2 research outputs found
Consequences of long-term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model
The consequences of long term consumption of water from Nworie River
(Owerri, Nigeria) on haematological, hepatic, and renal functions using
rat model (Wistar albino strain). Twenty-four rats separated into two
groups of twelve rats each were kept as test and control for sixty-four
days. The test rats were placed on water from Nworie River while those
of the control were placed on Eva water (purified Coca-cola bottled
water). The rats were sacrificed in two sets: first set was on
thirty-second day while the second set was on the sixty-fourth day. Six
rats each from each group were sacrificed at each set. The Results
obtained revealed that Hb, PCV, WBC, L, N, and ESR were significantly
affected (p<0.05) in test rats against the control rats. The
functional parameters of liver adequacy; AST, ALT, and ALP were
significantly (p<0.05) affected in test rats against those of the
control. Also, urea and electrolyte ions (Potassium ion, chloride and
bicarbonate) indicating renal sufficiency were significantly
(p<0.05) affected in test rats against those of the control.
Creatinine, sodium ion, total bilirubin and conjugated bilirubin were
not significantly affected (p>0.05) in test rats when compared to
those of the control. The induced changes in the parameters
investigated in this study have shown that long-term consumption of
water from Nworie River has effect on haematological, hepatic, and
renal function
Consequences of long-term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model
The consequences of long term consumption of water from Nworie River
(Owerri, Nigeria) on haematological, hepatic, and renal functions using
rat model (Wistar albino strain). Twenty-four rats separated into two
groups of twelve rats each were kept as test and control for sixty-four
days. The test rats were placed on water from Nworie River while those
of the control were placed on Eva water (purified Coca-cola bottled
water). The rats were sacrificed in two sets: first set was on
thirty-second day while the second set was on the sixty-fourth day. Six
rats each from each group were sacrificed at each set. The Results
obtained revealed that Hb, PCV, WBC, L, N, and ESR were significantly
affected (p<0.05) in test rats against the control rats. The
functional parameters of liver adequacy; AST, ALT, and ALP were
significantly (p<0.05) affected in test rats against those of the
control. Also, urea and electrolyte ions (Potassium ion, chloride and
bicarbonate) indicating renal sufficiency were significantly
(p<0.05) affected in test rats against those of the control.
Creatinine, sodium ion, total bilirubin and conjugated bilirubin were
not significantly affected (p>0.05) in test rats when compared to
those of the control. The induced changes in the parameters
investigated in this study have shown that long-term consumption of
water from Nworie River has effect on haematological, hepatic, and
renal function