Use of Technogenic Silica Fume and Brown Coal Semi-Coke in the Technology of Silicon Carbide

The paper describes thermodynamic experiments to determine the optimal temperature and time modes for the carbide production process from the briquette charge comprising silica fume and brown coal semi-coke, conditions for chemical enriching of silicon carbide, its phase, chemical and granulometric compositions and particle morphology

Features of microbiological diagnosis and choice of selective antibiotic therapy in patients with acute cholecystitis

The objective: to improve the results of destructive forms of acute cholecystitis (AC) surgery by the development of antibiotic therapy algorithm and taking into account the severity of the disease according to Tokyo guidelines (2013). Materials and methods: 266 patients having been operated on for AC made up a treatment group and 203 patients - the control one. In 234 treatment group patients microflora’s bacteriological study was carried out and its selective sensitivity to antibiotics was determined. Results and discussion. The AC treatment group patients (n=266) were arranged according to Tokyo guidelines (2013) into 3 grades. Mild course (grade I) consisted of 29 patients (11%), microbiological studies were not conducted. Antibiotic prophylaxis with beta-lactam antibiotics was used. At moderately severe AC (grade II, n = 200, 75%) escalation antibiotic therapy was carried out. At severe disease (grade III, n = 37, 14%) de-escalation antibiotic therapy was performed. Bacteriological studies were conducted in 237 patients with destructive forms of AC, at that 531 microflora isolates were cultured. Intestinal group microorganisms were the most frequently cultured. Beta-lactam antibiotics’ sensitivity was prevailing and constituted 83.3%. The number of suppurations in the treatment group decreased from 9.8% to 4.3%, and mortality rate decreased from 1.48% to 0.75% (

E-learning as a modern resource of education

E-learning is becoming increasingly popular today. It is being widely implemented not only in educational institutions but in business and industrial enterprises demanding the fastest and the cheapest means of information exchange and communication. This article is dedicated to eliciting of the background factors of successful implementation and favourable environment to develop e-learning programs. It analyses the e-learning teaching process and methods practiced in several countries, including Russia, and empathizes the major issues and problems the national systems of education have had to face recentl

Use of Technogenic Silica Fume and Brown Coal Semi-Coke in the Technology of Silicon Carbide

The paper describes thermodynamic experiments to determine the optimal temperature and time modes for the carbide production process from the briquette charge comprising silica fume and brown coal semi-coke, conditions for chemical enriching of silicon carbide, its phase, chemical and granulometric compositions and particle morphology

Late Antiquity: the regional specific nature of intellectual tradition

The primary purpose of the study is to investigate the specifics of the intellectual tradition prevailing in some regions of the Late Antique world. For the purpose of a comprehensive review of the problem, the authors focus on wellknown intellectuals of the 5th-6th centuries, representing Gaul (Ausonius, Sidonius, Ennodius et al.), Alexandria (John Philoponus, Hypatia, Sinesius of Cyrene et al.), Africa (Fulgentius, Priscian, Corippus), Isauria (Candidus Isaurus

Evaluation of the influence of Inosine pranobex on the matrix protein system in patients with chronic viral cervicitis

The reproductive potential of both women and men is declining every year. Many factors contribute to the violation of the reproductive function – chemical, physical, mechanical, psychogenic, however, biological factors have the most pronounced effect on reproduction. Chronic viral cervicitis can be not only the cause of infertility and reproductive losses, but also the development of intraepithelial dysplasia, as well as cervical cancer. PVI, as a monoinfection, is quite rare along with HPV. Other UGIs (urogenital infections) act as common routes of transmission and entry gates. The most common association with PVI is herpesvirus infection. An increase in MMP, both systemically and at the local level, may indicate a violation of cell modeling processes, which contributes to the development of autoimmune inflammation with further destruction of the tissues of the reproductive tract. Activation of MMP promotes the release of HSV from the nerve ganglia and reactivation of the infection. Therapy for HPV and HVI (herpes virus infections) are debatable. There is no single standard of treatment, but there are a number of drugs that have antiviral and immunomodulatory effects. Currently, there are no studies on the dynamics of the effect of HPV and HSV infection on the state of MMPs and TIMPs during Inosine pranobex therapy. Objective: to evaluate changes in matrix metalloproteinases 2 and 9 and their tissue inhibitors types 1 and 2 in patients with human papillomavirus and herpes infections after Inosine pranobex therapy. 6 patients with papillomavirus and herpetic infections were examined and treated with drugs containing the active ingredient Inosine pranobex. The levels of MMP-2, MMP-9 and TIMP-1, TIMP-2 in blood serum were determined using specific reagents from R&D Diagnostics Inc. (USA). The dynamics of indicators in the blood serum of patients with PVI showed a decrease in the level of MMP-2, MMP-9, TIMP-1 with a simultaneous increase in TIMP-2 relative to the values before therapy. In patients with PVI and HVI, Inosine pranobex therapy showed a decrease in MMP-2 and MMP-9 levels, no changes in the content of TIMP-1, but an increase in the serum content of TIMP-2. Prior to the use of therapy, an increase in the ratio in the main groups in comparison with the control group was found, however, the largest increase was found in the group with the association of infections. After therapy, positive dynamics was established in the main groups. Thus, the ratio in group I decreased and became equal to the control values. In the II group of patients, the ratio, despite the decrease, remained higher than the control values and higher in comparison with the I group of women

Indicators of the cytokine system in practically healthy women of different ages and interrelation with the emotional state

