Mean values in RLS severity (IRLS), quality of life (SF-36), depression (CES-D) and sleep (PSQI) scales at baseline 12-months, 24-months and 36-months follow-up.

a<p>p-value for difference between assessments according to one-way repeated measures ANOVA.</p

Mean IRLS^a score according to six age groups at baseline, 6-, 12- 24- and 36-months follow-up.

<p>Mean IRLS^a score according to six age groups at baseline, 6-, 12- 24- and 36-months follow-up.</p

Clinical characteristics and differences in health status according to changes in RLS severity (IRLS^c) over 36 months.

<p>*p for differences between the 3 groups derived from one-way analysis of variance (ANOVA) unless otherwise noted.</p>a<p>Chi-square test for the difference between gender.</p>b<p>Change in the International Restless Legs Study Group (IRLSSG) Rating Scale for severity of RLS between baseline and 36 months follow-up: worsening = increase in score by >5 points, unchanged = change in score not more than ±5 points, improving =  decrease in score >5 points.</p>c<p>International Restless Legs Study Group Rating Scale for severity of RLS (IRLS).</p

Characteristics of the COR-Study participants at baseline.

a<p>based on self-reported weight and height.</p>b<p>self-reported physician diagnosis.</p

Figure 2

<p>A) Short term variation of the RLS minimal criterion “urge to move” in the 7-day diary, according to IRLS^a score and time of the day. B) Short term variation of the RLS minimal criterion “dysaesthesia” in the 7-day diary according IRLS^a score and time of the day.</p