PREDICTORS OF INTERNATIONAL SKI FEDERATION DISTANCE CROSS-COUNTRY RANKING

The Internationl Ski Federation (FIS) ranks Nordic skiers internationally based on race performance. This study aimed to determine if a relationship exists between FIS rankings and performance indicators such as maximum oxygen uptake, metabolic economy, and muscular endurance test performance. Muscular endurance (sit-up + pull-up and push-up + pull-up) were the best predictors utilizing stepwise regression resampling cross-validation (66 hold out groups). The sit-up + pull-up regression was a better fit than the push-up + pull-up (R2 = 0.506 & 0.349, p = 0.053 & 0.203, respectively). Muscular endurance test performance predicts FIS scores better than measures of oxygen consumption measures. Upper-body and core musculature may be an important determinant of performance, as it contributes to generation of propulsive forces in Nordic skiing

The Top 50 Most Cited Articles on the Medial Patellofemoral Ligament (MPFL): A Bibliometric Analysis

Objectives: To determine which original articles on the topic of the medial patellofemoral ligament (MPFL) have been cited the most in the literature utilizing a bibliometric approach. Secondarily, to determine temporal trends between article types. Methods: Articles on the topic of the MPFL were identified by utilizing the Web of Science Database. The search yielded 1,596 results and the top 50 cited original articles were collected for further analysis. The following information was gathered for all included articles: title, first author\u27s name, journal name, year of publication, impact factor of the journal in 2021, total number of citations of the article, average citations per year (ACY), geographic origin, institutions, research theme, and keywords. Articles were then grouped into one of three categories: cadaveric/anatomic, clinical, and radiologic. Results: The total number of citations was 10,393. Publication dates ranged from 1992 to 2015 and majority of articles originated in the United States (38%). Most were published between the years 2000-2009 (66%) and in the journal, American Journal of Sports Medicine (34%). The mean ACY was 11.73 ± SD 5.86 and the Kawasaki Municipal Hospital was the institution with the most articles included in the top 50 (n=6, 12%). The top-cited articles focused on 3 themes: cadaveric/anatomic (n=18, 36%), clinical (n=25, 50%), and radiologic (n=7, 14%). Cadaveric/anatomic articles had the highest average number of citations at 271.4 ± 153.9, followed by radiologic (173.3 ± 53.0) and clinical articles (171.8 ± 102.4). The two most common keywords were “medial patellofemoral ligament” (53%) and “patella” (23%). Over time, clinical articles were more likely to be included in the top 50 list, compared to cadaveric/anatomic/radiologic articles. Conclusion: The current study showcased that the MPFL is a growing area of research. The most impactful articles relate to cadaveric/anatomic articles; however, over time, clinical articles became more prevalent

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Quantitative estimates of glacial refugia for chimpanzees (Pan troglodytes) since the Last Interglacial (120,000 BP).

Paleoclimate reconstructions have enhanced our understanding of how past climates have shaped present-day biodiversity. We hypothesize that the geographic extent of Pleistocene forest refugia and suitable habitat fluctuated significantly in time during the late Quaternary for chimpanzees (Pan troglodytes). Using bioclimatic variables representing monthly temperature and precipitation estimates, past human population density data, and an extensive database of georeferenced presence points, we built a model of changing habitat suitability for chimpanzees at fine spatio-temporal scales dating back to the Last Interglacial (120,000 BP). Our models cover a spatial resolution of 0.0467° (approximately 5.19 km2 grid cells) and a temporal resolution of between 1000 and 4000 years. Using our model, we mapped habitat stability over time using three approaches, comparing our modeled stability estimates to existing knowledge of Afrotropical refugia, as well as contemporary patterns of major keystone tropical food resources used by chimpanzees, figs (Moraceae), and palms (Arecacae). Results show habitat stability congruent with known glacial refugia across Africa, suggesting their extents may have been underestimated for chimpanzees, with potentially up to approximately 60,000 km2 of previously unrecognized glacial refugia. The refugia we highlight coincide with higher species richness for figs and palms. Our results provide spatio-temporally explicit insights into the role of refugia across the chimpanzee range, forming the empirical foundation for developing and testing hypotheses about behavioral, ecological, and genetic diversity with additional data. This methodology can be applied to other species and geographic areas when sufficient data are available

Diagnosis and management of Cornelia de Lange syndrome:first international consensus statement

Cornelia de Lange syndrome (CdLS) is an archetypical genetic syndrome that is characterized by intellectual disability, well-defined facial features, upper limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in any one of seven genes, all of which have a structural or regulatory function in the cohesin complex. Although recent advances in next-generation sequencing have improved molecular diagnostics, marked heterogeneity exists in clinical and molecular diagnostic approaches and care practices worldwide. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria, both for classic CdLS and non-classic CdLS phenotypes, molecular investigations, long-term management and care planning

Indian plate structural inheritance in the Himalayan foreland basin, Nepal

The Himalaya, the Earth's largest active orogen, produces a deep but relatively unexplored foreland basin by loading the Indian Plate. Newly available two-dimensional seismic data (ca. 5,180 line km) spanning 900 km of the Nepali lowlands allow mapping and interpretation of several regional subsurface markers in two-way-travel time and estimated depth. Isopach maps for the major intervals allow us to interpret the interplay between basement structure, flexure, and faulting within the Ganga Basin. The Indian continental lithosphere beneath the foreland basin contains basement ridges oriented at high angles to the thrust belt. These basement structural highs and intervening depressions, tens to hundreds of kilometres wide, influenced deposition of the Precambrian Vindhyan strata and overlying Paleozoic to Mesozoic successions. The overlying Miocene to Quaternary foreland basin shows along-strike thickness variations across the basement features. Because the foreland basin sediments were mainly deposited in an alluvial plain close to sea-level, accommodation, and therefore thickness, was predominantly controlled by subsidence of the Indian Plate, providing evidence that the basement features controlled foreland basin development. Subsidence varied in time and space during Neogene basin development. When combined with flexural modelling, these observations imply that the subsidence history of the basin was controlled by inherited lateral variations in the flexural rigidity of the Indian Plate, as it was translated northward beneath the Himalayan Orogen. Basement features continue to play a role in higher levels of the thrust belt, showing that basement features in a down-going plate may produce non-cylindrical structures throughout orogen development