A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease

We previously showed that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 alleviates motor manifestations of Parkinson's disease in animal models. In the present study, we designed and synthesized monoepoxides of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 and evaluated their biological activity in the MPTP mouse model of Parkinson's disease. We also assessed the ability of these compounds to penetrate the blood-brain barrier (BBB). According to these data, we chose epoxide 4, which potently restored the locomotor activity in MPTP-treated mice and efficiently penetrated the BBB, to further explore its potential mechanism of action. Epoxide 4 was found to robustly promote the survival of cultured dopamine neurons, protect dopamine neurons against toxin-induced degeneration, and trigger the mitogen-activated protein kinase (MAPK) signaling cascade in cells of neuronal origin. Meanwhile, neither the survival-promoting effect nor MAPK activation was observed in non-neuronal cells treated with epoxide 4. In the MPTP mouse model of Parkinson's disease, compound 4 increased the density of dopamine neuron fibers in the striatum, which can highlight its potential to stimulate striatal reinnervation and thus halt disease progression. Taken together, these data indicate that epoxide 4 can be a promising compound for further development, not only as a symptomatic but also as a neuroprotective and neurorestorative drug for Parkinson's disease.Peer reviewe

Дистанционное и радиолокационное исследование ледника Левый Ирбисту (Южно-Чуйский хребет, Республика Алтай)

To determine changes of glacier No. 31 (SU5A15106031), happened in the beginning of the XXI century, satellite images, obtained from the Landsat-7, 8, 9 and Sentinel-2 satellites in different years, were analyzed. As a result, data on the glacier changes were obtained for the period from 2000 to 2022. During this time, the length of the main stream of the glacier decreased by 144 m (6.8%), and the total area of the entire glacier – by 0.089 km2 (9.7%). The rate of retreat of the glacier front varied from 2 to 15 m/year, on average – 6.5 m/year, and the glacier area decreased by on average of 0.004 km2/year. In 2022, the glacier consisted of two separate ice streams, with a total area of 0.823 km2 and a maximum length of 1.955 km. Aerial photography was carried out using a DJI Phantom 4 quadcopter. A high-resolution orthophotoplan (±5 cm), a digital terrain model, a three-dimensional model of the surface of the glacier tongue and adjacent territories, with a total area of 0.25 km2, were made. Radar sounding was performed by the Python-3 georadar in two configurations: at frequencies 50 and 100 MHz. Two cross-sections of the glacier were constructed from the radar data: one was taken at a frequency of 100 MHz, and the second at both – 50 MHz and 100 MHz. The analysis of the radiogram of these profiles made possible to reveal that the larger thickness of the glacier in the study area was measured along the left side of the glacier tongue, the maximum recorded thickness was equal to 66 mНа основе данных ДЗЗ за 2000–2022 гг. выявлено изменение малого ледника № 31 (SU5A15106031), расположенного на Южно-Чуйском хребте Центрального Алтая. За это время ледник сократился на 144 м (на 6.8%) и потерял 0.089 км2 (9.7%) своей площади. Приведены результаты аэрофотосъёмки и радиолокационного зондирования нижней части языка ледника, выполненных в 2022 г

Solar Cell Based on Copper (I) Oxide, and Cadmium Tin Oxide

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.As a solar cell a heterostructure has been proposed that consists of an anode copper oxide Cu2O and a transparent conductive layer Cd—Sn—O obtained via extraction-pyrolytic method. The heterostructure is formed on a copper substrate by means of anodic oxidation with further applying a transparent conductive oxide film. An increase in the efficiency of the Cu2O/Cd–Sn–O element compared with Cu–Cu2O structure has been shown to be possible

Solar Cell Based on Copper (I) Oxide, and Cadmium Tin Oxide

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.As a solar cell a heterostructure has been proposed that consists of an anode copper oxide Cu2O and a transparent conductive layer Cd—Sn—O obtained via extraction-pyrolytic method. The heterostructure is formed on a copper substrate by means of anodic oxidation with further applying a transparent conductive oxide film. An increase in the efficiency of the Cu2O/Cd–Sn–O element compared with Cu–Cu2O structure has been shown to be possible

Zofenopril in the treatment of patients with arterial hypertension and stable coronary heart disease: effects on oxidative stress and flowdependent vasodilatation

Aim. To compare the effects of ACE inhibitors zofenopril and perindopril on endothelial function and oxidative stress (OS) in patients with stable CHD and AH. Material and methods. In total, 40 patients with stable CHD (Functional Class II-III effort angina) and Stage 1-2 AH received zofenopril (7,5-30 mg/d; mean dose 18,6±8,8 mg/d; n=17) or perindopril (2-8 mg/d; mean dose 4,1±2,1 mg/d; n=23) for 12 weeks. At baseline and in the end of the study, all patients underwent reactive hyperemia test (RHT), to assess flow-dependent vasodilatation of brachial artery, and the measurement of OS parameters (malone dialdehyde, MDA, in low-density lipoproteins, MDALDL) and antioxidant parameters (superoxide dismutase (SOD) and glutathione peroxidase (GPO) activity in erythrocytes).Results. In both groups, a similar reduction in systolic and diastolic blood pressure levels was observed. In the zofenopril group, a significant elevation in brachial artery diameter increase during RHT, a significant increase in GPO activity, and some reduction in MDALDL levels were observed, which points to antioxidant system (AOS) activation and OS reduction. No similar changes of these parameters were observed in the perindopril group. Conclusion. In patients with stable CHD and AH, zofenopril, but not perindopril, reduced OS severity and increased AOS system activity, which was associated with improved endothelial-dependent vasodilatation