Measurement of the vector and tensor analyzing powers for Dp-elastic scattering at the energy of 800 MeV

The vector Ay and tensor analyzing powers Ayy and Axx for dp-elastic scattering were measured at the energy of 800 MeV and at the angular range from 60° to 135° in the center-of-mass system at the JINR Nuclotron. The experimental data are compared with the calculations obtained within framework of relativistic multiple scattering approac

A computer system for the leukocytes classification in medical images

The paper is about the development of a computer system for the white blood cells images classification. Solving the leukocytes classification task makes it possible to diagnose not only the blood diseases, but also a wide range of other diseases, as well as to evaluate the overall state of a person's health. Modern leukocytes classification methods have a fairly large number of shortcomings, which make a problem of finding the most effective method as a tool to solve this task. In our computer system we use the method based on using a trained convolutional neural network as a binary classifier for the leukocytes classificatio

Guardianship for Popular Sobriety in Russia at the Beginning of 20th Century: from Wine Monopoly to “Dry Law”

The article is devoted to the guardianship of popular sobriety — institutions created by the government of the Russian Empire at the end of the 19th century to organize the fight against excessive alcohol consumption at the provincial and district levels. The study describes the situation with the consumption of alcoholic beverages in Russia at the turn of the XIX—XX centuries, provides the main provisions of the state wine monopoly, introduced in 1895 with the direct participation of the Minister of Finance S. Yu. Witte. Based on the Charter of Guardianship of People’s Sobriety, the authors describe their powers, composition, and features of work organization. Based on the analysis of diverse sources (including unpublished archival sources), the article characterizes the diverse activities of guardianship in Russia at the beginning of the 20th century, as well as its assessment by contemporaries. The conclusion is made about the relatively low efficiency of the work of sober institutions due to their bureaucracy and insufficient funding. The article describes the problem of reforming the guardianship, which was discussed with varying intensity in the 1900—1910s in the Ministry of Finance, the State Council, public and zemstvo circles. Special attention is paid to the analysis of the problems faced by the guardianship of popular sobriety during the First World War after the introduction of the “Prohibition”. The scientific novelty of the research lies in an attempt to analyze the entire set of issues related to the activities of guardianship in the period under review, starting from documents of a legal and office-work nature, statistical materials, periodicals, journalistic and memoir literature

First results on the energy scan of the vector Ay and tensor Ayy and Axx analyzing powers in deuteronproton elastic scattering at Nuclotron

New results on the vector A y and tensor Ayy and Axx analyzing powers in deuteronproton elastic scattering obtained at Nuclotron in the energy range 400-1800 MeV are presented. These data have been obtained in 2016-2017 at DSS setup at internal target station using polarized deuteron beam from new source of polarized ions. The preliminary data on the deuteron analyzing powers in in the wide energy range demonstrate the sensitivity to the shortrange spin structure of the nucleon-nucleon correlation

Spin studies of the short-range correlations at Nuclotron

The results on the angular dependencies of the vector Ay and tensor Ayy and Axx analyzing powers in deuteron-proton elastic scattering at large scattering angles are presented. These data were obtained at internal target at JINR Nuclotron in the energy range 400-1800 MeV using polarized deuteron beam from new polarized ion source. New data on the deuteron analyzing powers in in the wide energy range demonstrate the sensitivity to the short-range spin structure of the isoscalar polarized deutero

