The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

Oriented cell behaviors likely have a more important role in limb bud elongation during development than previously suggested by the “growth-based morphogenesis” hypothesis

Possible role of defibrotide in endothelial cell protection

Defibrotide is a single-stranded DNA fraction obtained from mammalian lung and is able to increase prostacyclin production by endothelial cells. It has profibrinolytic and antithrombotic properties, and we have successfully used it as an anti-ischaemic drug in many in-vivo experimental models. In fact, we showed that defibrotide treatment significantly protected rat heart, kidney and liver from ischaemia and postischaemic reperfusion injury. In rats treated with defibrotide, the functionality and metabolic activity of ischaemic organs were significantly protected from impairment as compared to controls treated only with the vehicle of the drug. In the present work we evaluated all our results, together with those of others, in order to hypothesize the mechanism of action of the drug. We postulated that the prominent function of defibrotide is to inhibit platelet and leukocyte adhesion to endothelial cells: this may depend on reduced cell activation possibly following drug interaction with adenosine receptors. Defibrotide could also favour endothelial-cell function through binding with haemoglobin: such binding permits oxygen release and preservation of endothelium-derived relaxing factor. Moreover, prostacyclin production by endothelial cells is responsible for many drug activities and also limits superoxide radical generation

Aplikasi Berbasis Dekstop untuk Persediaan Bahan Baku Produksi Menggunakan Model Waterfall (Study Kasus: PT. Seyon Indonesia)

Basically, the computer functions are generally used as a medium for storing data and in it there are many application programs that can simplify and support a human work. In the warehouse of PT Seyon Indonesia for the process of inventory data management (raw and supporting), reports and data storage is still done manually. The existence of data recording errors and data inaccuracies are very likely to occur in this regard. To help facilitate the management of inventory data (raw and supporting) in the section, the design of the program is the best solution to solve the problems that exist, namely in terms of data processing more accurate because the availability of input form data available and storage media centered in a single database that will make data management of incoming and outgoing goods more effective and efficient. The design of the inventory program (raw and supporting) is made with a simple and interactive appearance but can process data well, so users can easily use it