3 research outputs found
Two Generations of CubeSat Missions (CSSWE and CIRBE) to Take on the Challenges of Measuring Relativistic Electrons in the Earth’s Magnetosphere
The Colorado Student Space Weather Experiment (CSSWE) CubeSat, carrying the Relativistic Electron and Proton Telescope integrated little experiment (REPTile) to measure 0.5 to \u3e3.8 MeV electrons and 8-40 MeV protons, operated for over two years, 2012-2014, in low Earth orbit (LEO). There have been 25 peer-reviewed publications, including two in Nature, and five Ph.D. dissertations associated with CSSWE. Another 3U CubeSat mission: Colorado Inner Radiation Belt Electron Experiment (CIRBE), has been under development to address an unresolved science question: Where is the break point in terms of electron energy below which electrons can be transported into the inner belt from the outer belt but above which they cannot? This requires clean measurements of energetic electrons with fine energy resolution in an environment where all instruments are subject to the unforgiving penetration from highly energetic protons (tens of MeV to GeV). An advanced version of REPTile has been designed and built, REPTile-2. It has been integrated into the CIRBE bus, which has active attitude control, deployable solar panels, and a S-band radio, provided by Blue Canyon Technologies. CIRBE advances our science capabilities and has significantly improved performance vs. CSSWE and is ready to be launched into a LEO in early 2023
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The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study
Abstract: Purpose: Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO. Methods: Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly. Results: Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p < 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02). Conclusions: Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21
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The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study
Abstract: Purpose: Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO. Methods: Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly. Results: Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p < 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02). Conclusions: Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21