Anesthesia management in cesarean section with lown ganong levine syndrome

Lown Ganong Levine (LGL) which is a preexcitation syndrome is defined with paroxysmal tachycardia, dyspnea, anxiety, angina, and the complaint of fatigue accompanied by characteristic changes on ECG (short PR). Herein, we present a case of cesarean which we completed with a low-dose spinal anesthesia without problem, avoiding from general anesthesia which could be induced with numerous arrhythmogenic drugs, because of arrhythmia complication which might be mortal. [Med-Science 2018; 7(4.000): 951-2

Anesthetic Management of a Patient with Motor-sensory polyneuropathy [Motor-Duyu Polinoropatili Olguda Anestezi Yonetimi]

Polyneuropathy that characterized by diffuse axonal degeneration or multifocal segmental demyelination is neuropathy and usually influence peripheral nerves. It can lead to respiratory failure with muscle weakness, atrophy, fasciculations, the involvement of the respiratory muscles. Increased risk of malignant hyperthermia, potential airway problems that may develop after extubation with effected the respiratory muscles, prolonged duration of recovery from non-depolarizing neuromuscular blockade, the discussion of the used neuraxial anesthesia makes anesthesia management important in patient with polyneuropathy. In this presentation aimed to provide general anesthesia management without neuromuscular blockade a patient with motor-sensory polyneuropathy mainly demyelinating who underwent posterior instrumentation due to scoliosis. [Med-Science 2016; 5(3.000): 884-8

Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behets syndrome patients

The role of mutations in NLRP3 in inflammatory features of Behets syndrome.Behets syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like receptor with a pyrin domain 3) inflammasome, as a result of mutation(s), we performed single-strand conformation polymorphism analyses and/or sequencing of all the coding regions and intronexon boundaries of NLRP3/cryopyrin and ASC (apoptosis-associated speck-like protein containing CARD) genes from Turkish BS patients and healthy controls. At the same time, we determined pro-inflammatory cytokine secretion profiles of peripheral blood cells in response to LPS treatment using ELISA. BS patients with vascular involvement showed significantly increased levels of TNF- release at 2-, 4- and 8-h post-treatment and significantly increased IL-1 levels were detected at 2h (P 0.005) and 4h (P 0.025) (n 10). We identified four mutations in the NLRP3/cryopyrin gene, V200M (n 3/104) and T195M (n 1/104), in BS patients but none in control samples. No mutations were detected in the ASC gene. The effect of these NLRP3/cryopyrin mutants on ASC speck assembly and IL-1 secretion was tested and the V200M mutant was shown to induce IL-1 secretion. Thus, it is likely that certain mutations in NLRP3/cryopyrin in combination with yet unknown other factors may contribute to the pro-inflammatory cytokine profiles in BS patients