Efficacy of Combination of Immunotherapies in a Murine in a Murine Squamous Cell Carcinoma Model

Introduction: Head and neck squamous cell carcinomas (HNSCCs) are a type of neoplasm found in the epithelium of the oral cavity, oropharynx, nasopharynx, larynx, or hypopharynx. Recent evidence has demonstrated that 70-90% of HNSCC are associated with Human Papillomavirus (HPV), particularly strain 16 producing oncogenic proteins E6/E7. Currently, HNSCCs are treated with surgery, chemotherapy, and radiation, however immunotherapy with immune checkpoint (PD-1) blocking agents promises to improve outcomes in HNSCC. Objective: This study examined the therapeutic effects of dual and triple combination immunotherapies in a mouse model of HPV-associated HNSCC. Methods: Treatment modalities included a tumor vaccine (attenuated Listeria monocytogenes based vaccine encoding HPV16 E6/E7 (AXAL)), an immune checkpoint inhibitor targeting PD1 (RMP1-14) and topical subtherapeutic radiation. Mice were injected subcutaneously with tumor cells expressing HPV16 E6/E7 (TC-1). When tumors were established, mice were vaccinated with AXAL (3 injections) either alone and/or with anti-PDi and/or with a single dose of radiation. Results: Partial responses were observed in some mice receiving dual combination therapies. Most mice treated with triple immunotherapy revealed complete tumor regression. Discussion: Combination immunotherapy is effective in the TC-1 HNSCC model system. The results obtained set the stage for investing immune mechanism underpinning treatment-associated tumor regression

Influence of labyrinth orientation relative to gravity on responses elicited by stimulation of the horizontal semicircular canals

Gravity labyrinth orientation influence on responses from stimulation of horizontal semicircular canal

Modification of vestibular responses as a function of rate of rotation about an earth-horizontal axis

Vestibular response modifications as function of rotation rate about earth-horizontal axi

Existential Psychotherapies: Similarities and Differences Among the Main Branches

Authors agree that a range of different existential therapies exist. However, not much has been written about what is characteristic and distinctive of each existential therapy, and the few claims that have been made are mainly hypothetical. Practitioners from the four main branches of existential therapy were asked about the authors and texts that have most influenced their practice and the practices they considered most characteristic of existential therapy. From all over the world, 29 daseinsanalysts, 82 existential-humanistic, 573 existential-phenomenological, and 303 logotherapy and/or existential analysis practitioners participated in this study. Data show that the scope of influence of an author is pretty much limited to the branch he or she is related to and only a few authors, in particular Frankl and Yalom, influence practitioners from all four branches. Five categories of practice are shared among the main existential branches as the most characteristics of existential therapy, with phenomenological practices being the most shared category: But the frequency of each of these categories of practice differs significantly depending on respondents’ training or affiliated branch. Data corroborate the idea of different existential therapies, with logotherapy and/or existential analysis being the most markedly different branch of them all

Short-lived solar burst spectral component at f approximately 100 GHz

A new kind of burst emission component was discovered, exhibiting fast and distinct pulses (approx. 60 ms durations), with spectral peak emission at f approx. 100 GHz, and onset time coincident to hard X-rays to within approx. 128 ms. These features pose serious constraints for the interpretation using current models. One suggestion assumes the f approx. 100 GHz pulses emission by synchrotron mechanism of electrons accelerated to ultrarelativistic energies. The hard X-rays originate from inverse Compton scattering of the electrons on the synchrotron photons. Several crucial observational tests are needed for the understanding of the phenomenon, requiring high sensitivity and high time resolution (approx. 1 ms) simultaneous to high spatial resolution (0.1 arcsec) at f approx. 110 GHz and hard X-rays

The possible importance of synchrotron/inverse Compton losses to explain fast mm-wave and hard X-ray emission of a solar event

The solar burst of 21 May 1984, presented a number of unique features. The time profile consisted of seven major structures (seconds), with a turnover frequency of greater than or approximately 90 GHz, well correlated in time to hard X-ray emission. Each structure consisted of multiple fast pulses (0.1 seconds), which were analyzed in detail. A proportionality between the repetition rate of the pulses and the burst fluxes at 90 GHz and greater than or approximately 100 keV hard X-rays, and an inverse proportionality between repetition rates and hard X-ray power law indices were found. A synchrotron/inverse Compton model was applied to explain the emission of the fast burst structures, which appear to be possible for the first three or four structures

Monitoring techniques for the manufacture of tapered optical fibers

The use of a range of optical techniques to monitor the process of fabricating optical fiber tapers is investigated. Thermal imaging was used to optimize the alignment of the optical system; the transmission spectrum of the fiber was monitored to confirm that the tapers had the required optical properties and the strain induced in the fiber during tapering was monitored using in-line optical fiber Bragg gratings. Tapers were fabricated with diameters down to 5 μm and with waist lengths of 20 mm using single-mode SMF-28 fiber

Relações entre a diversidade da fauna de solo e o processo de decomposição e seus reflexos sobre a estabilidade dos ecossistemas.

Agrupamento da fauna de solo em clases de tamanho. A diversidade da fauna de solo. A importância da fauna de solo para o processo de decomposição. Modelo de efeitos reguladores diretos e indiretos. Modelo de teias alimentadores do solo. Modelos hierárquicos de esferas de influência e sistemas biológicos de regulação Modelo de Guildas da fauna de solo. Existe relação entre diversidade e estabilidade. Como um aumento da diversidade da fauna de solo pode afetar a estabilidade do ecossistema.bitstream/CNPAB-2010/27434/1/doc156.pd

Quality of process modeling using BPMN: a model-driven approach

Dissertação para obtenção do Grau de Doutor em Engenharia InformáticaContext: The BPMN 2.0 specification contains the rules regarding the correct usage of the language’s constructs. Practitioners have also proposed best-practices for producing better BPMN models. However, those rules are expressed in natural language, yielding sometimes ambiguous interpretation, and therefore, flaws in produced BPMN models. Objective: Ensuring the correctness of BPMN models is critical for the automation of processes. Hence, errors in the BPMN models specification should be detected and corrected at design time, since faults detected at latter stages of processes’ development can be more costly and hard to correct. So, we need to assess the quality of BPMN models in a rigorous and systematic way. Method: We follow a model-driven approach for formalization and empirical validation of BPMN well-formedness rules and BPMN measures for enhancing the quality of BPMN models. Results: The rule mining of BPMN specification, as well as recently published BPMN works, allowed the gathering of more than a hundred of BPMN well-formedness and best-practices rules. Furthermore, we derived a set of BPMN measures aiming to provide information to process modelers regarding the correctness of BPMN models. Both BPMN rules, as well as BPMN measures were empirically validated through samples of BPMN models. Limitations: This work does not cover control-flow formal properties in BPMN models, since they were extensively discussed in other process modeling research works. Conclusion: We intend to contribute for improving BPMN modeling tools, through the formalization of well-formedness rules and BPMN measures to be incorporated in those tools, in order to enhance the quality of process modeling outcomes