Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

Four distinct subsets of invariant natural killer T (NKT) cells are shown to differentiate in the thymus, then migrate to peripheral tissues where they retain their phenotypic and functional characteristics

The transferability of information and communication technology skills from university to the workplace: A qualitative descriptive study

Aim: This paper presents the findings from a study that explored whether the information and communication technology (ICT) skills nurses acquired at university are relevant and transferable to contemporary practice environments. Background: Whilst universities have attempted to integrate information and communication technology into nursing curricula it is not known whether the skills developed for educational purposes are relevant or transferable to clinical contexts. Methods: A qualitative descriptive study was used to explore the perspectives of a small group of new graduate nurses working in a regional/semi-metropolitan healthcare facility in New South Wales, Australia. Semi-structured interviews were used and the data thematically analysed. Findings: The themes that emerged from the study are presented in accordance with the conceptual framework and structured under the three headings of pre-transfer, transition and post-transfer. The transferability of information and communication technology skills from university to the workplace is impacted by a range of educational, individual, organisational and contextual factors. Conclusion: Access to adequate ICT and the necessary training opportunities influences new graduates' work satisfaction and their future employment decisions. The ability to effectively use information and communication technology was viewed as essential to the provision of quality patient care. © 2010 Elsevier Ltd

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

Bovine spongiform encephalopathy (BSE) and its human equivalent, variant Creutzfeldt–Jakob disease (vCJD), are caused by the same strain of infectious agent, which is similar to, but distinct from, >20 strains of their sheep scrapie homologue. A better understanding of the molecular strain determinants could be obtained from cells in monoculture than from whole animal studies where different cell targeting is commonly a strain-related feature. Although a few cell types can be infected with different strains, the phenotypes of the emergent strains have not been studied. We have cured the scrapie-infected, clonal SMB cell line with pentosan sulfate, stably re-infected it with a different strain of scrapie and shown that biological properties and prion protein profiles characteristic of each original strain are propagated faithfully in this single non-neuronal cell type. These findings attest to the fact that scrapie strain determinants are stable and host-independent in isolated cells

Africa Insight

Africa Insight is an independent publication which endeavours to promote insight into the process of change and development in AfricaThis journal focuses on contemporary issues of Afric

Africa Insight

Africa Insight is an independent publication which endeavours to promote insight into the process of change and development in AfricaThis journal focuses on contemporary issues of Afric

Medievalism, Modernity and Memory: Cropthorne Church, 1892–1910

Recorded in the Domesday Survey for Worcestershire (1086), the Church of St. Michael in Cropthorne, Worcestershire is an ancient building with a rich history. Drawing on surviving manuscript and visual sources, this article examines the repairs, restoration and refurbishments made to the interior of St. Michael’s between 1890 and 1910. This was a period in which the ownership of the village shifted from the Anglican Church to private patronage and a time which witnessed many changes to the fabric of the building; notably the extensive refurbishments carried out to the chancel in 1894 by Francis Holland, the Lord of the Manor and the restoration of the rest of Cropthorne church which took more than eighteen years to complete. Highlighting the significance of the Church in rural areas as a place for personal and community memory, this article will consider how these changes to a sacred space used for communal worship were linked to the social changes experienced by the rural community that worshipped within it: moving beyond a purely architectural survey of the building, it will identify the agents of these changes; the processes involved in accomplishing them; and, responses to these alterations. Consequently, the alterations and additions to the interior of St. Michael’s made at the instigation and expense both of the Holland Family of Cropthorne Court and the people of Cropthorne will be analyzed in the context of the changing religious, technological, social, economic and political conditions of the period, which include the effects of the Agricultural Depression and the devastating impact of war