Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry:development of a novel method

Teicoplanin is an antibiotic used for the treatment of endocarditis, osteomyelitis, septic arthritis and methicillin-resistant Staphylococcus aureus. Teicoplanin is emerging as a suitable alternative antibiotic to vancomycin, where their trough serum levels are monitored by immunoassay routinely. This is the first report detailing the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring teicoplanin in patients' serum

Achieving minimum-error discrimination of an arbitrary set of laser-light pulses

Laser light is widely used for communication and sensing applications, so the optimal discrimination of coherent states--the quantum states of light emitted by a laser--has immense practical importance. However, quantum mechanics imposes a fundamental limit on how well different coher- ent states can be distinguished, even with perfect detectors, and limits such discrimination to have a finite minimum probability of error. While conventional optical receivers lead to error rates well above this fundamental limit, Dolinar found an explicit receiver design involving optical feedback and photon counting that can achieve the minimum probability of error for discriminating any two given coherent states. The generalization of this construction to larger sets of coherent states has proven to be challenging, evidencing that there may be a limitation inherent to a linear-optics-based adaptive measurement strategy. In this Letter, we show how to achieve optimal discrimination of any set of coherent states using a resource-efficient quantum computer. Our construction leverages a recent result on discriminating multi-copy quantum hypotheses (arXiv:1201.6625) and properties of coherent states. Furthermore, our construction is reusable, composable, and applicable to designing quantum-limited processing of coherent-state signals to optimize any metric of choice. As illustrative examples, we analyze the performance of discriminating a ternary alphabet, and show how the quantum circuit of a receiver designed to discriminate a binary alphabet can be reused in discriminating multimode hypotheses. Finally, we show our result can be used to achieve the quantum limit on the rate of classical information transmission on a lossy optical channel, which is known to exceed the Shannon rate of all conventional optical receivers.Comment: 9 pages, 2 figures; v2 Minor correction

Evaluating the Chinese Revised Controlling Behaviors Scale (C-CBS-R)

The present study evaluated the utility of the Chinese version of the Revised Controlling Behaviors Scale (C-CBS-R) as a measure of controlling behaviors in violent Chinese intimate relationships. Using a mixed-methods approach, in-depth, individual interviews were conducted with 200 Chinese women survivors to elicit qualitative data about their personal experiences of control in intimate relationships. The use of controlling behaviors was also assessed using the C-CBS-R. Interview accounts suggested that the experiences of 91 of the women were consistent with the description of coercive control according to Dutton and Goodman’s (2005) conceptualization of coercion. Using the split-half validation procedure, a receiver operating characteristics (ROC) curve analysis was conducted with the first half of the sample. The area under the curve (AUC) for using the C-CBS-R to identify high control was .99, and the cutoff score of 1.145 maximized both sensitivity and specificity. Applying the cutoff score to the second half gave a sensitivity of 96% and a specificity of 95%. Overall, the C-CBS-R has demonstrated utility as a measure of controlling behaviors with a cutoff score for distinguishing high from low levels of control in violent Chinese intimate relationships

Theoretical X-Ray Absorption Debye-Waller Factors

An approach is presented for theoretical calculations of the Debye-Waller factors in x-ray absorption spectra. These factors are represented in terms of the cumulant expansion up to third order. They account respectively for the net thermal expansion $\sigma^{(1)}(T)$, the mean-square relative displacements $\sigma^2(T)$, and the asymmetry of the pair distribution function $\sigma^{(3)}(T)$. Similarly, we obtain Debye-Waller factors for x-ray and neutron scattering in terms of the mean-square vibrational amplitudes $u^2(T)$. Our method is based on density functional theory calculations of the dynamical matrix, together with an efficient Lanczos algorithm for projected phonon spectra within the quasi-harmonic approximation. Due to anharmonicity in the interatomic forces, the results are highly sensitive to variations in the equilibrium lattice constants, and hence to the choice of exchange-correlation potential. In order to treat this sensitivity, we introduce two prescriptions: one based on the local density approximation, and a second based on a modified generalized gradient approximation. Illustrative results for the leading cumulants are presented for several materials and compared with experiment and with correlated Einstein and Debye models. We also obtain Born-von Karman parameters and corrections due to perpendicular vibrations.Comment: 11 pages, 8 figure

Electromagnetically induced transparency in superconducting quantum circuits : Effects of decoherence, tunneling and multi-level cross-talk

We explore theoretically electromagnetically-induced transparency (EIT) in a superconducting quantum circuit (SQC). The system is a persistent-current flux qubit biased in a $\Lambda$ configuration. Previously [Phys. Rev. Lett. 93, 087003 (2004)], we showed that an ideally-prepared EIT system provides a sensitive means to probe decoherence. Here, we extend this work by exploring the effects of imperfect dark-state preparation and specific decoherence mechanisms (population loss via tunneling, pure dephasing, and incoherent population exchange). We find an initial, rapid population loss from the $\Lambda$ system for an imperfectly prepared dark state. This is followed by a slower population loss due to both the detuning of the microwave fields from the EIT resonance and the existing decoherence mechanisms. We find analytic expressions for the slow loss rate, with coefficients that depend on the particular decoherence mechanisms, thereby providing a means to probe, identify, and quantify various sources of decoherence with EIT. We go beyond the rotating wave approximation to consider how strong microwave fields can induce additional off-resonant transitions in the SQC, and we show how these effects can be mitigated by compensation of the resulting AC Stark shifts

Formation of shock waves in a Bose-Einstein condensate

We consider propagation of density wave packets in a Bose-Einstein condensate. We show that the shape of initially broad, laser-induced, density perturbation changes in the course of free time evolution so that a shock wave front finally forms. Our results are well beyond predictions of commonly used zero-amplitude approach, so they can be useful in extraction of a speed of sound from experimental data. We discuss a simple experimental setup for shock propagation and point out possible limitations of the mean-field approach for description of shock phenomena in a BEC.Comment: 8 pages & 6 figures, minor changes, more references, to appear in Phys. Rev.

Towards a first principles description of phonons in Ni50_{50}Pt50_{50} disordered alloys: the role of relaxation

Using a combination of density-functional perturbation theory and the itinerant coherent potential approximation, we study the effects of atomic relaxation on the inelastic incoherent neutron scattering cross sections of disordered Ni$_{50}$Pt$_{50}$ alloys. We build on previous work, where empirical force constants were adjusted {\it ad hoc} to agree with experiment. After first relaxing all structural parameters within the local-density approximation for ordered NiPt compounds, density-functional perturbation theory is then used to compute phonon spectra, densities of states, and the force constants. The resulting nearest-neighbor force constants are first compared to those of other ordered structures of different stoichiometry, and then used to generate the inelastic scattering cross sections within the itinerant coherent potential approximation. We find that structural relaxation substantially affects the computed force constants and resulting inelastic cross sections, and that the effect is much more pronounced in random alloys than in ordered alloys.Comment: 8 pages, 3 eps figures, uses revtex

Superconductivity at 2.3 K in the misfit compound (PbSe)1.16(TiSe2)2

The structural misfit compound (PbSe)1.16(TiSe2)2 is reported. It is a superconductor with a Tc of 2.3 K. (PbSe)1.16(TiSe2)2 derives from a parent compound, TiSe2, which shows a charge density wave transition and no superconductivity. The crystal structure, characterized by high resolution electron microscopy and powder x-ray diffraction, consists of two layers of 1T-TiSe2 alternating with a double layer of (100) PbSe. Transport measurements suggest that the superconductivity is induced by charge transfer from the PbSe layers to the TiSe2 layers.Comment: 17 pages, 4 figures. To be published in Physical Review