In Vivo Comparison of the Efficiency of En-Masse Retraction Using Temporary Anchorage Devices With and Without Orthodontic Appliances on the Posterior Teeth

Objective: To compare the effectiveness of en-masse retraction of maxillary anterior teeth using temporary anchorage devices with and without orthodontic appliances on the posterior teeth.Methods:In the study, 20 participants (18.25 ± 4.07 years) meeting the inclusion criteria were randomly divided into 2 groups using the sequentially numbered opaque sealed envelopes method. In group I (control group, n = 10), en-masse retraction was carried out with conventional high hooks soldered to the retraction wire and posterior teeth were included. In group II (experimental group, n = 10), the en-masse retraction was carried out without an orthodontic appliance on posterior teeth and a modified retraction wire was incorporated. In both groups, mini-implants were placed bilaterally between the maxillary second premolar and maxillary first molar, and a retraction force of 6 ounces (180 g) was applied using power chains. Lateral cephalograms and study models were taken before retraction and 4 months after retraction. All statistical analyses were performed with Statistical Package for the Social Sciences software with a statistically significant level of 5%. We used unpaired t-tests for the comparison, and the error of the method was assessed using intraclass correlation coefficients and the Bland–Altman method.Results: The maxillary incisor apex retraction, change in maxillary incisor in the vertical plane, and its inclination showed statistically significant differences (P < .05). The rate of retraction was significantly greater in the experimental group when evaluated clinically and in the study models (P < .05).Conclusion: The rate/amount of retraction evaluated clinically and in the study models was significantly faster/greater when the posterior teeth were not included during anterior retraction. Also, a greater amount of bodily retraction of anterior teeth was achieved

<span style="font-size:15.0pt;mso-bidi-font-size:12.0pt" lang="EN-GB">Hypolipidemic and antioxidant activity of ethanolic extract of <i style="mso-bidi-font-style:normal">Symplocos racemosa </i>Roxb. in hyperlipidemic rats: An evidence of participation of oxidative stress in hyperlipidemia </span>

36-45Hypolipidemic and antioxidant activity profiles of ethanolic extracts of Symplocos racemosa (EESR) were studied by triton-WR1339 (acute) and high fat diet induced (chronic) hyperlipidemic rat models. In both the models, a significant increase in total cholesterol (TC), triglycerides (TG), very low density lipoproteins (VLDL), low density lipoproteins (LDL) and decrease in high density lipoproteins (HDL) in serum were observed. EESR (200 and 400 mg/kg) and simvastatin (10 mg/kg) administered orally reduced the elevated serum lipids (TC, TG, VLDL, LDL), restored the decreased HDL and improved the atherogenic index. In high fat diet induced hyperlipidemic model, EESR treatment prevented the increased formation of malondialdehyde (MDA) in liver, restored the depleted liver antioxidants, glutathione, superoxide dismutase, catalase significantly. The increased liver cholesterol, HMG-CoA reductase activity and body weight of hyperlipidemic rats were significantly reduced by EESR treatment. The EESR inhibited HMG-CoA reductase, a rate limiting enzyme in cholesterol biosynthesis, thereby causing hypolipidemic effects.<b style="mso-bidi-font-weight: normal"> EESR treatment also improved histoarchitecture of hepatocytes in hyperlipidemic rats. Experimental findings demonstrated anti-hyperlipidemic and antioxidant activity of EESR, which may be directly or indirectly related to its antioxidant activity. The hypolipidemic activity of EESR may be due to the presence of flavonoids phenolic compounds, phenolic glycosides and steroids. </span

Acute myeloid leukemia: a case report with palatal and lingual gingival alterations

yeloblastic leukemia (AML) is a malignant bone marrow disease. Due to its high morbidity rate, early diagnosis and appropriate medical therapy are essential. Dentists and physicians should be aware of the importance of recognizing oral manifestations of this systemic disease. Here we report a case of gingival alterations AML. The interesting clinical findings about this case are the severe alterations of palatal and lingual gingiva with almost normal labial gingiva. The need for early diagnosis and referral of this fatal disease are also underlined