Numerous studies show the role of the cytokine network in the pathogenesis of anxiety and depression. However, at present, studies of the correlation between the levels of pro-inflammatory and antiinflammatory cytokines and the level of emotional stress are rather few. The aim of the study was to analyze the serum levels of pro-inflammatory and anti-inflammatory cytokines and the emotional state in apparently healthy women depending on age. Serum levels were tested IL-1β, IL-6, IL-17, IFNγ, IL-10 and IL-4 in 100 apparently healthy women, who were divided into 3 groups depending on age (WHO): 18-44 (young age) 30 people, 45-59 (middle age) 40 people, 60-74 (old age) 30 people (sandwich variant of enzyme-linked immunosorbent assay, pg/mL). To assess the emotional component of health, all the subjects passed the questionnaire SF-36 “Assessment of the quality of life”. Statistical processing of the obtained data was carried out using the analytical software IBM SPSS Statistics, 22.0. In practically healthy women, an increase in the values of IL-1β and IL-6 was found in the elderly group (p < 0.05), while no differences were found between the groups of young and middle age. The level of IFNγ in all age groups of women did not differ significantly. At the same time, in the elderly group, the levels of IFNγ in 40% ranged from 1.04 to 8.76 pg/mL, and in 60% of women – from 24.85 to 28.5 pg/mL. IL-17 was also high (p < 0.05-0.01) in the group of women aged 60-74. In the anti-inflammatory link, the opposite picture was observed, for example, in young and middle-aged women, the levels of IL-10 and IL-4 were higher than in the elderly group. Thus, the analysis made it possible to state that the parameters of the cytokine profile and emotional state in women are associated with age

Quantum Entanglement in Nitrosyl Iron Complexes

Recent magnetic susceptibility measurements for polycrystalline samples of binuclear nitrosyl iron complexes [Fe_2(C_3H_3N_2S)_2(NO)_4] (I) and [Fe_2(SC_3H_5N_2)_2(NO)_4] (II), suggest that quantum-mechanical entanglement of the spin degrees of freedom exists in these compounds. Entanglement E exists below the temperature T_E that we have estimated for complexes I and II to be 80-90 and 110-120 K, respectively. Using an expression of entanglement in terms of magnetic susceptibility for a Heisenberg dimer, we find the temperature dependence of the entanglement for complex II. Having arisen at the temperature T_E, the entanglement increases monotonically with decreasing temperature and reaches 90-95% in this complex at T=25 K, when the subordinate effects are still small.Comment: 8 page

Protecting Mice from H7 Avian Influenza Virus by Immunisation with a Recombinant Adenovirus Encoding Influenza A Virus Conserved Antigens

Influenza is a highly contagious disease that causes annual epidemics and occasional pandemics. Birds are believed to be the source of newly emerging pandemic strains, including highly pathogenic avian influenza viruses of the subtype H7. The aim of the study: to evaluate the ability of the recombinant human adenovirus, serotype 5, which expresses genes of influenza A highly conserved antigens (ion channel M2 and nucleoprotein NP), to provide protection to laboratory mice against infection with a lethal dose of avian influenza virus, subtype H7. To achieve this goal, it was necessary to adapt influenza A virus, subtype H7 for reproduction in the lungs of mice, to characterise it, and to use it for evaluation of the protective properties of the recombinant adenovirus. Materials and methods: avian influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) was adapted for reproduction in the lungs of mice by repeated passages. The adapted strain was sequenced and assessed using hemagglutination test, EID50 and LD50 for laboratory mice. BALB/c mice were immunised once with Ad5-tet-M2NP adenovirus intranasally, and 21 days after the immunisation they were infected with a lethal dose (5 LD50) of influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) in order to assess the protective properties of the recombinant adenovirus. The level of viral shedding from the lungs of the infected mice was evaluated by titration of the lung homogenates in MDCK cell culture on days 3 and 6 after infection. The level of specific antibodies to H7 avian influenza virus was determined by indirect enzyme immunoassay. Results: the use of Ad5-tet-M2NP adenovirus for immunisation of the mice ensured 100% survival of the animals that had disease symptoms (weight loss) after their infection with the lethal dose (5 LD50) of H7 avian influenza virus. The study demonstrated a high post-vaccination level of humoral immune response to H7 avian influenza virus. The virus titer decreased significantly by day 6 in the lungs of mice that had been immunised with Ad5-tet-M2NP compared to the control group. Conclusion: the Ad5-tetM2NP recombinant adenovirus can be used to create a candidate pandemic influenza vaccine that would protect against avian influenza viruses, subtype H7, in particular

QTL АНАЛИЗ МОРФОЛОГИЧЕСКИХ ПРИЗНАКОВ КАЧЕСТВА У BRASSICA RAPA L.

Using of the DH–lines of two mapping populations of Brassica rapa L, the morpho–biological investigation and mapping of QTLs determined some morphological traits of quality in greenhouse's condition have been done. The linkage groups of QTLs of the following quantitative traits have been identified and localized: length, width, color, hairiness, and surface of lamina, as well as petiole length and width caused of nutritive value of B. rapa plants. The molecular markers genetically linked with mapped QTLs were revealed. The percent of phenotypic variability determined by the identified chromosome loci was calculated.С использованием линий двойных гаплоидов двух картирующих популяций Brassica rapa L. проведено морфобиологическое изучение и картирование QTL (quantitative trait loci), определяющих проявление ряда морфологических признаков качества в условиях теплицы. Идентифицированы и локализованы на группах сцепления QTL таких признаков качества, как длина, ширина, окраска, опушенность, характер поверхности листовой пластинки, а также длина и ширина черешка, обуславливающих питательную ценность данного вида растений. Выявлены молекулярные маркеры, генетически сцепленные с картированными QTL, и установлен процент фенотипической изменчивости, определяемый идентифицированными локусами хромосом