Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Background: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition

Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium’s possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response — defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P = 9.8 × 10−12, R2 = 1.9%) and continuous (P = 6.4 × 10−9, R2 = 2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22–5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10−4, R2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment

Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

\ua9 The Author(s) 2024.Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD

Air Show : the logistic service of the mass event

W artykule omówiona została problematyka dotycząca zagadnień związanych z organizacją imprez masowych. Przedstawiono zasady organizacji imprezy masowej jako systemu, w którym logistyka jest niezwykle ważnym elementem–przedstawiono zarówno istotę, jak i znaczenie wsparcia logistycznego w organizowaniu imprez o charakterze masowym. Celem artykułu jest przedstawienie procedury organizacji Air Show jako imprezy masowej. W części pierwszej przedstawiono wybrane zagadnienia teoretyczne dotyczące logistycznej obsługi imprez masowych. Przedmiotem rozważań ujętych w drugiej części artykułu jest organizacja imprezy masowej Air Show w Radomiu jako studium przypadku. Wskazano podmioty odpowiedzialne za organizację i finansowanie tego przedsięwzięcia. Przedstawiono szczegółowy harmonogram działań warunkujących prawidłowy przebieg imprezy. Położono nacisk na znaczenie służb odpowiedzialnych za bezpieczeństwo i porządek. Logistyczna obsługa Air Show wiąże się również z zapewnieniem dojazdu do lotniska ze stref parkingowych. Biorąc pod uwagę charakter, w tym rangę i wielkość tego rodzaju wydarzenia, w artykule uwzględniono wszystkie te elementy, które składają się na logistyczną obsługę imprezy masowej - Air Show. Artykuł składa się z dwóch części, teoretycznej - przygotowanej w odniesieniu do uregulowań prawnych stosowanych w zakresie organizacji imprez masowych i empirycznej - opracowanej na podstawie obserwacji i badań własnych przeprowadzonych przez autorki artykułu.In the article there was discussed issues related to organization of the mass events. There was presented rules of organizing a mass event as an element of logistics development – presented both the essence and the importance of logistical support in the organization of the mass events. In the first part there was presented some selected theoretical issues related to logistic service of the mass event. The subject of reflection in the second part of this article is organization of the mass event Air Show in Radom as a case of study. There was indicated the entities responsible for organizing and financing this event. There was presented detailed schedule of activities that will determine the correct course of the event. There was emphasized on the importance of security and ordering services. Logistical service of Air Show is also related to the availability of access to the airport form the parking areas. All these elements make up the logistic service of the mass event, emphasizing the high importance and magnitude of this kind of event

Determinants factors of tourist services market in Masovian voivodeship

W artykule przedstawione zostały, w oparciu o informacje pozyskane ze zbiorów Głównego Urzędu Statystycznego i Instytutu Turystyki, tendencje rozwojowe w zakresie zagospodarowania turystycznego w województwie mazowieckim oraz stopnia wykorzystania bazy hotelowej, ruchu turystycznego, jak również ocena zagospodarowania turystycznego Mazowsza w latach 2008-2011. W pierwszej części rozważań, w ujęciu teoretycznym, wyjaśniono pojęcie rynku turystycznego ze szczególnym uwzględnieniem ewaluacji pojęć turystyka, turysta, zachowania konsumenta na rynku usług turystycznych oraz omówiono elementy rynku usług turystycznych - takie jak popyt, podaż, cena, produkt. W części drugiej rozważań zdefiniowano istotne czynniki, o charakterze ekonomicznym jak i pozaekonomicznym, kształtujące wielkość i strukturę popytu na rynku usług turystycznych. W części trzeciej artykułu zaprezentowano, zarówno w aspekcie teoretycznym jak i empirycznym, potencjał turystyczny województwa mazowieckiego. Uwagę skoncentrowano na wykorzystaniu zagospodarowania turystycznego województwa mazowieckiego oraz wskazaniu kierunków rozwoju bazy materialnej turystyki w tym regionie, w przyszłości. Ponadto scharakteryzowano ruch turystyczny na Mazowszu w kontekście celów podróży, rodzajów wykorzystania miejsc noclegowych i aspektu sezonowości. W podsumowaniu rozważań podjęto próbę wskazania roli i znaczenia rozwoju turystyki na Mazowszu dla kształtowania rozwoju gospodarczo-przestrzennego i społeczno-kulturowego tego regionu. Zwrócono również uwagę na kwestie ograniczania negatywnego wpływu turystyki na środowisko przyrodnicze, jak również strategiczne kierunki rozwoju turystyki w województwie mazowieckim.In the paper presented, based on the information obtained from the collection of the Central Statistical Office and the Institute of Tourism, trends in the development of tourism in the Masovia Voivodship and the degree of use of hotel facilities, tourism, as well as of Mazovia tourist development in the period 2008-2011. In the first part of the theoretical discussion, explains the concept of the tourist market with particular emphasis on the evaluation of concepts tourism, tourist, consumer behavior in the market of tourist services and discusses the elements of the market of tourist services - such as demand, supply, price, product. The second part defines important consideration factors such as an economic and non-economic, shaping the size and structure of the market demand for tourist services. The third part of the article presents, both in terms of the theoretical and empirical tourism potential in Masovia Voivodeship. Attention has focused on the use of tourist development in Masovia providence and indicating directions of development of the material base of tourism in this region inthe future. In addition, tourist traffic is characterized in Mazovia in the context of the purpose of travel, type of accommodation and the use of seasonal aspect. In summary discussion has attempted to identify the role and importance of tourism development in the Mazovia region to shape the development of economic and spatial and socio-cultural heritage of this region. It also drew attention to reduce the negative impact of tourism on the natural environment, as well as the strategic directions of development of tourism in the Masovia voivodeship

