26 research outputs found
The Supermassive Black Hole at the Galactic Center
The inner few parsecs at the Galactic Center have come under intense scrutiny
in recent years, in part due to the exciting broad-band observations of this
region, but also because of the growing interest from theorists motivated to
study the physics of black hole accretion, magnetized gas dynamics and unusual
star formation. The Galactic Center is now known to contain arguably the most
compelling supermassive black hole candidate, weighing in at a little over 2.6
million suns. Its interaction with the nearby environment, comprised of
clusters of evolved and young stars, a molecular dusty ring, ionized gas
streamers, diffuse hot gas, and a hypernova remnant, is providing a wealth of
accretion phenomenology and high-energy processes for detailed modeling. In
this review, we summarize the latest observational results, and focus on the
physical interpretation of the most intriguing object in this region---the
compact radio source Sgr A*, thought to be the radiative manifestation of the
supermassive black hole.Comment: Annual Review of Astronomy & Astrophysics, Vol. 39 (2001), in press,
48 pages, 20 figures (partially in reduced quality), also available at
http://www.mpifr-bonn.mpg.de/staff/hfalcke/publications.html#gcrevie
Origin of Cosmic Magnetic Fields
We propose that the overlapping shock fronts from young supernova remnants
produce a locally unsteady, but globally steady large scale spiral shock front
in spiral galaxies, where star formation and therefore massive star explosions
correlate geometrically with spiral structure. This global shock front with its
steep gradients in temperature, pressure and associated electric fields will
produce drifts, which in turn give rise to a strong sheet-like electric
current, we propose. This sheet current then produces a large scale magnetic
field, which is regular, and connected to the overall spiral structure. This
rejuvenates the overall magnetic field continuously, and also allows to
understand that there is a regular field at all in disk galaxies. This proposal
connects the existence of magnetic fields to accretion in disks. We not yet
address all the symmetries of the magnetic field here; the picture proposed
here is not complete. X-ray observations may be able to test it already.Comment: 18 pages, no figures; to be published in Proc. Palermo Meeting Sept.
2002, Eds. N. G. Sanchez et al., The Early Universe and the Cosmic Microwave
Background: Theory and Observation
Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-Derived Peptides by HLA-DR on Human Dendritic Cells
Nitration of pollen derived allergens can occur by NO2 and ozone in polluted air and it has already been shown that nitrated major birch (Betula verrucosa) pollen allergen Bet v 1.0101 (Bet v 1) exhibits an increased potency to trigger an immune response. However, the mechanisms by which nitration might contribute to the induction of allergy are still unknown. In this study, we assessed the effect of chemically induced nitration of Bet v 1 on the generation of HLA-DR associated peptides. Human dendritic cells were loaded with unmodified Bet v 1 or nitrated Bet v 1, and the naturally processed HLA-DR associated peptides were subsequently identified by liquid chromatography-mass spectrometry. Nitration of Bet v 1 resulted in enhanced presentation of allergen-derived HLA-DR-associated peptides. Both the copy number of Bet v 1 derived peptides as well as the number of nested clusters was increased. Our study shows that nitration of Bet v 1 alters antigen processing and presentation via HLA-DR, by enhancing both the quality and the quantity of the Bet v 1-specific peptide repertoire. These findings indicate that air pollution can contribute to allergic diseases and might also shed light on the analogous events concerning the nitration of self-proteins