Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats

0.01). In conclusion, the five-fold higher AUC of mesna in plasma after mesna administration and the fact that mesna is more reactive with (hydrated) cisplatin than its disulphide form BNP7787 represent a plausible explanation as to why mesna administration can reduce the antitumour activity of cisplatin. After BNP7787 administration, the distribution of BNP7787 and mesna was restricted to the kidney, which confirmed the selective protection of the kidney by BNP7787

Protons in near earth orbit

The proton spectrum in the kinetic energy range 0.1 to 200 GeV was measured by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS-91 at an altitude of 380 km. Above the geomagnetic cutoff the observed spectrum is parameterized by a power law. Below the geomagnetic cutoff a substantial second spectrum was observed concentrated at equatorial latitudes with a flux ~ 70 m^-2 sec^-1 sr^-1. Most of these second spectrum protons follow a complicated trajectory and originate from a restricted geographic region.Comment: 19 pages, Latex, 7 .eps figure

Search for antihelium in cosmic rays

The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle Discovery during flight STS-91 in a 51.7 degree orbit at altitudes between 320 and 390 km. A total of 2.86 * 10^6 helium nuclei were observed in the rigidity range 1 to 140 GV. No antihelium nuclei were detected at any rigidity. An upper limit on the flux ratio of antihelium to helium of < 1.1 * 10^-6 is obtained.Comment: 18 pages, Latex, 9 .eps figure

Delayed diagnosis of coeliac disease increases cancer risk

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Observing Christian Faith during the Childhood Years

This paper presents the treasure and cultivate model as a research tool for observing Christian faith in the childhood years. The model seeks to treasure and preserve the natural and innate aspects of a child’s faith and spirituality, whilst simultaneously seeking to develop and cultivate other facets. It is proposed that this balanced approach leads to a childhood faith that is both wholesome and a resource to the child. Observation and logging of a child’s faith in this way provides a tool that allows surveying of characteristics that may influence faith. In the future, this research tool may be used to inform those who seek to foster a child’s religious faith in order that such nurture may be both healthy and resourceful. The paper describes a research project of 61 children aged three to thirteen years old, from six Christian denominations in North West England

An investigation of sleeper voids using a flexible track model integrated with railway multi-body dynamics

This article describes a flexible track system model (FTSM) that represents the track structure for a typical ballasted track, taking into account the flexibility of the rails, the sleeper mass and the resilience of the pad/fastening elements, as well as the ballast support stiffness condition. The detailed track model is integrated into a commercial railway vehicle dynamics software, thus allowing for any vehicle to be simulated onto the flexible track while at the same time taking into account the detailed calculation of the non-linear wheel—rail contact interaction. As an example, the application of the FTSM to the study of hanging sleepers, with respect to the UK Railway Group Standard limits, is presented. This example shows the impact of forces because of hanging sleepers on the vehicle and on the track, and attempts at quantifying the damage made to the track components for the specific conditions simulated