Blinded by Anger or Feeling the Love: How Emotions Influence Advice Taking

Across 2 experiments, the authors demonstrate that emotional states influence how receptive people are to advice. The focus of these experiments is on incidental emotions, emotions triggered by a prior experience that is irrelevant to the current situation. The authors demonstrate that people who feel incidental gratitude are more trusting and more receptive to advice than are people in a neutral emotional state, and people in a neutral state are more trusting and more receptive to advice than are people who feel incidental anger. In these experiments, greater receptivity to advice increased judgment accuracy. People who felt incidental gratitude were more accurate than were people in a neutral state, and people in a neutral state were more accurate than were people who felt incidental anger. The results offer insight into how people use advice, and the authors identify conditions under which leaders, policy makers, and advisors may be particularly influential

The e+ e- -> P1 P2 gamma processes close to the Phi peak: toward a model-independent analysis

We discuss the general decomposition and possible general parameterizations of the processes $e^+ e^- \to \gamma^* \to P_1 P_2 \gamma$, where $P_1 P_2=\pi^0 \pi^0$, $\pi^0\eta$, or $\pi^+\pi^-$, for $\sqrt{s}\approx M_\Phi$. Particular attention is devoted to the amplitude where the two pseudoscalar mesons are in a $J^{CP}= 0^{++}$ state, where we propose a general parameterization which should help to shed light on the nature of light scalar mesons.Comment: 12 pages, Late

Seismic reliability analysis of isolated deck bridges using friction pendulum devices

In this study, the seismic reliability of multi-span continuous deck bridges equipped with isolation friction pendulum (FP) devices is investigated. The relevant aleatory uncertainties associated to the sliding friction coefficient of the FP isolators and to the seismic inputs are considered. A six-degree-of-freedom model is established to reproduce the elastic behavior of the reinforced concrete (RC) pier, the stiff response of the deck supported by the isolation devices and the non-linear response of the FPS bearings which depends on the sliding velocity. Moreover, the RC abutment is assumed as infinitely rigid. For what concerns the seismic inputs, a group of natural seismic records having various characteristics is adopted and properly scaled to increasing levels of intensity. The random variability of the friction coefficient is modelled by suitable probabilistic distribution. Then, considering several bridges and isolator configurations, the fragility curves of the RC pier and of the isolator devices (FP) are determined. Finally, in agreement with the hazard curve of the specific site, the convolution integral is adopted to determine the seismic reliability curves in the performance domain

Approaches to estimate global safety factors for reliability assessment of RC structures using non-linear numerical analyses

The study is focused on the comparison and discussion of different approaches within the use of the global resistance method (GRM) for safety assessment of reinforced concrete (RC) systems using non-linear numerical analyses (NLNAs). With this purpose, a benchmark dataset, comprising 56 experimental results obtained from tests on 40 RC columns with variable slenderness and 16 non-slender RC elements including walls, deep beams and shear walls, is considered. The NLN models for all the 56 members adopt solution strategies able to optimize the agreement between numerical predictions and experimental outcomes. Then, probabilistic hypotheses have been defined regarding both aleatory (i.e., materials and geometry) and epistemic uncertainties (i.e., model) associated with all the 56 RC members. These assumptions form the basis for developing a comprehensive set of probabilistic analyses of the global structural resistance for each RC member. The results of these probabilistic analyses offer valuable insights into the impact of the different sources of uncertainties on the global structural response. In detail, three distinct approaches for estimating the global safety factors within the GRM are outlined and compared. The purpose is to address the effectiveness of the different approaches for the reliability evaluation of RC members within the GRM together with the relevance of both aleatory and epistemic uncertainties. Ultimately, recommendations are provided regarding the adoption of the GRM in the upcoming generation of design codes

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival.

BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type. Nomograms are useful tools for individualized estimation of survival. This study aimed to develop and independently validate a nomogram for IDH-wild-type patients with newly diagnosed GBM.MethodsData were obtained from newly diagnosed GBM patients from the Ohio Brain Tumor Study (OBTS) and the University of California San Francisco (UCSF) for diagnosis years 2007-2017 with the following variables: age at diagnosis, sex, extent of resection, concurrent radiation/temozolomide (TMZ) status, Karnofsky Performance Status (KPS), O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and IDH mutation status. Survival was assessed using Cox proportional hazards regression, random survival forests, and recursive partitioning analysis, with adjustment for known prognostic factors. The models were developed using the OBTS data and independently validated using the UCSF data. Models were internally validated using 10-fold cross-validation and externally validated by plotting calibration curves.ResultsA final nomogram was validated for IDH-wild-type newly diagnosed GBM. Factors that increased the probability of survival included younger age at diagnosis, female sex, having gross total resection, having concurrent radiation/TMZ, having a high KPS, and having MGMT methylation.ConclusionsA nomogram that calculates individualized survival probabilities for IDH-wild-type patients with newly diagnosed GBM could be useful to physicians for counseling patients regarding treatment decisions and optimizing therapeutic approaches. Free software for implementing this nomogram is provided: https://gcioffi.shinyapps.io/Nomogram_For_IDH_Wildtype_GBM_H_Gittleman/

