66 research outputs found
An Investigation of Haury and Ballard\u27s Method of Production of Diketones as Applied to Diketones with Aromatic Nuclei
This investigation was undertaken to determine the feasibility of preparing aromatic diketones by the new and novel method proposed by Haury and Ballard
ChemInform Abstract: 1-(2-Nitrophenyl)thiosemicarbazides: A Novel Class of Potent, Orally Active Non-Peptide Antagonists for the Bradykinin B2 Receptor.
ChemInform Abstract: Synthesis and Reactivity of Lithiated γ-Functionalized Ketene Dithioacetals. Generation of a Flexible β-Lithioacrylate Equivalent.
ChemInform Abstract: Synthesis and Lithiation of γ,γ-Difunctionalized Ketene Dithioacetals. Access to a New Synthetic Equivalent of a β-Hydroxy-β-lithioacrylate. X-Ray Molecular Structure of 2-(1,3-Dithian-2-ylidenemethyl)-1,3-dithiane.
A non-peptide antagonist unusually selective for the human form of the bradykinin B2 receptor
Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model
Metals, including iron, are present at high concentrations in amyloid plaques in individuals with Alzheimer's disease, where they are also thought to be cofactors in generating oxidative stress and modulating amyloid formation. In this study, we present data from several Drosophila models of neurodegenerative proteinopathies indicating that the interaction between iron and amyloid beta peptide (Aβ) is specific and is not seen for other aggregation-prone polypeptides. The interaction with iron is likely to be important in the dimerisation of Aβ and is mediated by three N-terminal histidines. Transgenic fly lines systematically expressing all combinations of His>Ala substitutions in Aβ were generated and used to study the pathological role of these residues. Developmental eye phenotypes, longevity and histological examinations indicate that the N-terminal histidines have distinct position-dependent and -independent mechanisms. The former mediate the toxic effects of metals and Aβ aggregation under non-oxidising conditions and the latter are relevant under oxidising conditions. Understanding how Aβ mediates neurotoxic effects in vivo will help to better target pathological pathways using aggregation blockers and metal-modifying agents
3D QSAR studies on new piperazine derivatives with antihistamine and antibradykinin effects
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