11 research outputs found
Computation of dynamical correlation functions of Heisenberg chains: the gapless anisotropic regime
We compute all dynamical spin-spin correlation functions for the spin-1/2
anisotropic Heisenberg model in the gapless antiferromagnetic regime,
using numerical sums of exact determinant representations for form factors of
spin operators on the lattice. Contributions from intermediate states
containing many particles and string (bound) states are included. We present
modified determinant representations for the form factors valid in the general
case with string solutions to the Bethe equations. Our results are such that
the available sum rules are saturated to high precision. We Fourier transform
our results back to real space, allowing us in particular to make a comparison
with known exact formulas for equal-time correlation functions for small
separations in zero field, and with predictions for the zero-field asymptotics
from conformal field theory.Comment: 14 page
High rates of parkinsonism in adults with autism
Abstract Background While it is now recognized that autism spectrum disorder (ASD) is typically a life-long condition, there exist only a handful of systematic studies on middle-aged and older adults with this condition. Methods We first performed a structured examination of parkinsonian motor signs in a hypothesis-generating, pilot study (study I) of 19 adults with ASD over 49 years of age. Observing high rates of parkinsonism in those off atypical neuroleptics (2/12, 17 %) in comparison to published population rates for Parkinson’s disease and parkinsonism, we examined a second sample of 37 adults with ASD, over 39 years of age, using a structured neurological assessment for parkinsonism. Results Twelve of the 37 subjects (32 %) met the diagnostic criteria for parkinsonism; however, of these, 29 subjects were on atypical neuroleptics, complicating interpretation of the findings. Two of eight (25 %) subjects not taking atypical neuroleptic medications met the criteria for parkinsonism. Combining subjects who were not currently taking atypical neuroleptic medications, across both studies, we conservatively classified 4/20 (20 %) with parkinsonism. Conclusions We find a high frequency of parkinsonism among ASD individuals older than 39 years. If high rates of parkinsonism and potentially Parkinson’s disease are confirmed in subsequent studies of ASD, this observation has important implications for understanding the neurobiology of autism and treatment of manifestations in older adults. Given the prevalence of autism in school-age children, the recognition of its life-long natural history, and the recognition of the aging of western societies, these findings also support the importance of further systematic study of other aspects of older adults with autism