61 research outputs found
Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to alzheimer’s disease
Shared and Disorder-Specific Event-Related Brain Oscillatory Markers of Attentional Dysfunction in ADHD and Bipolar Disorder.
Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) often present with overlapping symptoms and cognitive impairments, such as increased fluctuations in attentional performance measured by increased reaction-time variability (RTV). We previously provided initial evidence of shared and distinct event-related potential (ERP) impairments in ADHD and BD in a direct electrophysiological comparison, but no study to date has compared neural mechanisms underlying attentional impairments with finer-grained brain oscillatory markers. Here, we aimed to compare the neural underpinnings of impaired attentional processes in ADHD and BD, by examining event-related brain oscillations during a reaction-time task under slow-unrewarded baseline and fast-incentive conditions. We measured cognitive performance, ERPs and brain-oscillatory modulations of power and phase variability in 20 women with ADHD, 20 women with BD (currently euthymic) and 20 control women. Compared to controls, both ADHD and BD groups showed increased RTV in the baseline condition and increased RTV, theta phase variability and lower contingent negative variation in the fast-incentive condition. Unlike controls, neither clinical group showed an improvement from the slow-unrewarded baseline to the fast-incentive condition in attentional P3 amplitude or alpha power suppression. Most impairments did not differ between the disorders, as only an adjustment in beta suppression between conditions (lower in the ADHD group) distinguished between the clinical groups. These findings suggest shared impairments in women with ADHD and BD in cognitive and neural variability, preparatory activity and inability to adjust attention allocation and activation. These overlapping impairments may represent shared neurobiological mechanisms of attentional dysfunction in ADHD and BD, and potentially underlie common symptoms in both disorders.We thank all who made this research possible:
The National Adult ADHD Clinic at the South London and Maudsley
Hospital, Dr Helen Costello, Prof Sophia Frangou, Prof Anne Farmer,
Jessica Deadman, Hannah Collyer, Sarah-Jane Gregori, and all participants
who contributed their time to the study. Dr Giorgia Michelini
was supported by a 1+3 PhD studentship awarded by the MRC Social,
Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,
Psychology and Neuroscience, King’s College London (G9817803).
This project was supported by an Economic and Social Research Council
studentship to Dr Viryanaga Kitsune (ES/100971X/1). Dr Giorgia
Michelini and Prof Philip Asherson are supported by generous grants
from the National Institute for Health Research Biomedical Research
Centre for Mental Health at King’s College London, Institute of Psychiatry,
Psychology and Neuroscience and South London and Maudsley
National Health Service (NHS) Foundation Trust. The funders had
no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; preparation, review, or
approval of the manuscript; and decision to submit the manuscript for
publication
Influence of moisture content on elastic constants of Scots pine wood subjected to compression
Event-related delta oscillatory responses of Alzheimer patients
Background and purpose: Alzheimer type of dementia (AD) is the most common neuropsychiatric morbidity in elderly individuals. Event-related oscillations (ERO) provide an useful tool for detecting subtle abnormalities of cognitive processes with high temporal resolution. Methods: In the present report, event-related oscillations of patients with AD were analyzed by using a visual oddball paradigm. A total of 22 mild probable AD subjects according to NINCDS-ADRDA criteria and 20 age-, gender-, and education-matched healthy control subjects were compared. AD group consisted from 11 untreated patients and 11 patients treated with cholinesterase inhibitor. Oscillatory responses were recorded from 13 scalp electrodes. Results: Significant differences in delta frequency range were seen between the groups by using repeated measures of ANOVA analysis [F(9.120) = 2.228; P = 0.022]. Post-hoc analyses using Wilcoxon test showed that at mid- and left central regions, (Cz, C3) peak amplitudes of delta responses of healthy subjects were significantly higher than either group. Also cholinesterase inhibitors did not have effect on delta oscillatory responses. Conclusions: Our findings imply that the delta oscillatory responses at central locations are highly instable in mild probable AD patients regardless of treatment when compared to the healthy aged controls. This study supports the importance of oscillatory event-related potentials for investigating AD brain dynamics
Long-range evoked gamma coherence in acute mania before and after treatment: a sign for disturbed neural network connectivity
Phase-locking of frontal theta oscillations in Alzheimer's disease and their modulation by cholinesterase inhibitors
Classification of Parkinson's disease with dementia using phase locking factor of event-related oscillations to visual and auditory stimuli
Objective. In the last decades, machine learning approaches have been widely used to distinguish Parkinson's disease (PD) and many other neuropsychiatric diseases. They also speed up the clinicians and facilitate decision-making for several conditions with similar clinical symptoms. The current study attempts to detect PD with dementia (PDD) by event-related oscillations (EROs) during cognitive processing in two modalities, i.e. auditory and visual. Approach. The study was conducted to discriminate PDD from healthy controls (HC) using event-related phase-locking factors in slow frequency ranges (delta and theta) during visual and auditory cognitive tasks. Seventeen PDD and nineteen HC were included in the study, and linear discriminant analysis was used as a classifier. During classification analysis, multiple settings were implemented by using different sets of channels (overall, fronto-central and temporo-parieto-occipital (TPO) region), frequency bands (delta-theta combined, delta, theta, and low theta), and time of interests (0.1-0.7 s, 0.1-0.5 s and 0.1-0.3 s for delta, delta-theta combined; 0.1-0.4 s for theta and low theta) for spatial-spectral-temporal searchlight procedure. Main results. The classification performance results of the current study revealed that if visual stimuli are applied to PDD, the delta and theta phase-locking factor over fronto-central region have a remarkable contribution to detecting the disease, whereas if auditory stimuli are applied, the phase-locking factor in low theta over TPO and in a wider range of frequency (1-7 Hz) over the fronto-central region classify HC and PDD with better performances. Significance. These findings show that the delta and theta phase-locking factor of EROs during visual and auditory stimuli has valuable contributions to detecting PDD
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