8,038 research outputs found
The origin of the Acheulean: the 1.7 million-year-old site of FLK West, Olduvai Gorge (Tanzania)
The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the
emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with
standardized forms, implying more advance forethought and planning by hominins than those required
by the precedent Oldowan technology. The earliest known evidence of this technology dates back to
c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack fauna.
The functionality of these earliest Acheulean assemblages remains unknown. Here we present the
discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides
evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in
which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and
elaborate large-cutting tools (LCT) and handaxes co-exist at FLK West, showing that complex cognition
was present from the earliest stages of the Acheulean. Here we provide a detailed technological study
and evidence of the use of these tools on the butchery and consumption of fauna, probably by early
Homo erectus sensu lato
Increased adiposity appraised with cun-bae is highly predictive of incident hypertension. The sun project
Overweight and obesity are growing worldwide and strongly associated with hypertension. The Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index is proposed as an optimal indicator of body fatness. We aimed to investigate the association of body fat as captured by the CUN-BAE index with incident hypertension in a Mediterranean population. We assessed 15,950 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (63.7% women) initially free of hypertension. Participants completed follow-up questionnaires biennially. A validated 136-item food-frequency questionnaire was administered at baseline. We used Cox models adjusted for multiple confounders. Among 12.3 years of median follow-up (interquartile range: 8.3, 15.0 years), 2160 participants reported having received a diagnosis of hypertension. We observed a strong direct association between progressively higher the CUN-BAE index at baseline and incident hypertension during follow-up in multivariable-adjusted models for men and women, even after further adjustment for BMI ≥ 30 kg/m2, showing a significant association also in non-obese participants. For each 2-unit increase in the CUN-BAE index, hypertension risk increased by 27% and 29% in men and women, respectively. The results remained significant when considering longitudinal repeated measures of changes in body fat assessed with the CUN-BAE index among the different biennial follow-up questionnaires. Our results emphasize the importance of reducing and maintaining a low body fat to prevent hypertension
The morphology and clinical importance of the axillary arch
The axillary arch is the main variation of the axillary muscle. It was first described
by Ramsay in 1795. In its classical form, it arises from the latissimus
dorsi muscle and extends from this towards the pectoralis major, crossing the
base of the axilla and creating a close relationship with the elements of the
axillary neurovascular bundle. We describe the finding of 9 axillary arches, including
one case of a bilateral arrangement. We develop a searching and finding
technique for the axillary arch, essential for the safe and successful development
of surgical procedures in the axillary region. Knowledge of this muscle
variation and the possibility of finding it during axillary procedures is crucial for
lymph node staging and lymphadenectomy and is also important for differential
diagnosis in compressive pathologies of the axillary vessels and brachial
plexus
Milky Way Demographics with the VVV Survey II. Color Transformations and Near-Infrared Photometry for 136 Million Stars in the Southern Galactic Disk
The new multi-epoch near-infrared VVV survey (VISTA Variables in the Via
Lactea) is sampling 562 sq. deg of the Galactic bulge and adjacent regions of
the disk. Accurate astrometry established for the region surveyed allows the
VVV data to be merged with overlapping surveys (e.g., GLIMPSE, WISE, 2MASS,
etc.), thereby enabling the construction of longer baseline spectral energy
distributions for astronomical targets. However, in order to maximize use of
the VVV data, a set of transformation equations are required to place the VVV
JHKs photometry onto the 2MASS system. The impetus for this work is to develop
those transformations via a comparison of 2MASS targets in 152 VVV fields
sampling the Galactic disk. The transformation coefficients derived exhibit a
reliance on variables such as extinction. The transformed data were
subsequently employed to establish a mean reddening law of
E_{J-H}/E_{H-Ks}=2.13 +/- 0.04, which is the most precise determination to date
and merely emphasizes the pertinence of the VVV data for determining such
important parameters.Comment: 24 pages, 12 figures, published in A&
Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features
Understanding neural physiopathology requires advances in nanotechnology-based interfaces, engineered to monitor the functional state of mammalian nervous cells. Such interfaces typically contain nanometer-size features for stimulation and recording as in cell-non-invasive extracellular microelectrode arrays. In such devices, it turns crucial to understand specific interactions of neural cells with physicochemical features of electrodes, which could be designed to optimize performance. Herein, versatile flexible nanostructured electrodes covered by arrays of metallic nanowires are fabricated and used to investigate the role of chemical composition and nanotopography on rat brain cells in vitro. By using Au and Ni as exemplary materials, nanostructure and chemical composition are demonstrated to play major roles in the interaction of neural cells with electrodes. Nanostructured devices are interfaced to rat embryonic cortical cells and postnatal hippocampal neurons forming synaptic circuits. It is shown that Au-based electrodes behave similarly to controls. Contrarily, Ni-based nanostructured electrodes increase cell survival, boost neuronal differentiation, and reduce glial cells with respect to flat counterparts. Nonetheless, Au-based electrodes perform superiorly compared to Ni-based ones. Under electrical stimulation, Au-based nanostructured substrates evoke intracellular calcium dynamics compatible with neural networks activation. These studies highlight the opportunity for these electrodes to excite a silent neural network by direct neuronal membranes depolarization
Density functional formalism in the canonical ensemble
Density functional theory, when applied to systems with , is based
on the grand canonical extension of the Hohenberg-Kohn-Sham theorem due to
Mermin (HKSM theorem). While a straightforward canonical ensemble
generalization fails, work in nanopore systems could certainly benefit from
such extension. We show that, if the asymptotic behaviour of the canonical
distribution functions is taken into account, the HKSM theorem can be extended
to the canonical ensemble. We generate -modified correlation and
distribution functions hierarchies and prove that, if they are employed, either
a modified external field or the density profiles can be indistinctly used as
independent variables. We also write down the % -modified free energy
functional and prove that its minimum is reached when the equilibrium values of
the new hierarchy are used. This completes the extension of the HKSM theorem.Comment: revtex, to be submitted to Phys. Rev. Let
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