EFFECT OF M2 MACROPHAGE-DERIVED SOLUBLE FACTORS ON DIFFERENTIATION OF SH-SY5Y CELLS

Macrophages play a key role in triggering and regulation of neuroregeneration. The characteristic feature of macrophages is pronounced plasticity, which manifests itself in the ability of macrophages to change their functional phenotype depending on the micromilieu. Apoptotic cell clearance (efferocytosis) is an important inducer of a macrophage polarization to M2 phenotype under pathological settings. Previously, we have developed an original protocol for the generation of M2-like macrophages, polarized by efferocytosis under serum-deprived conditions (M2 (LS), Low Serum). The present study was aimed to assess a neuroregenerative potential of M2 (LS) macrophages. We studied their effect on the differentiation of SH-SY5Y cells in comparison with retinoic acid (RA). As the morphological criteria of differentiation we have assessed the relative content of differentiated cells, i.e., cells with a neurite length exceeding the cell body length, and the average neurite length on days 3, 7, and 13. The ratio of neuron-like (N-type) and epithelial-like (S-type) cells in cultures was also assessed. SH-SY5Y cells were characterized by a low level of spontaneous differentiation, both under standard conditions (10% FBS) and serum deprivation (1% FBS). Upon RA treatment, SH-SY5Y cells stopped proliferating and underwent neuronal differentiation. Cultivation of SH-SY5Y cells in the presence of M2 (LS) conditioned medium also led to a significant increase in the relative content of differentiated cells, the average length of neurite-like processes, as well as a change in the balance of S- and N-type cells towards a pronounced predominance of the latter. The morphological features of differentiation were significantly less pronounced at early stage (day 3) of differentiation as compared with the RA-induced changes and reached the level of positive control only at later stages (day 13) (p < 0.05). In contrast to retinoic acid, M2 (LS) conditioned medium induced neuronal differentiation of SH-SY5Y cells without suppressing their proliferative activity. The data obtained may indicate a high neuroregenerative potential of M2 macrophages in vitro, which is realized through soluble factors and manifests itself in promoting SH-SY5Y differentiation

Hydrodynamical Simulation of Astrophysical Flows: High-Performance GPU Implementation

We present a new hydrodynamical code GPUPEGAS 2.0 for 3D simulation of astrophysical flows using the GPUs. This code is an extension of GPUPEGAS code developed in 2014 for simulation of interacting galaxies. GPUPEGAS 2.0 is based on the Authors' numerical method of high order of accuracy for smooth solutions with small dissipation of the solution in discontinuities. The high order of accuracy and small dissipation are achieved by using the piecewise-linear representation of the physical variables in each dimension. The Rusanov flux allows one to simply vectorize the solution of the Riemann problem. The code was implemented for the cluster supercomputers NKS-30T (Siberian Supercomputer Center, SB RAS) and Uran (Institute of Mathematics and Mechanics, UrB RAS) using the hybrid MPI+CUDA technology. To avoid the compute capability-specific implementations of reduction routines, the Thrust library was used. The optimal parameters for kernel function were found for the three-dimensional computation grid. The Sedov point blast problem was used as a main test one. The numerical experiment was performed to simulate the hydrodynamics of the type II supernova explosion for the grid size of 2563. A set of experiments was performed to study performance and scalability of the developed code. The performance of 25 GFLOPS was achieved using a single Tesla M2090 GPU. The speedup of 3 times was achieved using a node with 4 GPUs. By using 16 GPUs, 70% scalability was achieved. © 2019 IOP Publishing Ltd. All rights reserved.Russian Science Foundation, RSF: 18-11-00044The work of Igor Kulikov and Igor Chernykh was supported by Russian Science Foundation (project no. 18-11-00044)

IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY

We have previously shown that acute traumatic brain injury (TBI) is accompanied by increased level of circulating bone marrow progenitors, and favorable outcome is associated with early mobilization of CD34+CD45+ hematopoietic progenitor cells (HP). The present study was aimed at investigating whether patients with early HP mobilization differed from those with mobilization failure by systemic inflammatory reaction and immune parameters. The TBI patients were characterized by increased levels of serum C-reactive protein (CRP), IL-1в, IL-6, IL-8, MCP-1, G-CSF and IL-1ra indicative for presence of systemic inflammatory response. Importantly, patients with lacking mobilization of early HPs were shown to have significantly higher serum levels of CRP, MCP-1, MIP-1в, and G-CSF and a lower level of VEGF. In addition, patients with lack of early HP mobilization differed by significantly lower absolute number of lymphocytes, CD3+ T cells, CD4+ T cells, CD16+ NK cells and proliferative response of mononuclear cells to stimulation with ConA as well as by 4-fold higher rate of infectious complications compared with the opposite group. These data suggest that correlation of early mobilization of CD34+CD45+ cells with a favorable outcome in TBI patients may be partially mediated by anti-inflammatory and immunomodulatory effects of circulating bone marrow progenitors