Anxiety, Advice, and the Ability to Discern: Feeling Anxious Motivates Individuals to Seek and Use Advice

Across eight experiments, we describe the influence of anxiety on advice seeking and advice taking. We find that anxious individuals are more likely to seek and rely on advice than are those in a neutral emotional state (Experiment 1), but this pattern of results does not generalize to other negatively-valenced emotions (Experiment 2). The relationships between anxiety and advice seeking and anxiety and advice taking are mediated by self-confidence; anxiety lowers self-confidence, which increases advice seeking and reliance upon advice (Experiment 3). Though anxiety also impairs information processing, impaired information processing does not mediate the relationship between anxiety and advice taking (Experiment 4). Finally, we find that anxious individuals fail to discriminate between good and bad advice (Experiment 5a-c), and between advice from advisors with and without a conflict of interest (Experiment 6)

The Cheater’s High: The Unexpected Affective Benefits of Unethical Behavior

Many theories of moral behavior assume that unethical behavior triggers negative affect. In this article, we challenge this assumption and demonstrate that unethical behavior can trigger positive affect, which we term a “cheater’s high.” Across 6 studies, we find that even though individuals predict they will feel guilty and have increased levels of negative affect after engaging in unethical behavior (Studies 1a and 1b), individuals who cheat on different problem-solving tasks consistently experience more positive affect than those who do not (Studies 2–5). We find that this heightened positive affect does not depend on self-selection (Studies 3 and 4), and it is not due to the accrual of undeserved financial rewards (Study 4). Cheating is associated with feelings of self-satisfaction, and the boost in positive affect from cheating persists even when prospects for self-deception about unethical behavior are reduced (Study 5). Our results have important implications for models of ethical decision making, moral behavior, and self-regulatory theory

Prognostic significance of serine-phosphorylated STAT3 expression in pT1-T2 oral tongue carcinoma

Objectives. Phosphorylated (activated) STAT3 (pSTAT3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion, angiogenesis, and the evasion of immune surveillance. This study aimed mainly to investigate the potential prognostic role of pSTAT3 expression in oral tongue squamous cell carcinoma (SCC). Methods. Phospho-ser727 STAT3 immunolabeling was correlated with prognostic parameters in 34 consecutive cases of pT1\u2013T2 tongue SCCs undergoing primary surgery. Computer-based image analysis was used for the immunohistochemical reactions analysis. Results. Statistical analysis showed a difference in disease-free survival (DFS) when patients were stratified by pN status (P=0.031). Most tumors had variable degrees (mean\ub1SD, 80.7%\ub123.8%) of intense nuclear immunoreaction to pSTAT3. Our findings rule out any significant association of serine-phosphorylated nuclear STAT3 expression with tumor stage, grade, lymph node metastasis, recurrence rate, or DFS. Conclusion. In spite of these results, it is worth further investigating the role of pSTAT3 (serine-and tyrosine-pSTAT3) in oral tongue SCC in larger series because preclinical models are increasingly showing that several anticancer strategies would benefit from STAT3 phosphorylation inhibition

Privacy and ethical challenges of the Amelogenin sex test in forensic paternity/kinship analysis: Insights from a 13-year case history

The Amelogenin sex test included in forensic DNA typing kits has the potential to identify congenital conditions such as differences/disorders of sex development (DSD). It can also reveal mismatches between genotypic sex and gender marker in identity documents of transgender persons who obtained legal gender recognition. In a 13-year case history of paternity/kinship tests, involving n = 962 females and n = 1001 males, two mismatches between Amelogenin sex test (male) and gender marker (female), and three cases of chromosomal DSD (Klinefelter syndrome) were observed. The concrete risk of observing Amelogenin anomalies, their potential causes, and the context in which they occur (forensic, i.e. non-medical) mean that laboratory operators are called to strike a complex balance between privacy interests and individual health rights when providing preliminary information and reporting Amelogenin incidental findings. This case history argues for the need of a more responsible approach towards the Amelogenin sex test in the forensic community