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Amici, Monica

Auricchio, S.

Barbato, M.

Boarino, V.

Campanella, J.

Castellano, E.

Cavalletti, M. L.

Chilovi, F.

Corazza, G. R.

Curzio, M.

De Franceschi, L.

De Vincenzi, Massimo

De Vitis, D.

Dessì, Mariarita

Di Benedetto, Rita

Dore, M. F.

Ercole, E.

Federici, M. D.

Ferrari, A.

Festa, V.

Gasbarrini, G.

Giorgetti, G.

Greco, L.

Grosso, S.

Lo Perfido, S.

Mecchia, Anna

Passaleva, M. T.

Pelli, M. A.

Pennazio, M.

Pera, A.

Perri, F.

Piazzi, L.

Picarelli, A.

Rossini, F. P.

Sandri, G.

Santini, D.

Sategna-Guidetti, Null

Scaggiante, F.

Segato, S.

Silano, Marco

Usai, P.

Volta, Umberto

Zancanella, L.

English

PubMed

Springer - Publisher Connector

Delayed diagnosis of coeliac disease increases cancer risk

Dessì, Mariarita

Sategna-Guidetti, null

Archivio della ricerca- Università di Roma La Sapienza

Background: The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease.
Methods: The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005.
Results: The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally
for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not.
Conclusion: Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in
advancing age

Silano, M

Volta, U

Mecchia, AM

Di Benedetto, R

De Vincenzi, M

Collaborating centers of the Italian registry of the complications of coeliac disease

DESSI', MARIARITA

Sategna Guidetti, Null

GRECO, LUIGI

AURICCHIO, SALVATORE

Archivio della ricerca - Università degli studi di Napoli Federico II

Mecchia, A

Dessì, M

Collaborating, Cotirotcocd

Cineca Institutional Research Information System

Abstract Background The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease. Methods The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005. Results The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p  Conclusion Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age.</p

Di Benedetto Rita

Dessì Mariarita

Mecchia Anna

Volta Umberto

Silano Marco

De Vincenzi Massimo

Directory of Open Access Journals

BMC Gastroenterology

Background: The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease.

Methods: The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005.

Results: The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally

for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not.

Conclusion: Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in

advancing age

Dessì, M

Archivio della Ricerca - Università di Roma Tor vergata

Marco Silano

Umberto Volta

Anna Maria Mecchia

Mariarita Dessì

Rita Di Benedetto

Massimo De Vincenzi

A Fasano

U Volta

J West

NH Fairly

KR Gough

C Catassi

PH Green

SD Rampertab

PD Howdle

M Silano

CM Swinson

J Askling

TR Card

U Peters

G Corrao

GK Holmes

LJ Egan

HM Lewis

National Institutes of Health

HJ Freeman

CJ Bruno

Crossref

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Delayed diagnosis of coeliac disease increases cancer risk

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