Podcasting practices: Mediators of archival work, ELA teacher education curricula, and digital identities

This paper investigates how a semester-long online course in a language and literacy teacher education department coupled a podcast project with archival pedagogy and restorying to explore how ELA (English Language Arts) teachers (preservice, inservice teachers, and those seeking re-entry) worked collaboratively to enrich understandings of instruction embedded in a high-tech environment. The course was taught in the southeastern United States at the height of a global pandemic. After the semester ended, three graduate students (from a class of 21) joined the instructor to qualitatively analyze data collected during the previous 14 weeks. Data sources included digitally stored videos, archived library objects, class emails, rubrics, asynchronous discussion boards, synchronous Zoom discussions, and student-generated podcast projects. Findings point to the merit of providing agentic-learning opportunities through podcasting practices that mediated students’ archival work, ELA teacher education curricula, and digital identity formation. Implications are drawn for ELA classroom teachers and teacher educators

Model Kaji Tindak Program Pembangunan Partisipatif Pengentasan Kemiskinan Dan Rawan Pangan

The objective of the article was to explain essential and urgency of the model of participative development program as an effort to maximize real potencies: economy, social, poli- tic and local culture, so that they can meet living need themselves independently and sustainability. The subjects of the study are all local poor people in Bringin rural area. Result of the research indicated that people awareness can maximize their potency that determined by the creativity and not due to the facility as government gave. The research explained that the incapable people problem was not merely due to absence of capital. However, it was due to awareness and working ethos that awakening in order to resolve the poverty problem. Therefore, in the evaluative action at least it was required four pillars, namely: job opportunity, social protection, capability improvement and people-empowering pillars. Then, evaluative action implementation of widening empowerment program based on local resource and creative economy was an essential, urgent strategy model to develop as effort of resolving poverty

Economic Policy Impact on Competitiveness and Efficiency of Textile Industry in Central Java

The purpose of this research was to determine the competitiveness and efficiency as well as assessing the impact of economic policies on the performance of the textile industry in Central Java. The competitiveness methods use a RCA, TSI, and IIT Indexes. The policy impacts use Policy Analysis Matrix and sensitivity analysis. The results show that the textile industry in Central Java had only a comparative advantage, but not competitive one. The lower protection level made the textile industry was vulnerable to both internal and external shocks. In general economic efficiency was still lower, so it had lower effect on the productivity and competitiveness level

Implementasi Metode Pengaruh Area Untuk Perhitungan Cadangan Bijih Nikel

Perhitungan persediaan bahan yang berada di dalam tanah memerlukan suatu me/ode perhitungandengan keakurasian yang tinggi sehingga dapat lebih akurat dalam memperkirakan persiapankegialan eksploatasinya. Kebutuhan alat yang dapat menghitung dengan lebih keakurasian tersebutdapat disediakan dengan menggunakan aptikasi perhitungan cadangan material. Tulisan inimembahas tentang proses perhitungan perkiraan cadangan khususnya untuk komoditi Nikel denganmetode luas pengaruh. Metode ini melakukan perhitungan cadangan bijih nikel melalui penyesuaianformat data hasil analisis dari lapangan (analisa eksplorasi data) dan mengelompokkan spesifikasibijih nikel dengan sistem zonasi. Selanjutnya dilakukan perhitung masing-masing hasilpengelompokan tersebut dengan cara mengkompositkan masing-masing titik berdasarkankarakteristik yang telah dideklarasikan. Proses terakhir adalah menghitung total nilai volume dantonase dari cadangan. Percobaan telah dilakukan menggunakan basis data bor denganmembandingkan proses perhitungan dengan aplikasi Datamine dan menghasilkan nilai hasilperhitungan yang berbeda hanya 0.03% dan efisiensi waktu yang sangat signifikan yaitu 1 jam(proses dilakukan pada aplikasi yang dibuat berbanding 1 bulan (proses dilakukan pada aplikasiDatamine). Sistem ini diharapkan mampu memberikan informasi cadangan dari basis data hasilanalisa

What is the evidence base of used aggregated antibiotic resistance percentages to change empirical antibiotic treatment? A scoping review

Contains fulltext : 251404.pdf (Publisher’s version ) (Open Access)OBJECTIVES: Antibiotic resistance requires continuous monitoring by experts to decide whether empirical antibiotic therapies (EATs) should be replaced by alternative antibiotics. The exact moment and criteria for this change are unclear and generally based on consensus between experts. This scoping review aims to identify from the literature the resistance thresholds used for a change in EAT and the criteria on which they are based. METHODS: Scoping review for which a comprehensive structured literature search was conducted. Rayyan, software for systematic reviews, was used for the screening of abstracts and titles. Data sources were Pubmed and a hand-search of reference lists and grey literature. Papers were eligible if they concerned any type of bacterial infectious disease and mentioned or defined antibiotic resistance thresholds for decision-making purposes for EAT. The inclusion and analysis of articles was done by two researchers; any conflicts were resolved through discussion or by consulting a third reviewer. RESULTS: We identified 3146 unique papers. Following title/abstract screening, 125 papers were comprehensively read, and 16 papers were included. The included papers gave thresholds for urinary tract infections, respiratory tract infections, meningitis, skin and soft tissue infections, gonorrhoea, and bone and joint infections. Six criteria were found that were commonly used to base the thresholds on. These were: disease severity, efficacy of treatment, adverse drug events, risk of Clostridioides difficile infection, costs, and increased resistance. The number of criteria used to define each threshold varied from one to six between papers. CONCLUSIONS: The thresholds used for EATs are few, commonly based on expert opinion estimates, and can therefore have broad ranges. Used criteria underlying reported thresholds are heterogenous and require standardization. Considering the rising trend in resistance, there is a clear need for rigid tools to determine thresholds in order to support guideline development with the best and timely evidence

Researching the use of force: The background to the international project

This article provides the background to an international project on use of force by the police that was carried out in eight countries. Force is often considered to be the defining characteristic of policing and much research has been conducted on the determinants, prevalence and control of the use of force, particularly in the United States. However, little work has looked at police officers’ own views on the use of force, in particular the way in which they justify it. Using a hypothetical encounter developed for this project, researchers in each country conducted focus groups with police officers in which they were encouraged to talk about the use of force. The results show interesting similarities and differences across countries and demonstrate the value of using this kind of research focus and methodology

The most efficient and effective BRCA1/2 testing strategy in epithelial ovarian cancer:Tumor-First or Germline-First?

