validation fire campaign was developed and executed, to derive characteristic signal changes of corresponding pixels in the MWIR and LWIR bands. The planning and execution of the validation campaign and the results are presented
    corecore