Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Work carried out by JM was funded by the National Institutes of Health (NIH). NIH contract number is HHSN272201000039I/HHSN27200001/ A19

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Trade and Exchange in Anglo-Saxon Wessex, AD 600-780

This paper assesses the provenance and general distribution of coins of the period c 600–c 780 found in the west of Anglo‐Saxon Wessex. It shows that the distribution of coin finds is not a function of the habits of metal detectorists, but a reflection of the real pattern of losses. In the second part of the paper, an analysis of the observed distributions is presented which reveals that the bulk of trade, of which the coins are a sign, was carried on through local ports and that foreign trade was not mediated through Hamwic, but came directly from the continent. The distribution of coin finds also suggests an important export trade, probably in wool and woollen goods, controlled from major local centres. There are also hints of a potentially older trade system in which hillforts and other open sites were important