Lectura de contexto y abordaje psicosocial desde los enfoques narrativos. Ibagué

Teniendo en cuenta los ejes temáticos del diplomado utilizados: Acompañamiento Psicosocial a las víctimas del conflicto armado, Proceso de Afrontamiento del Trauma Emocional y Duelo, Rehabilitación y atención terapéutica, Construcción de subjetividades en el sujeto, Reconstrucción de historia a través de la memoria, Subjetividad colectiva y violencia. Y a través del enfoque narrativo se busca construir un camino de trasformación para que a través de la narración de historias las víctimas vuelvan a soñar, a tener esperanza y nuevos propósitos. En este documento encontrarán el análisis del relato Ana Ligia, seguido de una serie de preguntas clasificadas en: preguntas estratégicas, circulares y reflexivas que se plantean para realizar un proceso investigativo de parte del Psicólogo Social Comunitario que permita a éste tener conocimiento del estado de la persona que ha sido vulnerada en derechos humanos. Luego se plantean tres estrategias psicosociales, para el abordaje del caso Pandurí que ayuden con el mejoramiento de la calidad de vida de las víctimas. Finalmente se dan las respectivas conclusiones y las referencias bibliográficas que se utilizaron como apoyo.Taking into account the thematic axes of the diploma used: Psychosocial accompaniment to the victims of the armed conflict, Process of Coping with Emotional Trauma and Grief, Rehabilitation and therapeutic care, Construction of subjectivities in the subject, Reconstruction of history through memory, Subjectivity collective and violence. And through the narrative approach seeks to build a path of transformation so that through the storytelling, the victims can dream again, hope and new purposes. In this document you will find the analysis of the Ana Ligia Story, followed by a series of questions classified into: strategic, circular and reflective questions that are posed to carry out a research process on behalf of the Community Social Psychologist that allows him to have knowledge of the state of the person who has been violated in human rights. Then, three psychosocial strategies are proposed for the Pandurí case management that help with the improvement of the quality of life of the victims. Finally, the respective conclusions and bibliographical references that were used as support are given

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality