11 research outputs found
N-Methylimidazole Promotes The Reaction Of Homophthalic Anhydride With Imines
Get PDFThe addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationalizes the role of NMI is proposed, and a gram-scale procedure for the synthesis and resolution of 10 is also described
Nonenzymatic Dynamic Kinetic Resolution of Secondary Alcohols via Enantioselective Acylation: Synthetic and Mechanistic Studies
No full textWidely Useful DMAP-Catalyzed Esterification under Auxiliary Base- and Solvent-Free Conditions
No full textRecent Advances in the use of Immobilized Lipases Directed Toward the Asymmetric Syntheses of Complex Molecules
No full textDrug Delivery Systems Based on Trimethyl Lock Lactonization: Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds
No full textA Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol)
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