283 research outputs found
Analysis on existent thermal insulating plasters towards innovative applications: evaluation methodology for a real cost-performance comparison
Thermal insulating plasters are an important means to face the energy efficiency issues in building field, above all in renovation processes. New solutions, such as nanotechnology or aerogel based plasters, could make a significant contribution to this field, reaching higher level of thermal performance and reducing needed thickness. But, in order to be really suitable for the market, new plaster solutions have to answer to specific economical and technical needs.
This research provides an overall analysis of thermal insulating plasters in European market, comparing existing products according to technical specifications and economical features
The main goal of this survey is to drive researches in thermal plasters fields towards innovative application, creating new plasters able to meets real market and end-users demands.
Technical cross assessment considers three main factors, defined according to European standards: volume mass powder, dry bulk density of hardened mortar and thermal conductivity. Benchmarking analysis compares prices per unit, in order to relate material quantity to the achieving of common Rx value. Cross assessments results allow to define thermal, technical and economical requirements that new thermal insulating plasters have to meet to be suitable for European volume market
Transcriptional Stress Induces Chromatin Relocation of the Nucleotide Excision Repair Factor XPG.
Endonuclease XPG participates in nucleotide excision repair (NER), in basal transcription, and in the processing of RNA/DNA hybrids (R-loops): the malfunction of these processes may cause genome instability. Here, we investigate the chromatin association of XPG during basal transcription and after transcriptional stress. The inhibition of RNA polymerase II with 5,6-dichloro-l-β-D-ribofuranosyl benzimidazole (DRB), or actinomycin D (AD), and of topoisomerase I with camptothecin (CPT) resulted in an increase in chromatin-bound XPG, with concomitant relocation by forming nuclear clusters. The cotranscriptional activators p300 and CREB-binding protein (CREBBP), endowed with lysine acetyl transferase (KAT) activity, interact with and acetylate XPG. Depletion of both KATs by RNA interference, or chemical inhibition with C646, significantly reduced XPG acetylation. However, the loss of KAT activity also resulted in increased chromatin association and the relocation of XPG, indicating that these processes were induced by transcriptional stress and not by reduced acetylation. Transcription inhibitors, including C646, triggered the R-loop formation and phosphorylation of histone H2AX (γ-H2AX). Proximity ligation assay (PLA) showed that XPG colocalized with R-loops, indicating the recruitment of the protein to these structures. These results suggest that transcriptional stress-induced XPG relocation may represent recruitment to sites of R-loop processing
Risk factors for peri-operative high-grade complications in patients with prostate cancer treated with robotic radical prostatectomy
Aim of our study was to evaluate the risk factors for high-grade complications (Clavien Classification System ≥3a) in patients treated with with robotic assisted radical prostatectomy (RARP). Between 2012 and 2017, a consecutive series of patients with prostate cancer were treated with robotic radical prostatectomy (RRP). Demographic, clinical and histological characteristics of the patients were recorded. Histological specimens were graded according to the new PGG classification. Complications were classified according to the modified Clavien classification system (CCS). Logistic regression analysis was performed to evaluate the risk of high grade complications (CCS>3a)
Chitin determination on marine seston in a shallow temperate estuary (Argentina)
A quitina Ă© um dos biopolĂmeros mais abundantes no planeta. A quitina foi quantificada em frações do seston, com a finalidade de obter a primeira caracterização deste polĂmero no Estuário de BahĂa Blanca. A amostragem foi realizada durante o inverno e o verĂŁo em dois locais: em um canal de marĂ© nĂŁo impactado (BahĂa del Medio, BM) e em um setor de descarga de esgoto (Canal Vieja, CV). Os maiores valores de quitina foram observados na fração seston ; 500 µM) nĂŁo excederam ~ 1% de quitina total. A maior concentração de quitina no seston < 20 µM sugere que essa fração Ă© um grande reservatĂłrio deste biopolĂmero, contribuindo para a matĂ©ria orgânica para os microorganismos na cadeia alimentar do Estuário de BahĂa Blanca. Este Ă© o primeiro estudo sobre as possĂveis fontes de quitina em ecossistemas marinhos na Argentina.Chitin is one of the most abundant biopolymers in the planet. Chitin was quantified in seston fractions in order to obtain the first characterization of this polymer in the BahĂa Blanca Estuary. Sampling was conducted at two sites: a non- impacted tidal channel -BahĂa del Medio (BM)- and a sewage discharge sector -Canal Vieja (CV)-, during winter and summer. The highest values of chitin were observed in the seston fraction ;500 µm) did not exceed ~1% of total chitin.. The higher concentration of chitin in sesto
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