Dursun, Ismail

Düsünsel, Ruhan

Gökçek, Ikbal

Gündüz, Zübeyde

Poyrazoglu, Hakan M

Yazici, Cevat

English

PubMed

Hakan M Poyrazoglu

Ikbal Gökçek

Cevat Yazici

Ruhan Düsünsel

Zübeyde Gündüz

Ismail Dursun

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Oxidant and antioxidant status in children with
juvenile idiopathic athritis
Hakan M Poyrazoglu, Ikbal Gökçek, Cevat Yazici, Ruhan Düsünsel*, Zübeyde Gündüz, Ismail Dursun
From 18th Pediatric Rheumatology European Society (PReS) Congress
Bruges, Belgium. 14-18 September 2011
Background
Although the pathogenesis of juvenile idiopathic arthritis
is poorly understood, it is thought that a triggered
inflammation by neutrophil activation due to any reason,
released free oxygen radicals and insufficiency of antioxi-
dant system may play role in the chronic course of this
disease.
Aim
In present study, it was aimed to identify the status of
oxidant-antioxidant systems.
Methods
In this study, 45 patients with JIA were included. In
patients with active disease and in remission, erythrocyte
sedimentation rate (ESR), C-reactive protein (CRP),
Advanced Oxidation Protein Products (AOPP), myelo-
peroxidase (MPO), thiol, Total Anti-oxidant capacity
(TAC), Total Oxidant Capacity (TOC) and neopterin
levels were measured.
Results
Mean age of patients was 9.6 years. Female: male ratio
was 1.5 (F/M=27/18). Oligoarticular JIA was diagnosed
in 21 patients, whereas polyarticular JIA and systemic
JIA in 17 and in seven patients, respectively. During
study period, 23 patients had active disease, while 22
patients were in remission. Mean duration of disease
was 2.2 years.
Serum ESR, CRP, TOC, TAC and, MPO levels were
found higher in the patients with active disease than
those in remission (p<0.05). No difference was found in
neopterin, AOPP and thiol levels.
Conclusion
The results of the present study indicate that oxidant-
antioxidant systems are active in JIA patients during
active phase. This activation in favor of oxidants is
interesting. More comprehensive studies are needed to
determine whether this is cause or result.
Published: 14 September 2011
doi:10.1186/1546-0096-9-S1-P296
Cite this article as: Poyrazoglu et al.: Oxidant and antioxidant status in
children with juvenile idiopathic athritis. Pediatric Rheumatology 2011 9
(Suppl 1):P296.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submitErciyes University Medical Faculty, KAYSERI, Turkey
Poyrazoglu et al. Pediatric Rheumatology 2011, 9(Suppl 1):P296
http://www.ped-rheum.com/content/9/S1/P296
© 2011 Poyrazoglu et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.


Oxidant and antioxidant status in children with juvenile idiopathic athritis

Crossref

Pediatric Rheumatology

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3194664

Oxidant and antioxidant status in children with juvenile idiopathic athritis

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Crossref