Knowledge, skills, social competence in the light of new conditions of National Qualifications Framework for the example of direction tourism and recreation

W artykule omówiony został program kształcenia opracowywany przez Zespół, na kierunku Turystyka i Rekreacja na Uniwersytecie Techniczno-Humanistycznym, w odniesieniu do Krajowych Ram Kwalifikacji z uwzględnieniem wiedzy, umiejętności i kompetencji społecznych. W pierwszej części rozważań zdefiniowane zostały efekty kształcenia jako istota Krajowych Ram Kwalifikacji. W drugiej zaś przedstawione zostały prace Zespołu opracowującego efekty kształcenia na kierunku Turystyka i Rekreacja na Uniwersytecie Technologiczno - Humanistycznym w Radomiu. Zgodnie z przyjętymi założeniami Zespół umiejscowił kierunek ten w trzech obszarach kształcenia, uznając go tym samym jako interdyscyplinarny.The paper discusses the training program developed by the Teamon the faculty of Tourism and Recreation at the University of Technology and Humanities in Radom, in relation to the National Qualifications Framework, taking into account the knowledge, skills and social competence. In the first part of the considerations learning outcomes are defined as being the National Qualifications Framework. In the other hand, presents the work of the Team that developed the education effects on the faculty of Tourism and Recreation at the University of Technology and Humanities in Radom. According to the assumptions, The Team located this faculty in three areas of education, considering it threby as interdisciplinary

Tariff systems in public transport in selected cities

Ceny za usługi przewozowe w miejskim transporcie publicznym stanowią element polityki transportowej i podlegają regulacjom. Cennik opłat za przejazdy komunikacją miejską wynika z ustawy o publicznym transporcie zbiorowym i ustalany jest przez samorząd terytorialny. W artykule przeprowadzona została analiza wprowadzonych przez włodarzy wybranych miast systemów taryfowych. Miastami tymi są: Radom, Częstochowa, Kielce oraz Bydgoszcz.Prices for transport services in urban public transport are an element of transport policy and are subject to regulations. The price list for public transport trips results from the Act on public transport and is determined by the territorial self-government. The article analyzes the tariff systems introduced by the authorities of selected cities. These cities are: Radom, Czestochowa, Kielce and Bydgoszcz

Assessment of the possibilities of using the normal distribution to the description of select parameters of the road traffic in cities on the example of Radom

W artykule omówiono podstawowe zagadnienia dotyczące pomiarów natężenia ruchu. Wskazano na istotne problemy wynikające z konieczności realizacji takich pomiarów w odniesieniu do całego obszaru miejskiego. Ponadto istotnym zagadnieniem poruszonym w artykule jest również możliwość wykorzystania rozkładu normalnego do opisu w aspekcie ilościowym natężenia ruchu drogowego w miastach na przykładzie Radomia.The article discusses the basic issues related to traffic volume. Significant problems resulting from the necessity of such measurements in relation to the entire urban area were pointed out. Moreover, an important issue raised in the article is also the possibility of using the normal distribution to describe the volume of road traffic in cities on the example of Radom