Validación de escalas y pruebas neuropsicológicas para enfermedades neurodegenerativas en una población colombiana

IP 1115-04-11941Incluye anexosPONENCIA(S) EN CONGRESO: Utility of a semantic cue recallmemorytest, shortened version for dementia;diagnosis in a Colombian population / A. Arboleda, D. A. Pineda,E. Lara,F. Lopera, E. Henao, D. C. Aguirre,;Baltimore Maryland, USA);C. Franco, Abraham Arana Chacon. - En: International Neuropsychological Society (32 : 2004 Feb. 4-7

Caracterización epidemiológica y virológica de la rinotraqueítis infecciosa bovina en Colombia

IP 1115-07-018-95epidemiologica y virologica de la rinotraquetis infecciosabovina en Colombia / Juan Carlos Zapata J...(et;al.) En: Caracterizacion epidemiologica y virologica de larinotraquetis:informe especial;ARTICULOS DE REVISTA : Espectro clinico y epidemioligico de larinotraqueitis infecciosa bovina /;J.J.Arboleda..(et al.) En : Revista Colombiana de CienciasPecuarias. Vol.9, no. 1y2 (1996) -- El herpesvirus;Bovino -1 : estructura,replicacion y latencia / J.D. Rodas..(etal.) En: Revista Colombiana de Ciencias;Pecuarias. Vol. 9, no. 1y2 (1996) -- Estandarizacion de latecnica de Elisa para rinotraqueitis infecciosa;bovina (RIB) y determinacin de la prevalencia de la infeccionenel hato blanco orejinegro (BON) de Antioquia;/ JD Rodas..(et al) En: Revista Colombiana de Ciencias Pecuarias. Vol. 9,no. 1y2 (1996) --Estandarizacion de;una prueba de Elisa para la deteccion de anticuerpos contra elherpesvirusBovino-1 (HBV-1) en suero lacteo /;J.D. Rodas..(et al.) En: Revista Colombiana de Ciencias Pecuarias. Vol. 9,no. 1y2 (1996) --Estandarizacin de;una tecnica de reaccion en cadena de la polimerasa (PCR) paraladetecciondel herpes virus bovino-1 (HVB-1);en semen / J.D. Rodas..(et al.) En: Revista Colombiana deCiencias Pecuarias. Vol. 9, no.1y2 (1996) --;Evaluacion del tratamiento de semen bovino con anticuerposespecificos contra la rinotraquetis infecciosa;bovina (RIB) : ensayos preliminares / J.D. Rodas..(et al.)En:Revista Colombiana de Ciencias Pecuarias. Vol.;9, no. 1y2 (1996) -- Encuesta virologica de herpesvirusbovino-1(HVB-1) enla Feria de Ganados de Medellin /;M. Restrepo..(et al.) En: Revista Colombiana de Ciencias Pecuarias. Vol. 9, no. 1y2 (1996) --Estandarizacion d;la tecnica ELISA en leche entera para la deteccion de anticuerpos contra el herpesvirus Bovino-1 (HVB-1) /;J.C. Palacio...(et al.) En: Revista Colombiana de CienciasPecuarias. Vol.10, no. 2 (1997) -- Caracterizacio

A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms

A randomized blinded clinical trial was performed in 53 patients bitten by Bothrops sp. and Porthidium sp. in Antioquia and Chocó, Colombia, in order to compare the efficacy and safety of two antivenoms made of whole IgG obtained by either ammonium sulphate (monovalent anti-B. atrox) or caprylic acid (polyvalent) fractionation. Additionally, antivenoms were compared by electrophoretic and chromatographic analyses and anticomplementary activity in vitro. With a protocol of 2, 4 and 6 antivenom vials for the treatment of mild, moderate and severe envenomings, respectively, both antivenoms were equally efficient to neutralize the most relevant signs of envenoming and to clear serum venom levels in patients from the first hour and later on. Three patients with severe envenoming and initially treated with less than six vials on admission had persistent or recurrent venom antigenemia within 12-48 h. Monovalent antivenom fractionated by ammonium sulphate precipitation had higher amounts of protein aggregates and nonimmunoglobulin proteins than polyvalent antivenom fractionated by caprylic acid precipitation. Both antivenoms presented anticomplementary activity in vitro, being higher in the monovalent product. In agreement, monovalent antivenom induced a significantly higher incidence of early antivenom reactions (52%) than polyvalent antivenom (25%).Universidad de Costa Rica/[741-89-057]/UCR/Costa RicaDirección Seccional de Salud de Antioquia///ColombiaDirección Seccional de Salud del Chocó///ColombiaUniversidad de Antioquia///ColombiaInstituto Colombiano para el Desarrollo de la Ciencia y la Tecnología Francisco José de Caldas//COLCIENCIAS/ColombiaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP

CADASIL: pathogenesis, clinical and radiological findings and treatment CADASIL: patogênese, achados clínicos e radiológicos e tratamento

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common genetic cause of ischemic strokes and a most important model for the study of subcortical vascular dementia. This unrelentlessly progressive disease affects many hundreds of families all over the world but is not well studied in Brazil. This manuscript reviews pathogenetic, clinical, radiological and therapeutic features of CADASIL. The causal mutations are now very well known, but the same can not be said about its intimate pathogenetic mechanisms. The variable clinical presentation should lead physicians to actively pursue the diagnosis in many settings and to more thouroughly investigate family history in first degree relatives. A rational approach to genetic testing is however needed. Treatment of CADASIL is still largely empiric. High-quality therapeutic studies involving medications and cognitive interventions are strongly needed in CADASIL.<br>CADASIL é a causa genética mais freqüente de infartos cerebrais e constitui modelo importante de estudo de demências vasculares subcorticais. De natureza inexoravelmente progressiva, afeta milhares de pessoas em todo o mundo. Sua importância é pouco reconhecida entre nós, o que nos levou à presente revisão dos principais aspectos patogenéticos, clínicos, neuroradiológicos e terapêuticos da doença. As mutações causais são hoje bem conhecidas, mas os mecanismos patogenéticos íntimos ainda permanecem misteriosos. A apresentação clínica variável deve fazer com que os médicos considerem o diagnóstico em vários contextos clínicos e investiguem de forma mais extensa que o usual a história familial deparentes de primeiro grau. Além disso, uma abordagem racional é necessária para reduzir custos e aumentar a eficiência do diagnóstico genético. O tratamento atual de pacientes com CADASIL é basicamente empírico. Estudos clínicos sobre medicamentos e intervenções cognitivas de alto nível metodológico constituem uma necessidade urgente