5 research outputs found

    The University’s Roles in the Historical, Social and Cultural Context, and its Importance in the Realization of Human Rights and Brazilian Democracy

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    This research exposes narratives and arguments of conceptual and historical content about the conditions and purposes of the University, particularly in Brazil, seeking to describe and reflect on central aspects of this institution. It is recognized, in advance, the importance of constitutional autonomy and secularism within these institutions. This recognition is understood as fundamental in the process of actualizing human rights in public spaces for the construction of citizenship. The problem of this text is related to the question about how much the libertarian role of the University is supported in reality in the processes of construction of republican democracy. The hypothesis is that at some point the University stopped resisting prejudices, the banality of lies and the habit of bad manners in internal relations between workers and in the institution’s relationship with the community. The University, in our time, has been pressured not to bend to obscurantism, surrendering to market demands and renouncing the exercise of a critical judgment. Thus understood, the University loses consciousness of itself as an autonomous space for freedom of thought and for the development of sciences, arts and morals. Notably, when one observes the return or perpetuity of characteristic traits of neofascist movements and policies, which insist on intending the young Brazilian democracy, the urgency and challenge of rebuilding the University as a privileged locus for basic research, for the construction of advanced knowledge and for the technical application of knowledge before concrete demands is expanded. The task of students is arduous in times of authoritarianism of every order concealed by the progress idea. To carry out this research, the inductive method was used, with dialectical and historical methodological contributions, focusing on the technique of bibliographic research

    Direito penal e complexidade na sociedade pós-moderna

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    Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System

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    We followed the presence of Zika virus (ZIKV) in four healthy adults (two men and two women), for periods ranging from 78 to 298 days post symptom onset. The patients were evaluated regarding the presence of the virus in different body fluids (blood, saliva, urine and semen), development of immune responses (including antibodies, cytokines and chemokines), and virus genetic variation within samples collected from semen and urine during the infection course. The analysis was focused primarily on the two male patients who shed the virus for up to 158 days after the initial symptoms. ZIKV particles were detected in the spermatozoa cytoplasm and flagella, in immature sperm cells and could also be isolated from semen in cell culture, confirming that the virus is able to preserve integrity and infectivity during replication in the male reproductive system (MRS). Despite the damage caused by ZIKV infection within the MRS, our data showed that ZIKV infection did not result in infertility at least in one of the male patients. This patient was able to conceive a child after the infection. We also detected alterations in the male genital cytokine milieu, which could play an important role in the replication and transmission of the virus which could considerably increase the risk of ZIKV sexual spread. In addition, full genome ZIKV sequences were obtained from several samples (mainly semen), which allowed us to monitor the evolution of the virus within a patient during the infection course. We observed genetic changes over time in consensus sequences and lower frequency intra-host single nucleotide variants (iSNV), that suggested independent compartmentalization of ZIKV populations in the reproductive and urinary systems. Altogether, the present observations confirm the risks associated with the long-term replication and shedding of ZIKV in the MRS and help to elucidate patterns of intra-host genetic evolution during long term replication of the virus
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