Can Propranolol be used as the first line treatment in infantile hemangioma?

Hemangiomas are the most common tumors of infancy. Most of them require no treatment, but treatment is needed if dramatic aesthetic, and/or functional impairment as visual or airway obstruction or ulceration arises. We reported a 6-month-old infant presented with a 6-week history of a rapidly growing cutaneus hemangioma on the right eyelid and caused visual impairment. The patient was successfully treated with the use of oral propranolol therapy. We suggest that propranolol can be considered as a first line treatment in a patient with infantil hemangioma

THE CHALLENGES FACED BY SCHOOL COUNSELLORS IN THE REPORTING OF CHILD SEXUAL ABUSE

Identifying and reporting sexually abused children is one of the most important responsibilities of school counsellors. In this study, we aimed to determine the challenges of reporting child sexual abuse. We used a questionnaire form that was prepared by reviewing the literature about reporting sexual abuse. Participants were asked to state their level of knowledge of child sexual abuse, whether they had encountered such cases, whether they faced any challenges when notifying to authorities, and the possible solutions to problems encountered during this process. Of the school counsellors contacted, 40.9% of the participants stated that they encountered a claim of child sexual abuse at least once, but the majority of them (47.4%) could not report it to judicial authorities because of various reasons; such as being unsure whether the event was really happening, anticipating reactions towards them or school management, and fearing the school’s loss of reputation in the case of disclosure.  Article visualizations

Evaluation of The Renal Function in The Intrauterine Growth Restricted Rats and The Effect of Maternal Glucocorticoids

The purpose of the study was to determine the effect of maternal glucocorticoids on experimental growth retarded rats and the effect of maternal undernutrition in different gestation periods for function of the kidney. This study had two sections. In the first section, 5 groups were formed. 10g/d diet was given in the 1st, 2nd, and 3rd trimester and throughout the pregnancy period. The control group was fed a normal diet. In the second section, 3 groups formed and all the rats take 10 g/d diet throughout pregnancy period. To determine the effect of endogenous glucocorticoids first group was treated with metyrapone, second group metyrapone+dexamethasone and the placebo injected saline until 14 days of pregnancy. The offsprings body and kidney weights were detected in the 0, 3rd and 20th weeks of age. Renal extraction functions and blood pressures from tail detected in the 20th week of age. Urinary excretion and glomerular filtration rate were low in rats that had dietary restriction in the last trimester. The glomerular filtration rates were found to be low in the group that had diet restriction during the whole pregnancy. Blood pressure values were found to be lower in the group that had diet restriction during their pregnancy compared to the control group. Kidney weights were similar in all groups in the first phase. It was observed that renal excretion functions were preserved in the group receiving metyrapone treatment, but there was no statistically significant difference between the results. Low blood pressures were normalized with metyrapone treatment. The kidney sizes at the 20th week of the rats which receiving metyrapone treatment were found to be smaller than those receiving physiological saline solution. Food restriction destroys renal functions but no effects with high blood pressure in adulthood. Glucocortiod exposure in pregnancy may reduce renal development

The ımpact of handicap severity on oral and periodontal status of patients with mental retardation

Aim: Mental retardation (MR) subjects comprise a considerable amount of the community and are susceptible to oral and periodontal problems due to insufficient oral care. The aim of this cross-sectional study was to determine the oral health and periodontal status of MR patients in Turkey with regard to periodontal indices and Decay missed filling teeth (DMFT) scores and compare findings according to severity of the MR. Materials and methods: One hundred and five MR patients were included to the study and divided into 3 groups according to MR severity diagnoses. Demographic variables like age, gender, disabled sibling, BMI, living an institution and clinical parameters like plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), missing teeth and DMFT scores were recorded from all subjects. Appropriate statistical analyses were used to compare the findings. Results: There were no statistically significant differences between groups according to age, gender, disabled sibling, living status and DMFT scores. Clinical periodontal indices and the number of missing teeth were showed a statistically significant increasing trend with the severity of MR (p < 0.05). Correlation analysis showed significant positive correlations between PI and periodontal disease measures like GI, PD, CAL and BOP and also between PI and DMFT (p < 0.05). Conclusion: The deteriorated teeth condition and deprived periodontal health of MR patients may be most likely caused by the poor oral hygiene and may be worsen with the severity of the MR

Evaluation of the current disease severity scores in paediatric FMF: Is it necessary to develop a new one?

Objectives: Modified adult disease severity scoring systems are being used for childhood FMF. We aim to test the clinical consistency of two common severity scoring systems and to evaluate the correlation of scores with the type of FMF mutations in paediatric FMF patients since certain mutations are prone to severe disease.Methods. Two hundred and fifty-eight children with FMF were cross-sectionally studied. Assessment of the disease severity was performed by using the modified scoring systems of Mor et al. and Pras et al. Genetic analysis was performed using PCR and restriction endonuclease digestion methods for the presence of 15 FMF gene mutations. FMF mutations were grouped into three based on well-known genotypic-phenotypic associations. Correlation between the mutation groups and the severity scoring systems was assessed. The consistency of the severity scoring systems was evaluated.Results. The results of two scoring systems were not statistically consistent with each other (κ = 0.171). This inconsistency persisted even in a more homogeneous subgroup of patients with only homozygote mutations of M694V, M680I and M694I (κ = 0.125). There was no correlation between the mutation groups and either of the scoring systems (P = 0.002, r = 0,196 for scoring systems of Mor et al.; P = 0.009, r = 0.162 for Pras et al.).Conclusions. The inconsistency of the two scoring systems and lack of correlation between the scoring systems and mutation groups raises concerns about the reliability of these scoring systems in children. There is a need to develop a scoring system in children based on a prospective registry. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved

Clinical and demographic characteristics of children with familial mediterranean fever in Central Anatolia

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A validation of diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in Turkish children

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