Objective: Genetic testing in epithelial ovarian cancer (OC) is essential to identify a hereditary cause like a germline BRCA1/2 pathogenic variant (PV). An efficient strategy for genetic testing in OC is highly desired. We evaluated costs and effects of two strategies; (i) Tumor-First strategy, using a tumor DNA test as prescreen to germline testing, and (ii) Germline-First strategy, referring all patients to the clinical geneticist for germline testing.Methods: Tumor-First and Germline-First were compared in two scenarios; using real-world uptake of testing and setting implementation to 100%. Decision analytic models were built to analyze genetic testing costs (including counseling) per OC patient and per family as well as BRCA1/2 detection probabilities. With a Markov model, the life years gained among female relatives with a germline BRCA1/2 PV was investigated.Results: Focusing on real-world uptake, with the Tumor-First strategy more OC patients and relatives with a germline BRCA1/2 PV are detected (70% versus 49%), at lower genetic testing costs (€1898 versus €2502 per patient, and €2511 versus €2930 per family). Thereby, female relatives with a germline BRCA1/2 PV can live on average 0.54 life years longer with Tumor-First compared to Germline-First. Focusing on 100% uptake, the genetic testing costs per OC patient are substantially lower in the Tumor-First strategy (€2257 versus €4986).Conclusions: The Tumor-First strategy in OC patients is more effective in identifying germline BRCA1/2 PV at lower genetic testing costs per patient and per family. Optimal implementation of Tumor-First can further improve detection of heredity in OC patients.</p

Modified Delphi procedure-based expert consensus on endpoints for an international disease registry for Metachromatic Leukodystrophy:The European Metachromatic Leukodystrophy initiative (MLDi)

BACKGROUND: Metachromatic Leukodystrophy (MLD) is a rare lysosomal disorder. Patients suffer from relentless neurological deterioration leading to premature death. Recently, new treatment modalities, including gene therapy and enzyme replacement therapy, have been developed. Those advances increase the need for high-quality research infrastructure to adequately compare treatments, execute post-marketing surveillance, and perform health technology assessments (HTA). To facilitate this, a group of MLD experts started the MLD initiative (MLDi) and initiated an academia-led European MLD registry: the MLDi. An expert-based consensus procedure, namely a modified Delphi procedure, was used to determine the data elements required to answer academic, regulatory, and HTA research questions. RESULTS: Three distinct sets of data elements were defined by the 13-member expert panel. The minimal set (n = 13) contained demographics and basic disease characteristics. The core set (n = 55) included functional status scores in terms of motor, manual, speech and eating abilities, and causal and supportive treatment characteristics. Health-related quality of life scores were included that were also deemed necessary for HTA. The optional set (n = 31) contained additional clinical aspects, such as findings at neurological examination, detailed motor function, presence of peripheral neuropathy, gall bladder involvement and micturition. CONCLUSION: Using a modified Delphi procedure with physicians from the main expert centers, consensus was reached on a core set of data that can be collected retrospectively and prospectively. With this consensus-based approach, an important step towards harmonization was made. This unique dataset will support knowledge about the disease and facilitate regulatory requirements related to the launch of new treatments. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-022-02189-w

CYP2C19 genotype-guided antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease: study design of a randomized controlled trial (GENPAD)

BACKGROUND: Clopidogrel is recommended in international guidelines to prevent arterial thrombotic events in patients with peripheral arterial disease (PAD). Clopidogrel itself is inactive and metabolism is dependent on the CYP2C19 enzyme. About 30% of Caucasian PAD patients receiving clopidogrel carry 1 or 2 CYP2C19 loss-of-function allele(s) and do not or to a limited extent convert the prodrug into its active metabolite. As a result, platelet inhibition may be inadequate which could lead to an increased risk of adverse clinical events related to arterial thrombosis. A CYP2C19 genotype-guided antithrombotic treatment might be beneficial for PAD patients. METHODS: GENPAD is a multicenter randomized controlled trial involving 2,276 PAD patients with an indication for clopidogrel monotherapy. Patients with a separate indication for dual antiplatelet therapy or stronger antithrombotic therapy are not eligible for study participation. Patients randomized to the control group will receive clopidogrel 75 mg once daily without pharmacogenetic guidance. Patients randomized to the intervention group will be tested for carriage of CYP2C19 *2 and *3 loss-of-function alleles, followed by a genotype-guided antithrombotic treatment with either clopidogrel 75 mg once daily for normal metabolizers, clopidogrel 150 mg once daily for intermediate metabolizers, or acetylsalicylic acid 80 mg once daily plus rivaroxaban 2.5 mg twice daily for poor metabolizers. The primary outcome is a composite of myocardial infarction, ischemic stroke, cardiovascular death, acute or chronic limb ischemia, peripheral vascular interventions, or death. The secondary outcomes are the individual elements of the primary composite outcome and clinically relevant bleeding complications. CONCLUSION: The aim of the GENPAD study is to evaluate the efficacy, safety, and cost-effectiveness of a genotype-guided antithrombotic treatment strategy compared to conventional clopidogrel treatment in PAD patients