The consequences of long term consumption of water from Nworie River
(Owerri, Nigeria) on haematological, hepatic, and renal functions using
rat model (Wistar albino strain). Twenty-four rats separated into two
groups of twelve rats each were kept as test and control for sixty-four
days. The test rats were placed on water from Nworie River while those
of the control were placed on Eva water (purified Coca-cola bottled
water). The rats were sacrificed in two sets: first set was on
thirty-second day while the second set was on the sixty-fourth day. Six
rats each from each group were sacrificed at each set. The Results
obtained revealed that Hb, PCV, WBC, L, N, and ESR were significantly
affected (p<0.05) in test rats against the control rats. The
functional parameters of liver adequacy; AST, ALT, and ALP were
significantly (p<0.05) affected in test rats against those of the
control. Also, urea and electrolyte ions (Potassium ion, chloride and
bicarbonate) indicating renal sufficiency were significantly
(p<0.05) affected in test rats against those of the control.
Creatinine, sodium ion, total bilirubin and conjugated bilirubin were
not significantly affected (p>0.05) in test rats when compared to
those of the control. The induced changes in the parameters
investigated in this study have shown that long-term consumption of
water from Nworie River has effect on haematological, hepatic, and
renal function